This chapter discusses sustainability in supply chains. It starts with a review of the concepts of sustainability and supply chain management; provides a discussion on the globalization of supply chains, its influence on sustainability, benefits of sustainable supply chains followed by the factors affecting the sustainability of supply chains, challenges in integrating sustainability into supply chains and managerial implications. It discusses the influence of supply chains on the triple bottom line. Examples of major factors affecting environmental and social sustainability include travel distances, modes of transportation, vessels used, frequency of trips, packaging materials, efficiencies of manufacturing processes, efficiencies in power generation/distribution, treatments given to polluted air/water generated during various processing from industries, expected product lifetime, manufactured quality of items, management of items failed during warranty or transportation, and the management of disposal of items, among others. The chapter concludes with a future research agenda.