Promising Results From a Preliminary Study of Autologous Platelet Gel in Face-lift Surgery

Purpose: The aim of the present study is to evaluate the influence and efficacy of autologous platelets on bone regeneration in a rabbit defects model. Materials and Methods: A total of 12 critical size tibial defects were produced in six New Zealand rabbits: A total of six defects were filled with autologous platelet gel (APG) and six defects were maintained as untreated controls. No membranes were used to cover the bone osteotomies. The histology and histomorphometry were performed at four weeks on retrieved samples of both groups. Results: No complications were reported in any of the animals nor for the defects produced. A significantly higher lamellar and woven bone percentage was reported for the APG group with a lower level of marrow spaces (p < 0.05). Evidence of newly formed bone was found in the superficial portion of the bone defect of APG samples where no aspects of bone resorption were observed. Conclusions: The evidence of the present research revealed that APG increases new bone formation restricted to the cortical portion and induces more rapid healing in rabbit bone defects than in untreated defects.

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Completely Autologous Platelet Gel in Breast Reduction Surgery: A Blinded, Randomized, Controlled Trial

Plastic & Reconstructive Surgery ◽

10.1097/01.prs.0000254344.36092.47 ◽

2007 ◽

Vol 119 (4) ◽

pp. 1159-1166 ◽

Cited By ~ 7

Author(s):

Alexander Anzarut ◽

Craig R. Guenther ◽

David C. Edwards ◽

Ross T. Tsuyuki

Keyword(s):

Randomized Controlled Trial ◽

Breast Reduction ◽

Controlled Trial ◽

Platelet Gel ◽

Breast Reduction Surgery ◽

Randomized Controlled ◽

Autologous Platelet

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A report on the use of a single intra-articular administration of autologous platelet therapy in a naturally occurring canine osteoarthritis model - a preliminary study

BMC Musculoskeletal Disorders ◽

10.1186/s12891-020-3140-9 ◽

2020 ◽

Vol 21 (1) ◽

Cited By ~ 2

Author(s):

J. C. Alves ◽

A. Santos ◽

P. Jorge ◽

C. Lavrador ◽

L. Miguel Carreira

Keyword(s):

Naturally Occurring ◽

Preliminary Study ◽

Autologous Platelet ◽

Canine Osteoarthritis

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Resynthesis of sternal dehiscence with autologous bone graft and autologous platelet gel

Journal of Wound Care ◽

10.12968/jowc.2012.21.2.74 ◽

2012 ◽

Vol 21 (2) ◽

pp. 74-77 ◽

Cited By ~ 2

Author(s):

M. Lusini ◽

A. Di Martino ◽

C. Spadaccio ◽

A. Rainer ◽

M. Chello ◽

...

Keyword(s):

Bone Graft ◽

Autologous Bone Graft ◽

Platelet Gel ◽

Sternal Dehiscence ◽

Autologous Bone ◽

Autologous Platelet

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A controlled study of the use of autologous platelet gel for the treatment of diabetic foot ulcers

Nutrition Metabolism and Cardiovascular Diseases ◽

10.1016/s0939-4753(04)80029-2 ◽

2004 ◽

Vol 14 (6) ◽

pp. 395-396 ◽

Cited By ~ 35

Author(s):

G. Saldalamacchia ◽

E. Lapice ◽

V. Cuomo ◽

E. De Feo ◽

E. D'Agostino ◽

...

Keyword(s):

Diabetic Foot ◽

Controlled Study ◽

Foot Ulcers ◽

Diabetic Foot Ulcers ◽

Platelet Gel ◽

Autologous Platelet

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Histologic Effects of Autologous Platelet Gel in Skin Flap Healing

Archives of Facial Plastic Surgery ◽

10.1001/archfaci.9.4.260 ◽

2007 ◽

Vol 9 (4) ◽

pp. 260-263 ◽

Cited By ~ 15

Author(s):

Rakesh K. Chandra ◽

Charles Handorf ◽

Mitch West ◽

Emma A. Kruger ◽

Scott Jackson

Keyword(s):

Skin Flap ◽

Platelet Gel ◽

Autologous Platelet

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Autologous Platelet Gel (APG): A Preliminary Evaluation of the Mechanical Properties after Activation with Autologous Thrombin and Calcium Chloride

Materials ◽

10.3390/ma14143941 ◽

2021 ◽

Vol 14 (14) ◽

pp. 3941

Author(s):

Antonio Scarano ◽

Calogero Bugea ◽

Lucia Leo ◽

Pablo Santos de Oliveira ◽

Felice Lorusso

Keyword(s):

Mechanical Properties ◽

Tensile Strength ◽

Calcium Chloride ◽

Preliminary Evaluation ◽

Loading Test ◽

Platelet Gel ◽

Group I ◽

Group Ii ◽

Autologous Platelet

The tensional and mechanical behavior of regenerative components, grafts, and blood clots represent an essential condition for the success of bone regeneration protocols. Autologous platelet growth factors represent a useful protocol to enhance the soft and hard tissue healing in several fields of medicine and craniofacial surgery. Different protocols for blood concentrates with and without activation have been proposed in literature. The aim of the present study was to investigate in vitro the mechanical properties of autologous platelet gel (APG) with autologous thrombin and calcium chloride. Materials and Methods: A total of 20 APG samples were evaluated; 10 samples were activated by autologous thrombin and calcium chloride (Group I) and 10 samples were non-activated (Group II). The tensile strength and modulus of elasticity were calculated through a static loading test (Lloyd 30 K, Lloyd Instruments Ltd., Segensworth, UK). Results: Group I (activated) reported a tensile strength of 373.5 ± 14.3 MPa, while Group II showed a significantly lower value of of 360.5 ± 16.3 MPa (p < 0.05). The Young’s modulus was 145.3 ± 10.4 MPa for Group I and 140.3 ± 15.3 MPa for Group II (p < 0.05). Conclusions: The effectiveness of the present in vitro simulation showed that the APG activation protocol is able to increase the mechanical characteristics of the blood derivates and could be clinically useful to enhance regenerative procedures.

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