To avoid “ultimate harm,” or human extinction, Ingmar Persson and Julian Savulescu maintain that a species-wide, biological upgrade of human morality is required. To support their claim that we already possess biological kernels of their featured, prosocial attitudes, they rely implausibly on evolutionary psychology. Further, they support “neuroessentialism” and misconceive what genetic manipulation could deliver regarding complex phenotypic traits. Alongside their talk of augmenting prosocial attitudes, Persson and Savulescu stress that, to forestall ultimate harm, what we ultimately require is the elimination of antisocial acts. Though presented as two interpretive lenses on one endeavor, their prosocial and antisocial focuses represent different agendas for our moral alteration. Further, from their utilitarian standpoint, if making antisocial acts impossible to perform were a streamlined route to avoiding extinction, then this is what we should do. Persson and Savulescu’s antisocial focus, in particular, reflects a willingness to forgo what makes human existence worth conducting.