Partial reversal of canities in a 22-year-old normal Chinese male

1993 ◽  
Vol 129 (6) ◽  
pp. 789-791 ◽  
Author(s):  
D. J. Tobin
Keyword(s):  
Chinese Male ◽  
Partial Reversal

scholarly journals Autophagic degradation of the BCR-ABL oncoprotein and generation of antileukemic responses by arsenic trioxide

Blood ◽  
2012 ◽  
Vol 120 (17) ◽  
pp. 3555-3562 ◽  
Author(s):  
Dennis J. Goussetis ◽  
Elias Gounaris ◽  
Edward J. Wu ◽  
Eliza Vakana ◽  
Bhumika Sharma ◽  
...  
Keyword(s):  
Arsenic Trioxide ◽  
Chronic Myelogenous Leukemia ◽  
Cathepsin B ◽  
Myelogenous Leukemia ◽  
Molecular Targeting ◽  
Therapeutic Approaches ◽  
Subsequent Degradation ◽  
Autophagic Degradation ◽  
Partial Reversal

Abstract We provide evidence that arsenic trioxide (As2O3) targets the BCR-ABL oncoprotein via a novel mechanism involving p62/SQSTM1-mediated localization of the oncoprotein to the autolysosomes and subsequent degradation mediated by the protease cathepsin B. Our studies demonstrate that inhibitors of autophagy or cathepsin B activity and/or molecular targeting of p62/SQSTM1, Atg7, or cathepsin B result in partial reversal of the suppressive effects of AS2O3 on BCR-ABL expressing leukemic progenitors, including primitive leukemic precursors from chronic myelogenous leukemia (CML) patients. Altogether, these findings indicate that autophagic degradation of BCR-ABL is critical for the induction of the antileukemic effects of As2O3 and raise the potential for future therapeutic approaches to target BCR-ABL expressing cells by modulating elements of the autophagic machinery to promote BCR-ABL degradation.

Pyruvate kinase from the liver and kidney of Arapaima gigas

1978 ◽  
Vol 56 (4) ◽  
pp. 852-859 ◽  
Author(s):  
H. Guderley ◽  
J. H. A. Fields ◽  
J. M. Cardenas ◽  
P. W. Hochachka
Keyword(s):  
Pyruvate Kinase ◽  
Arapaima Gigas ◽  
Liver And Kidney ◽  
Low Levels ◽  
Pyruvate Kinases ◽  
Regulatory Properties ◽  
Partial Reversal

Pyruvate kinases from the kidney and liver of the osteoglossid Arapaima gigas were partially purified and characterized kinetically. The two enzymes have different elect rophoretic mobilities at pH 7.0, and while they share some qualitative similarities they show quantitative differences in their catalytic and regulatory properties. Both enzymes are activated by fructose 1.6-bisphosphate and inhibited by low levels of alanine and MgATP. The liver isozyme shows hyperbolic phosphoenolpyruvate binding, with a K1 for alanine inhibition of 0.7 mM and a K1 for MgATP inhibition of 1.0 mM. In contrast, the kidney isozyme shows cooperative phosphoenolpyruvate binding, which is accentuated at low levels of ADP. MgATP inhibition does not increase the cooperativity and shows an apparent K1 of 1.68 mM. The inhibition of alanine leads to considerable increases in the cooperativity and is effective at 1 mM and lower levels. Fructose 1.6-bisphosphate completely reverses the inhibition by alanine for both isozymes, while only leading to a partial reversal of the MgATP inhibition. These regulatory properties of both the kidney and the liver isozymes suit them for function in tissues which undergo both glycolysis and gluconeogenesis.

Determinants of salivary cotinine concentrations in Chinese male smokers

2003 ◽  
Vol 36 (3) ◽  
pp. 282-290 ◽  
Author(s):  
Maritta S Jaakkola ◽  
Jiemin Ma ◽  
Gonghuan Yang ◽  
Ming-Feng Chin ◽  
Neal L Benowitz ◽  
...  
Keyword(s):  
Salivary Cotinine ◽  
Chinese Male
Sign in / Sign up

Export Citation Format

Share Document