Risk Factors for Thromboembolic Complications in Chronic Atrial Fibrillation

1990 ◽  
Vol 150 (4) ◽  
pp. 819 ◽  
Author(s):  
Palle Petersen
Kardiologiia ◽  
2019 ◽  
Vol 59 (7) ◽  
pp. 19-25
Author(s):  
Z. G. Tatarintseva ◽  
E. D. Kosmacheva ◽  
S. A. Raff ◽  
S. V. Kruchinova ◽  
V. A. Porkhanov

Aim: to elucidate risk factors of development of atrial fibrillation (AF) in patients with acute coronary syndrome (ACS), and to assess of patient’s adherence to oral anticoagulant therapy (OAT) during 12 months after ACS episode according to the data of the Total ACS Registry for the Krasnodar Territory.Materials and methods. In this retrospective analysis we used Registry data on patients with ACS and concomitant AF, consecutively admitted to cardiological departments of the S.V. Ochapovsky Territorial Clinical Hospital from 20/11/2015 to 20/02/18. Number of patients in the analyzed group was 201 (52 with AF which first appeared in connection with the index ACS). Survivors after hospital discharge were contacted by telephone and at planned visits. The analysis included assessment of rates of the following outcomes: inhospital death, hemorrhagic and thromboembolic complications, prognostic efficacy of the CRISADE and HAS BLED scores, and expediency of prescription to patients with ACS and concomitant first AF episode of prolonged OAT after hospital discharge.Results. Demographic and anamnestic data of patients with the first AF attack at the background of ACS were like those of patients with other types of AF. This group of patients was characterized by more severe course of the disease, but this produced no impact on inhospital mortality and rate of complications, as well as on mortality for 12 months after hospital discharge.Conclusion. The results of this analysis are important for understanding distinctive characteristics of patients with AF first developed during ACS.


2019 ◽  
pp. 82-91
Author(s):  
R. V. Guchaev ◽  
D. V. Pevzner ◽  
E. V. Merkulov ◽  
M. I. Makeev ◽  
N. S. Zhukova ◽  
...  

The article demonstrates a clinical case of forced renewal of anticoagulant therapy after the endovascular closure of the left atrial appendage. Patient with atrial fibrillation and high risk of thromboembolic complications and bleeding on the background of warfarin administration and inappropriate INR values had an acute hemorrhagic cerebral blood flow disorder developed. Endovascular closure of the left atrial appendage was performed. However, the thrombosis of the area of the delivery system fastening revealed after 12 months was an indication for the resumption of anticoagulant therapy.The article presents modern data on the use of occluders for closing the left atrial appendage, the frequency of complications and antiplatelet therapy schemes depending on the presence of thrombosis risk factors and bleeding.


CJEM ◽  
2018 ◽  
Vol 20 (S1) ◽  
pp. S101-S102
Author(s):  
B. H. Rowe ◽  
P. Duke ◽  
S. Patrick ◽  
K. Lobay ◽  
M. Haager ◽  
...  

Introduction: Patients with new onset and chronic atrial fibrillation and/or flutter (AFF) present to emergency departments (ED) with symptoms requiring acute management decisions. Most research has focused on patients with acute (<48 hours and/or <7 days with adequate anticoagulation) presentations of AFF and for whom rhythm control is considered safe. This study explored the demographic characteristics, risk factors, anticoagulant/anti-platelet prescription, and outcomes for patients with symptomatic AFF. Methods: A convenience sample of adult patients presenting to the one of three hospitals affiliated with the University of Alberta with symptoms of acute AFF were enrolled, within a fee-for-service billing environment. Following informed consent, a trained researcher administered a survey to each patient, recorded administrative details (e.g., triage, times, laboratory tests) from the ED information system, a chart review on treatments was conducted and patients were contacted for follow-up at 7 days via telephone. Descriptive (median and interquartile range {IQR} and proportions) and simple (t-tests, chi-square) statistics are presented for continuous and dichotomous outcomes, respectively. Results: Overall, 217 patients were enrolled; the median age was 64 (IQR: 55, 73) and 132 (61%) were male. Overall, 42 (19.4%) patients arrived by ambulance; 8 (4%) spontaneously converted or were diagnosed with another arrhythmia between arrival and obtaining an ECG. A prior history of AFF was common 152 (71%), as were the following cardiovascular and other risk factors: 176 (81.1%) consumed alcohol, 104 (48%) were current or former smokers, 86 (39.6%) had hypertension, 22 (10%) had CAD, and 10 (5%) had COPD. These patients most commonly reported palpitations 183 (84%) as their dominant symptom. Anti-platelets and anticoagulants were common prior to the ED 145 (67%), and 36 (17%) of patients were discharged from the ED without one of these medications. Overall, 80 (37%) patients had chronic AFF or an unknown timeline; no efforts were made to restore NSR in these patients. A dominant pattern for electrical cardioversion was observed; of 129 cases where cardioversion was attempted, 84 (65%) had electrical first and 45 (35%) had chemical first cardioversion attempts. Overall, 22 (49%) of 45 patients receiving chemical first were successfully converted to NSR. Patients with AFF history who were cardioverted were less likely hospitalized than those not-cardioverted (3% vs. 16%, p=0.006); 21 (10%) were admitted to hospital. Conclusion: In this center, patients with AFF often present to the ED with high acuity, with severe symptoms and receive aggressive care. The use of anticoagulants suggests an appreciation of thrombo-embolic risks, both in the community and ED settings. Like many EDs, this center appears to have a signature for AFF management, related to evidence gaps, physician preferences, and perhaps funding models.


The Lancet ◽  
1989 ◽  
Vol 333 (8631) ◽  
pp. 175-179 ◽  
Author(s):  
Palle Petersen ◽  
John Godtfredsen ◽  
Gudrun Boysen ◽  
EllenD Andersen ◽  
Bjørn Andersen

2021 ◽  
pp. 20-26
Author(s):  
O. M. Bilovol ◽  
I. I. Knyazkova

The increase in the proportion of elderly people observed in the population is accompanied by an increase in the prevalence of age-related diseases, including atrial fibrillation. In the treatment of such patients it is necessary to discuss the feasibility of prescribing anticoagulants to prevent ischemic stroke and systemic thromboembolism. The article presents scales that are used to assess the risk of thromboembolic complications and the risk of bleeding. The parameters that should be taken into account when prescribing oral anticoagulants to elderly patients are determined, the principles of bleeding risk management are given. The listed risk factors for bleeding, which are modified, potentially modified and not modified. Attention is paid to the description of specific antidotes to oral anticoagulants, the use of which has expanded in recent years, so many health professionals should know the main pharmacological effects of these drugs, be able to assess their anticoagulant effect in critical conditions and optimally cancel if necessary.


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