Use of Tolonium Chloride in the Diagnosis of Malignant Gastric Ulcers

1978 ◽  
Vol 113 (2) ◽  
pp. 136 ◽  
Author(s):  
Shamai Giler
Keyword(s):  
Gastric Ulcers ◽  
Tolonium Chloride

Gastric Ulcers Produced by Cisplatin

1981 ◽  
Vol 39 ◽  
pp. 582-583
Author(s):  
S.K. Aggarwal ◽  
J. San Antonio
Keyword(s):  
Electron Microscopy ◽  
Single Dose ◽  
Side Effects ◽  
Antitumor Agent ◽  
Gastric Ulcers ◽  
Enzyme Cytochemistry ◽  
Intestinal Toxicity ◽  
Ovarian Cancers ◽  
Inner Surface

Cisplatin (cis-dichlorodiammineplatinum(II)) a potent antitumor agent is now available for the treatment of testicular and ovarian cancers. It is however, not free from its serious side effects including nephrotoxicity, gastro intestinal toxicity, myelosuppression, and ototoxicity. Here we now report that the drug produces peculiar bloating of the stomach in rats and induces acute ulceration.Wistar-derived rats weighing 200-250 g were administered cisplatin(9 mg/kg) ip as a single dose in 0.15 M NaCl. After 3 days the animals were sacrificed by decapitation. The stomachs were removed, the contents analyzed for pepsin and acidity. The inner surface was examined with a dissecting microscope after a moderate stretching for ulcers. Affected areas were fixed and processed for routine electron microscopy and enzyme cytochemistry.The drug treated animals kept on food and water consistently showed bloating and lesions (Fig. 1) with a frequency of 6-70 ulcers in the rumen section of the stomachs.

Effects of antisecretory agents on anglogenesis during healing of gastric ulcers

2001 ◽  
Vol 120 (5) ◽  
pp. A148-A148 ◽  
Author(s):  
M AKIMOTO ◽  
H HASHIMOTO ◽  
A MAEDA ◽  
M SHIGEMOTO ◽  
K YAMASHITA
Keyword(s):  
Gastric Ulcers

Multiple Gastric Ulcers: Their Occurrence in Benign and Malignant Lesions

1953 ◽  
Vol 25 (2) ◽  
pp. 202-217 ◽  
Author(s):  
James A. Dolphin ◽  
Lucian A. Smith ◽  
John M. Waugh
Keyword(s):  
Gastric Ulcers ◽  
Malignant Lesions

Atheromatous Embolization: a Cause of Gastric Ulcers and Small Bowel Necrosis

1964 ◽  
Vol 47 (1) ◽  
pp. 97-103 ◽  
Author(s):  
Nathan S. Taylor ◽  
Boris Gueft ◽  
Richard J. Lebowich
Keyword(s):  
Small Bowel ◽  
Gastric Ulcers ◽  
Bowel Necrosis ◽  
Small Bowel Necrosis

Gastroscopic Diagnosis in 273 Gastric Ulcers

1953 ◽  
Vol 24 (3) ◽  
pp. 328-338 ◽  
Author(s):  
Rudolf Schindler ◽  
Jean-Jacques Desneux
Keyword(s):  
Gastric Ulcers

The Time of Healing of Gastric Ulcers: Implications as to Therapy

1952 ◽  
Vol 20 (1) ◽  
pp. 20-26 ◽  
Author(s):  
Frederick Steigmann ◽  
Bernard Shulman
Keyword(s):  
Gastric Ulcers

Utility of Tolonium Chloride Rinse in the Diagnosis of Oral Cancer

2020 ◽  
Vol 26 (1) ◽  
pp. 11-17
Author(s):  
Md Kamruzzaman ◽  
Kazi Nurjahan ◽  
AS Gazi Sharifuddin ◽  
SK Ballav
Keyword(s):  
Developing Countries ◽  
Oral Cancer ◽  
Prospective Study ◽  
Diagnostic Delay ◽  
College Hospital ◽  
Female Ratio ◽  
Medical College ◽  
Biopsy Report ◽  
Patient Side ◽  
Tolonium Chloride

Background: Oral cancer burden in developing countries is huge. In Bangladesh and India incidence were 10.6% and 10.4% respectively on 2018. At the same time worldwide incident was only 2%. Majority patients present at advanced stage and their survival rate is poor. Diagnostic delay from patient side and health delivery system side is significantly longer and it is more in developing countries. Like other malignancy early diagnosis can save a lot of these patient. Methods: This prospective study was carried out in Khulna Medical College Hospital from July 2017 to July 2019. Patients who will meet the criteria for this prospective study and capable and willing to give informed consent were enrolled. 20 second rinse/gargle with 10ml of 1% Tolonium chloride solution was done. Biopsy were taken from stained lesion, biopsy report were compared with TC stained lesions. Results: Out of 1650 patients in our outdoor department for various problem and only 30 cases were selected for this study according to selection criteria. Of 30 patients, 18 (60%) were male and 12 (40%) were female. The male-to-female ratio was 3:2. It was found that the sensitivity of 1% Tolonium Chloride rinse for oral precancer and cancer detection was 83.33%, whereas the specificity was 84.21%. Conclusion: Tolonium chloride rinse is a good screening test for oral cancer diagnosis with sensitivity 83.33% and specificity 84.21%. Bangladesh J Otorhinolaryngol; April 2020; 26(1): 11-17

Antipyretic activity of the root extracts of Desmodium Gangeticum

2018 ◽  
Vol 8 (2) ◽  
pp. 20-23
Author(s):  
Raja Sheker K ◽  
Naveen B ◽  
Anil kumar A ◽  
Abhilash G
Keyword(s):  
Gastric Ulcers ◽  
Plant Leaves ◽  
Medical Systems ◽  
Human Race ◽  
Standard Drug ◽  
Root Extracts ◽  
Antipyretic Activity ◽  
Scientific Investigations ◽  
And Control ◽  
Effective Drugs

Fevers are considered as the most important parameters to evaluate and diagnose most of the disease conditions like inflammations, wounds and other infections. There are effective drugs that treat and control the fevers out of which NSAID's are most important ones. They cause notable side effects like gastric ulcers, gastric mucosal perforations etc. which make the use of those drugs limited. Herbs are used to treat various diseases, starting from the evolution of the human race. During this, herbs had been introduced to many types of tests and scientific investigations to prove the activities that herbs possess. The diseases that the herbs are used for are notable in the medical systems like Ayurveda and other systems. The need for the validation of the activities of the herbs and medicinal plants is utmost important these days. The extracts of the plant leaves of Desmodium gangeticum were extracted with ethanol and then investigated for the antipyretic activity in yeast induced pyretic method. The extract was tested in two doses 200 and 400mg/kg. This was found significant when compared to the standard drug.

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