Knowledge representation and management techniques can be efficiently used to improve data modeling and IR functionalities of P2P Information Systems, which have recently attracted a lot of attention from both industrial and academic research communities. These functionalities can be achieved by pushing semantics in both data and queries, and exploiting the derived expressiveness to improve file sharing primitives and lookup mechanisms made available by first-generation P2P systems. XML-based P2P Information Systems are a more specific instance of this class of systems, where the overall data domain is composed by very large, Internet-like distributed XML repositories from which users extract useful knowledge by means of IR methods implemented on top of XML join queries against the repositories. In this chapter, we first focus our attention on the definition and the formalization of the XML-based P2P Information Systems class, also deriving interesting properties on such systems, and then we present a knowledge-representation-and-management-based framework, enriched via semantics, that allows us to efficiently process knowledge and support advanced IR techniques in XML-based P2P Information Systems, thus achieving the definition of the so-called Semantically-Augmented XML-based P2P Information Systems. Also, we complete our analytical contribution with an experimental evaluation of our framework against state-of-the-art IR techniques for P2P networks, and its theoretical analysis in comparison with other similar semantics-based proposals.