scholarly journals Role of Autologous Platelet Gel (APG) in Bone Healing: A Rabbit Study

2021 ◽  
Vol 11 (1) ◽  
pp. 395
Author(s):  
Antonio Scarano ◽  
Francesco Inchingolo ◽  
Biagio Rapone ◽  
Alberta Greco Lucchina ◽  
Erda Qorri ◽  
...  
Keyword(s):  
Critical Size ◽  
Bone Defects ◽  
New Bone Formation ◽  
Platelet Gel ◽  
Woven Bone ◽  
Rapid Healing ◽  
Rabbit Bone ◽  
Autologous Platelet ◽  
New Zealand Rabbits

Purpose: The aim of the present study is to evaluate the influence and efficacy of autologous platelets on bone regeneration in a rabbit defects model. Materials and Methods: A total of 12 critical size tibial defects were produced in six New Zealand rabbits: A total of six defects were filled with autologous platelet gel (APG) and six defects were maintained as untreated controls. No membranes were used to cover the bone osteotomies. The histology and histomorphometry were performed at four weeks on retrieved samples of both groups. Results: No complications were reported in any of the animals nor for the defects produced. A significantly higher lamellar and woven bone percentage was reported for the APG group with a lower level of marrow spaces (p < 0.05). Evidence of newly formed bone was found in the superficial portion of the bone defect of APG samples where no aspects of bone resorption were observed. Conclusions: The evidence of the present research revealed that APG increases new bone formation restricted to the cortical portion and induces more rapid healing in rabbit bone defects than in untreated defects.

scholarly journals Artificial extracellular matrix - a promising approach to enhance new bone formation in critical size bone defects

2016 ◽  
Vol 4 ◽  
Author(s):  
F�rster Yvonne ◽  
Hintze Vera ◽  
M�ller Stefanie ◽  
Schnabelrauch Matthias ◽  
Scharnweber Dieter ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Bone Formation ◽  
Critical Size ◽  
Bone Defects ◽  
New Bone Formation ◽  
Artificial Extracellular Matrix

Topical Simvastatin Improves the Pro-Angiogenic and Pro-Osteogenic Properties of Bioglass Putty in the Rat Calvaria Critical-Size Model

2014 ◽  
Vol 40 (3) ◽  
pp. 251-258 ◽  
Author(s):  
Irit Allon ◽  
Yakir Anavi ◽  
Dror M. Allon
Keyword(s):  
Bioactive Glass ◽  
Wistar Rats ◽  
Volume Fraction ◽  
Critical Size ◽  
New Bone Formation ◽  
Calvarial Bone ◽  
Critical Size Defects ◽  
Woven Bone ◽  
Rat Calvaria ◽  
Male Wistar Rats

Objective was to describe the effect of bioactive glass putty with and without topical simvastatin on new bone formation in critical-sized defects of rat calvaria. A calvarial bone defect was created in 20 male Wistar rats and filled with bioactive glass alone (n = 10) or combined with simvastatin (n = 10). After 4 weeks, the defects were histomorphometrically evaluated for volume fraction (Vv) of woven bone, vessel density, bioglass quantity, and inflammation. Compared to the bioglass-only group, rats treated with simvastatin had greater Vv of blood vessels (3.3% ± 0.7 vs 1.6% ± 0.1, P = .0002) and new bone (2.3% ± 0.2 vs 1.8% ± 2.5, P = .003). The Vv of the bioglass remnants in the bioglass-only group was higher than in the group treated with simvastatin (2.4% ± 0.08 vs 1.7% ± 0.3, P &lt; .0004). Chronic inflammation was noted in 1 rat from each group. Topical simvastatin seems to improve the pro-angiogenic and pro-osteogenic properties of bioglass putty in rat calvaria critical-size defects without significant inflammation.

scholarly journals Evaluation of Amniotic-Derived Membrane Biomaterial as an Adjunct for Repair of Critical Sized Bone Defects

2014 ◽  
Vol 2014 ◽  
pp. 1-4 ◽  
Author(s):  
Mikael Starecki ◽  
John A. Schwartz ◽  
Daniel A. Grande
Keyword(s):  
Bone Formation ◽  
Bone Graft ◽  
Critical Size ◽  
Bone Defects ◽  
Autogenous Bone Graft ◽  
Autogenous Bone ◽  
New Bone Formation ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

Introduction. Autogenous bone graft is the gold standard in reconstruction of bone defects. The use of autogenous bone graft is problematic because of limited bone as well as donor site morbidity. This study evaluates a novel biomaterial as an alternative to autogenous bone graft. The biomaterial is amniotic membrane, rich in growth factors. Methods. Twenty-one adult male Sprague-Dawley rats were implanted with biomaterial using the rat critical size femoral gap model. After creation of the critical size femoral gap animals were randomized to one of the following groups: Group 1 (control): gap left empty and received no treatment; Group 2 (experimental): the gap was filled with commercially available bone graft; Group 3 (experimental): the gap was filled with bone graft plus NuCel amniotic tissue preparation. Results. The experimental groups demonstrated new bone formation compared to controls. The results were evident on radiographs and histology. Histology showed Group 1 controls to have 11.1% new bone formation, 37.8% for Group 2, and 49.2% for Group 3. These results were statistically significant. Conclusions. The study demonstrates that amniotic membrane products have potential to provide bridging of bone defects. Filling bone defects without harvesting autogenous bone would provide a significant improvement in patient care.

Evaluation of the role of platelet gel in promoting healing of phalangeal fractures after fixation by Kirschner wires

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Asmaa A Al Sabbagh ◽  
Ashraf M Farid ◽  
Mohamed A El Rouby ◽  
Sarah A Abdalmaksoud
Keyword(s):  
Recovery Time ◽  
Kirschner Wires ◽  
Interventional Study ◽  
Platelet Gel ◽  
Early Improvement ◽  
X Ray ◽  
High Concentrations ◽  
Phalangeal Fractures ◽  
Autologous Platelet

Abstract Background Autologous Platelet gel may become an ideal autologously prepared biologic blood-derived product that can be exogenously applied to a diversity of tissues, in which it releases high concentrations of platelet growth factors that enhance healing. Aim of the Work to evaluate the role of platelet gel in promoting healing in phalangeal fractures. Patients and Methods This study was conducted on 20 Patients were operated either by general or local anesthesia in a prospective interventional study for: evaluation the role of platelet gel in promoting healing of phalangeal fractures after fixation by Kirschner wires. Results In this study: clinical and radiographic signs of healing at 12wks were achieved in 70% of studied patients and 16wks were achieved in 30% of studied patients and early improvement of swelling and tenderness. Conclusion The use of Autologous platelet gel in phalangeal fractures after fixation by Kirschner wires gives a significant improvement quickly over the periods according to swelling, tenderness and x-ray healing So decrease recovery time and return to work and activities.

Public and Private Net Savings in Developing Countries: Some Empirical Tests for the Period 1972-88 (Distinguishedl Lecture)

1992 ◽  
Vol 31 (4I) ◽  
pp. 431-447
Author(s):  
Peter A. Cornelisse ◽  
Elma Van De Mortel
Keyword(s):  
Public Debt ◽  
World Economy ◽  
Socioeconomic Development ◽  
Critical Size ◽  
Public And Private ◽  
Critical Dimensions ◽  
The Public ◽  
Empirical Tests ◽  
Financial Issues

The severe shocks that rocked the world economy in the 1970s and the ensuing efforts to adjust and to renew economic growth have had a profound effect on the economic literature. Especially the external and public debt problems which reached critical dimensions in many countries attracted much attention. Thus, in the field of macroeconomics financial issues have gained more prominence over the last two decades. Studies relating to the fiscal deficit have been particularly numerous. The critical size of national public debts, the contribution of the public debt to external debt, the reduced confidence in the state as the guide in socioeconomic development and the role of fiscal policy in adjustment processes are among the main reasons for this increased interest.

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