Exposures and Outcomes of Children With Urticaria Seen in a Pediatric Practice-Based Research Network<subtitle>A Case-Control Study</subtitle>

Objective: To compare the prevalence of contraception in breast cancer (BC) patients at risk of unintentional pregnancy (i.e. not currently pregnant or trying to get pregnant) and matched controls. Design: The FEERIC study (Fertility, Pregnancy, Contraception after BC in France) is a prospective, multicenter case-control study. Data were collected through online questionnaires completed on the Seintinelles* research platform. Setting: Not applicable Patient(s): BC patients aged from 18 to 43 years, matched for age and parity to cancer free volunteer controls in a 1:2 ratio. Intervention(s): None Results: In a population of 1278 women at risk of unintentional pregnancy, the prevalence of contraception at study inclusion did not differ significantly between cases (340/431, 78.9%) and controls (666/847, 78.6%, p=0.97). However, the contraceptive methods used were significantly different, with a higher proportion of copper IUD use in BC survivors (59.5% versus 25.0% in controls p<0.001). For patients at risk of unintentional pregnancy, receiving information about chemotherapy induced ovary damage at BC diagnosis (OR= 2.47 95%CI [ 1.39 - 4.37] and anti-HER2 treatment (OR=2.46, 95% CI [ 1.14 - 6.16]) were significantly associated with the use of a contraception in multivariate analysis. Discussion: In this large French study, BC survivors had a prevalence of contraception use similar to that for matched controls, though almost one in five women at risk of unintentional pregnancy did not use contraception. Dedicated consultations at cancer care centers could further improve access to information and contraception counseling.

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The association between gestational weight gain z-score and stillbirth: a case-control study

BMC Pregnancy and Childbirth ◽

10.1186/s12884-019-2595-x ◽

2019 ◽

Vol 19 (1) ◽

Author(s):

Cassandra M. Pickens ◽

Carol J. Hogue ◽

Penelope P. Howards ◽

Michael R. Kramer ◽

Martina L. Badell ◽

...

Keyword(s):

Weight Gain ◽

Gestational Weight Gain ◽

Case Control Study ◽

Case Control ◽

Research Network ◽

Z Score ◽

Live Births ◽

Gestational Weight ◽

Z Scores ◽

Control Study

Abstract Background There is limited information on potentially modifiable risk factors for stillbirth, such as gestational weight gain (GWG). Our purpose was to explore the association between GWG and stillbirth using the GWG z−score. Methods We analyzed 479 stillbirths and 1601 live births from the Stillbirth Collaborative Research Network case−control study. Women with triplets or monochorionic twins were excluded from analysis. We evaluated the association between GWG z−score (modeled as a restricted cubic spline with knots at the 5th, 50th, and 95th percentiles) and stillbirth using multivariable logistic regression with generalized estimating equations, adjusting for pre − pregnancy body mass index (BMI) and other confounders. In addition, we conducted analyses stratified by pre − pregnancy BMI category (normal weight, overweight, obese). Results Mean GWG was 18.95 (SD 17.6) lb. among mothers of stillbirths and 30.89 (SD 13.3) lb. among mothers of live births; mean GWG z−score was − 0.39 (SD 1.5) among mothers of cases and − 0.17 (SD 0.9) among control mothers. In adjusted analyses, the odds of stillbirth were elevated for women with very low GWG z−scores (e.g., adjusted odds ratio (aOR) and 95% Confidence Interval (CI) for z−score − 1.5 SD versus 0 SD: 1.52 (1.30, 1.78); aOR (95% CI) for z−score − 2.5 SD versus 0 SD: 2.36 (1.74, 3.20)). Results differed slightly by pre − pregnancy BMI. The odds of stillbirth were slightly elevated among women with overweight BMI and GWG z−scores ≥1 SD (e.g., aOR (95% CI) for z−score of 1.5 SD versus 0 SD: 1.84 (0.97, 3.50)). Conclusions GWG z−scores below − 1.5 SD are associated with increased odds of stillbirth.

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The Association of Gestational Weight Gain with Stillbirth: Findings from the Stillbirth Collaborative Research Network (SCRN) Case-Control Study

Annals of Epidemiology ◽

10.1016/j.annepidem.2015.06.078 ◽

2015 ◽

Vol 25 (9) ◽

pp. 718-719 ◽

Cited By ~ 1

Author(s):

Cassandra M. Gibbs Pickens

Keyword(s):

Weight Gain ◽

Gestational Weight Gain ◽

Collaborative Research ◽

Case Control Study ◽

Case Control ◽

Research Network ◽

Gestational Weight ◽

Control Study

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Preeclampsia at delivery is associated with lower serum vitamin D and higher antiangiogenic factors: a case control study

Reproductive Biology and Endocrinology ◽

10.1186/s12958-021-00885-z ◽

2022 ◽

Vol 20 (1) ◽

Author(s):

David B. Seifer ◽

Geralyn Lambert-Messerlian ◽

Glenn E. Palomaki ◽

Robert M. Silver ◽

Corette Parker ◽

...

Keyword(s):

Vitamin D ◽

Case Control Study ◽

Serum Vitamin ◽

Case Control ◽

Maternal Serum ◽

Research Network ◽

Lower Serum ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

Control Study

Abstract Background Preeclampsia is characterized by decreased trophoblastic angiogenesis leading to abnormal invasion of spiral arteries, shallow implantation and resulting in compromised placentation with poor uteroplacental perfusion. Vitamin D plays an important role in pregnancy influencing implantation, angiogenesis and placental development. The objective of this study was to determine whether there is an association between serum vitamin D levels, and anti-angiogenic factors at the time of delivery and the occurrence of preeclampsia. Methods This nested case control study analyzed frozen serum samples at the time of delivery and related clinical data from women with singleton liveborn pregnancies who had participated in studies of the NICHD Stillbirth Collaborative Research Network. Women with a recorded finding of preeclampsia and who had received magnesium sulfate treatment prior to delivery were considered index cases (N = 56). Women without a finding of preeclampsia were controls (N = 341). Results Women with preeclampsia had 14.5% lower serum vitamin D levels than women in the control group (16.5 ng/ml vs. 19 ng/ml, p = 0.014) with 64.5% higher sFlt-1 levels (11,600 pg/ml vs. 7050 pg/ml, p < 0.001) and greater than 2 times higher endoglin levels (18.6 ng/ml vs. 8.7 ng/ml, < 0.001). After controlling for gestational age at delivery and maternal BMI, vitamin D levels were 0.88 times lower (P = 0.051), while endoglin levels were 2.5 times higher and sFlt-1 levels were 2.1 times higher than in control pregnancies (P < 0.001). Conclusions Women with preeclampsia at time of delivery have higher maternal antiangiogenetic factors and may have lower maternal serum vitamin D levels. These findings may lead to a better understanding of the underlying etiology of preeclampsia as well as possible modifiable treatment options which could include assuring adequate levels of maternal serum vitamin D prior to pregnancy.

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