Parkinson's Disease Mortality in Italy, 1951 Through 1987

1993 ◽  
Vol 50 (2) ◽  
pp. 149 ◽  
Author(s):  
Adriano Chió
2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Michal Dufek ◽  
Irena Rektorova ◽  
Vojtech Thon ◽  
Jindrich Lokaj ◽  
Ivan Rektor

Objectives. The association between abnormal serum immunomarkers and mortality in 53 consecutive Parkinson’s disease patients was studied.Materials and Methods. The plasma level of specific inflammatory cytokines was investigated: mannan-binding lectin (MBL), interleukin- (IL-) 6, and tumor necrosis factor-alpha (TNF-α). The baseline serum immunomarkers obtained from patients who died (n=16) during a four-year follow-up period were compared with the data of patients who survived (n=37).Results. The baseline level of IL-6 was significantly higher in the deceased patients than in the survivors. Elevated IL-6 levels and age were major independent contributors to disease mortality. Differences between other plasma cytokine level abnormalities were not significant.Conclusion. This study showed that IL-6 elevation may be a marker of increased mortality risk in Parkinson’s disease patients. The inflammation may act in association with other factors and comorbidities in progressive neurodegenerative pathology.


2015 ◽  
Vol 72 (6) ◽  
pp. 448-455 ◽  
Author(s):  
Maartje Brouwer ◽  
Tom Koeman ◽  
Piet A van den Brandt ◽  
Hans Kromhout ◽  
Leo J Schouten ◽  
...  

2005 ◽  
Vol 20 (12) ◽  
pp. 1614-1617 ◽  
Author(s):  
Chava Peretz ◽  
Bruce H. Alexander ◽  
Sonia I. Nagahama ◽  
Karen B. Domino ◽  
Harvey Checkoway

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