The nonutility of chest roentgenographic examination in asymptomatic patients with positive tuberculin test results

OBJECTIVES: The study aimed to determine the frequency of COVID-19 positive antenatal patients admitted in Obstetrics & Gynecology unit Hayatabad Medical Complex Peshawar with the concerns that pregnant women may be more susceptible to COVID-19 as they may be more vulnerable to respiratory infection. METHODOLOGY: This was a descriptive cross-sectional study conducted at Obstetrics & Gynecology units Hayatabad Medical Complex Peshawar from May 12th, 2020, to November 29th, 2020, screening and testing of patients admitted for childbirth was in HMC. Screening consisted of questions related to travel, contacts, and symptoms of COVID-19. All patients without a prior diagnosis of COVID-19 underwent SARS-CoV-2 polymerase chain reaction (PCR) testing of nasopharyngeal swabs, with rapid testing available. Patients scheduled for cesarean birth were screened and tested at preoperative visits RESULTS: One hundred eighty-two patients presenting for antenatal visits were screened; 6.5% (12 out of 182) were previously diagnosed with COVID-19. The remaining 170 patients were tested at admission, and 17.6% (30 out of 170) tested positive for SARS-CoV-2. Twenty-two of the 30 who tested positive for SARS-CoV-2 (73.3%) were asymptomatic. The overall prevalence of positive test results among asymptomatic patients was 14.1% (22 out of 156). The prevalence of positive test results among asymptomatic patients increased from 1.29% (2 out of 155). CONCLUSION: The evidence on this novel infection is changing almost daily, although it will likely be many months before, we can determine the true impact it will have on both maternal and fetal well‐being. In the interim, our primary responsibility is to ensure all women have access to safe maternity services. KEYWORDS: Asymptomatic, COVID-19 Positive, Antenatal Patients, Obstetrics & Gynecology, Infection

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A1254 HOW FREQUENTLY DO ASYMPTOMATIC PATIENTS BENEFIT FROM THE PURSUIT OF ABNORMALITIES IN THEIR PREOPERATIVE TEST RESULTS?

Anesthesiology ◽

10.1097/00000542-199009001-01254 ◽

1990 ◽

Vol 73 (3A) ◽

pp. NA-NA ◽

Cited By ~ 2

Author(s):

J. Apfelbaum ◽

M. F. Roizen ◽

D. Robinson ◽

W. J. Murray ◽

A. W. Grogono ◽

...

Keyword(s):

Test Results ◽

Asymptomatic Patients ◽

Preoperative Test

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Frequency of tuberculin testing

PEDIATRICS ◽

10.1542/peds.56.2.160a ◽

1975 ◽

Vol 56 (2) ◽

pp. 160-161

Author(s):

Alex J. Steigman ◽

Edwin L. Kendig

Keyword(s):

American Academy ◽

Personal Experience ◽

Tuberculin Test ◽

First Year ◽

Test Results ◽

American Academy Of Pediatrics ◽

Tuberculin Testing ◽

First Year Of Life

In a statement from the Section on Diseases of the Chest of the American Academy of Pediatrics entitled "The Tuberculin Test,"1 the second paragraph of a comprehensive article begins as follows: "A routine tuberculin test should be performed sometime during the first year of life and annually or biennially thereafter." This recommendation for the frequency of routine tuberculin testing differs from that currently proposed by others. The same issue of Pediatrics contains an article by Dr. Phyllis Q. Edwards entitled "Tuberculin Testing of Children."2 The Summary of the article states "The pediatrician should review and analyze tuberculin test results based on his personal experience.

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National Health and Nutrition Examination Survey I, 1971-1975: Chest X-ray, Pulmonary Diffusion, and Tuberculin Test Results

ICPSR Data Holdings ◽

10.3886/icpsr08507 ◽

1987 ◽

Author(s):

Keyword(s):

National Health ◽

Tuberculin Test ◽

Nutrition Examination Survey ◽

Test Results ◽

X Ray ◽

Pulmonary Diffusion ◽

Health And Nutrition ◽

Chest X Ray

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Insufficient Sensitivity of RNA Dependent RNA Polymerase Gene of SARS-CoV-2 Viral Genome as Confirmatory Test using Korean COVID-19 Cases

10.20944/preprints202002.0424.v1 ◽

2020 ◽

Cited By ~ 10

Author(s):

Soyoun Kim ◽

Dong-Min Kim ◽

Baeckseung Lee

Keyword(s):

Diagnostic Methods ◽

Confirmatory Test ◽

Test Results ◽

Rt Pcr ◽

Viral Loads ◽

Asymptomatic Patients ◽

Pcr Method ◽

Who Guideline ◽

Rna Polymerase Gene ◽

Insufficient Sensitivity

Since mid-December of 2019, coronavirus disease 2019 (COVID-19) has been spreading from Wuhan, China. As of February 21, total 75,773 confirmed cases worldwide have spread to more than two dozen countries. Transmission of COVID-19 can occur early in the course of infection since SARS-CoV-2 viral loads in asymptomatic patients are similar to that in the symptomatic patients. Therefore, more sensitive diagnostic methods are needed to detect early phase of the infection to prevent secondary or tertiary spreads. Here, we compare the RT-PCR confirmatory test results using two different SARS-CoV-2 viral RNAs from two Korean COVID-19 confirmed cases.RT-PCR method targeting the RdRP gene, which was recommended by WHO guideline, was less sensitive than targeting N genes (as per CDC guideline). Because many countries follow the WHO guideline, our findings may contribute to the early diagnosis of COVID-19.

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Diurnal variation in SARS-CoV-2 PCR test results: Test accuracy may vary by time of day

10.1101/2021.03.12.21253015 ◽

2021 ◽

Author(s):

Candace D. McNaughton ◽

Nicholas M. Adams ◽

Carl Hirschie Johnson ◽

Michael J. Ward ◽

Thomas A. Lasko

Keyword(s):

Public Health ◽

Diurnal Variation ◽

False Negative ◽

Time Of Day ◽

Test Accuracy ◽

Test Results ◽

Clinical Tests ◽

Viral Shedding ◽

Asymptomatic Patients ◽

Polymerase Chain

AbstractFalse negative tests for SARS-CoV-2 are common and have important public health and medical implications. We tested the hypothesis that the proportion of positive SARS-CoV-2 real-time polymerase chain reaction (RT-PCR) tests varied by time of day, suggesting variation in viral shedding by time of day. Among 30,000 clinical tests performed among symptomatic and asymptomatic patients in the Vanderbilt Affiliated Healthcare Network from March-June 2020, we found evidence for diurnal variation in the proportion of positive SARS-CoV-2 tests, with a peak around 2pm in the afternoon and 2-fold variation over the day. Variation was most pronounced in outpatient and inpatient testing locations. These findings have important implications for public health testing and vaccination strategies.

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Comparison between tuberculin test results and ELISA for diagnosis of bovine tuberculosis

Journal of Veterinary Medical Research ◽

10.21608/jvmr.2007.77894 ◽

2007 ◽

Vol 17 (1) ◽

pp. 56-60

Author(s):

F. R. El-Seedy ◽

Sohair S. Elyas ◽

W. H. Hassan ◽

E. A. Nasr

Keyword(s):

Bovine Tuberculosis ◽

Tuberculin Test ◽

Test Results

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Diagnostic performance of a novel digital immunoassay (RapidTesta SARS-CoV-2): a prospective observational study with 1,127 nasopharyngeal samples

10.1101/2021.07.26.21261162 ◽

2021 ◽

Author(s):

Hiromichi Suzuki ◽

Yusaku Akashi ◽

Atsuo Ueda ◽

Yoshihiko Kiyasu ◽

Yuto Takeuchi ◽

...

Keyword(s):

Diagnostic Performance ◽

Prospective Observational Study ◽

Test Results ◽

Antigen Test ◽

Rt Pcr ◽

Asymptomatic Patients ◽

Pcr Method ◽

Antigen Tests ◽

Positive Line ◽

Test Cassette

Introduction: Digital immunoassays are generally regarded as superior tests for the detection of infectious disease pathogens, but there have been insufficient data concerning SARS-CoV-2 immunoassays. Methods: We prospectively evaluated a novel digital immunoassay (RapidTesta SARS-CoV-2). Two nasopharyngeal samples were simultaneously collected for antigen tests and RT-PCR. Real-time RT-PCR for SARS-CoV-2, using a method developed by the National Institute of Infectious Diseases, Japan, served as the reference RT-PCR method. Results: During the study period, 1,127 nasopharyngeal samples (symptomatic patients: 802, asymptomatic patients: 325) were evaluated. For digital immunoassay antigen tests, the sensitivity was 78.3% (95% CI: 67.3%-87.1%) and the specificity was 97.6% (95% CI: 96.5%-98.5%). When technicians visually analyzed the antigen test results, the sensitivity was 71.6% (95% CI: 59.9%-81.5%) and the specificity was 99.2% (95% CI: 98.5%-99.7%). Among symptomatic patients, the sensitivity was 89.4% (95% CI; 76.9%-96.5%) with digital immunoassay antigen tests, and 85.1% (95% CI; 71.7%-93.8%) with visually analyzed the antigen test, respectively. Conclusions: The findings indicated that RapidTesta SARS-CoV-2 analysis with the DIA device had sufficient analytical performance for the detection of SARS-CoV-2 in nasopharyngeal samples. When positive DIA results are recorded without a visually recognizable red line at the positive line location on the test cassette, additional RT-PCR evaluation should be performed.

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