JUSTIFIABLE ARTIFICIAL ABORTION AND INDUCED PREMATURE LABOR.

In recent years there has been an increase in the frequency of multiple pregnancies and the associated perinatal losses. It is a result of multiple pregnancy in ART refers to a high-risk gestation, at which premature births occur in 2 times more often than in singleton pregnancies. The objective: to determine the role of pro-inflammatory cytokines in the pathogenesis of premature labor in multiple pregnancy, as a result of assisted reproductive technology. Patients and methods. to determine the pro-inflammatory cytokines that all pregnant with bagtopliddyam held immunosorbent assay, defined concentrations of interleukin (IL) in serum and cervical mucus. Results. The analysis of the levels of pro-inflammatory cytokines (IL-1, IL-8) in the test environment, found high concentrations in the surveyed women with multiple pregnancy, due to the use of ART, compared with spontaneous multiple and singleton pregnancy. Increased concentration of proinflammatory cytokines in patients with multiple pregnancy by ART is associated with their synthesis at the system level, it stimulated foci of inflammation in the female genitals and extragenital localization. This correlates with the clinical data and statistical analysis, patients with multiple pregnancy as a result of ART had weighed infectious-inflammatory history. Conclusion. The study showed that elevated levels of proinflammatory cytokines in the systemic and local level in patients with multiple pregnancy due to ART, typical for women with miscarriage, because of the physiological course of pregnancy characterized by the predominance of anti-inflammatory cytokines that prevent rejection of the fetus as a foreign factor. Based on the data obtained proved the role of systemic inflammatory factors in the genesis of preterm labor in women with a multiple pregnancy, as a result of assisted reproductive technology. Key words: multiple pregnancy, assisted reproductive technology, premature birth, interleukine-1, interleukine-8.

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Modern approaches to the prevention and treatment of alterations in reproductive health in women with somatoform disorders and autonomic homeostasis

HEALTH OF WOMAN ◽

10.15574/hw.2016.116.98 ◽

2016 ◽

pp. 98-101

Author(s):

Vl.V. Podolsky ◽

◽

V.V. Podolsky ◽

Keyword(s):

Reproductive Health ◽

Hormonal Regulation ◽

Preventive Measures ◽

Somatoform Disorders ◽

Emotional Health ◽

Uterine Fibroids ◽

Reproductive Function ◽

Epidemiological Studies ◽

Prevention And Treatment ◽

Artificial Abortion

The objective: the developing of a system of preventive measures and principles of pregravid preparation for women with somatoform disorders and violation of autonomic homeostasis (VAH), in which observed changes in reproductive health (CRH) in the shape of states after undergoing artificial abortion, infertility and uterine fibroids. Patients and methods. Conducted clinical and epidemiological studies in the population of women of fertile age (WFA) allowed identifying for further examination of women with CRH in the form of state after undergoing artificial abortion, infertility and uterine fibroids in women with VAH. Further women were examined, in particular the conducted clinical and instrumental methods of research; determined the state of autonomic homeostasis and psycho emotional health of the biotopes of the organism, immunity; analyzed the hormonal regulation of the menstrual cycle; performed genetic studies and determined the morphofunctional state of reproductive system. Results. The most frequent complications during pregnancy in women who had CRH in history in the form of abortions, infertility and uterine fibroids and in the background of the PAF, there was a threat of interruption of pregnancy (often in I and II trimester – 56%) and preterm delivery (21%). The study of the catamnesis of further reproductive health found that in the case of well-conducted therapeutic measures in women undergoing artificial abortion, had infertility and uterine leiomyoma in the background of VAH, restore reproductive function, and in 82% of cases occurred a pregnancy. Conclusion. The the provided study of reproductive health, and state of various organs and systems of fertile aged women with somatoform disorders and violations of the autonomic homeostasis allowed to develop preventive measures for these women and pregravid preparation with the inclusion to the therapy Magnesium and vitamins (Magne-В6®). Key words: somatoform disorders, violation of autonomic homeostasis, changes in reproductive health, prevention and treatment, women of fertile age, Magne-В6®.

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Chemical Effects and Predictive Factors in Premature Birth

Revista de Chimie ◽

10.37358/rc.18.7.6419 ◽

2018 ◽

Vol 69 (7) ◽

pp. 1796-1801

Author(s):

Adrian Neacsu ◽

Alina Calin ◽

Anca Daniela Braila ◽

Dan Navolan ◽

Mihai Dimitriu ◽

...

Keyword(s):

Extracellular Matrix ◽

Premature Birth ◽

Tissue Concentration ◽

Premature Labor ◽

New Born ◽

Uterine Contractions ◽

Chemical Effects ◽

Equal Importance ◽

Necrosis Factor

Premature birth is considered to be the consequence of independent alterations in the cervix and in the uterus. During labor, for full-term birth, as well as for premature birth, the cervix changes, from firm, long and closed, to soft and pliable, through a biochemical process characterized by the reshaping of the extracellular matrix and a growth of the tissue concentration of inflammatory mediators; the uterus proves an increase in contractility and sensitivity to endogenic hormones, such as oxytocin. Premature labor is associated with the premature activation of the release of cytokines in the decidua (mucosa lining uterus walls) and cervix. Interleukins IL-1 beta, IL-6, IL-8 and the alpha tumoral necrosis factor increase the production and activation of matrix metalloproteinases (MMP-1, MMP-3 and MMP-9) and of cathepsin S, which digests the collagen from the extracellular matrix of the cervix, causing the wiping and softening of the cervix. These cytokines are released by leukocytes in the myometer, leading to the production of prostaglandins and oxytocin, which stimulate uterine contractions. Therefore, the cervical shortening represented by ultrasound is believed to represent premature cervical softening. The obstetrical approach of aspects related to premature birth are based, considerably, on the prognosis expected by the obstetrician regarding the survival of the premature new-born baby, as well as the therapeutic variants to be followed. And not only survival is important, of equal importance is also the quality of life of underweight, immature new-born babies, who are considerably affected both physically, and intellectually.

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I-132 3-h Thyroid Uptake in Pregnant Women at Early Gestation and after Artificial Abortion

Gynecologic and Obstetric Investigation ◽

10.1159/000303021 ◽

1966 ◽

Vol 162 (3) ◽

pp. 206-212

Author(s):

T. Górowski ◽

B. Jaroszewicz ◽

O. Chomicki ◽

Janina Gaudyn

Keyword(s):

Pregnant Women ◽

Early Gestation ◽

Thyroid Uptake ◽

Artificial Abortion

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Surgery during pregnancy – results of a German questionnaire

Innovative Surgical Sciences ◽

10.1515/iss-2020-0025 ◽

2020 ◽

Vol 5 (1-2) ◽

pp. 21-26

Author(s):

Frauke Fritze-Büttner ◽

Bettina Toth ◽

Astrid Bühren ◽

Katja Schlosser ◽

Stefanie Schierholz ◽

...

Keyword(s):

Nationwide Survey ◽

German Society ◽

Legal Regulations ◽

Premature Labor ◽

Life Balance ◽

Surgical Career ◽

Female Surgeons ◽

Leg Edema ◽

Absence From Work ◽

Operative Activity

AbstractObjectivesWorldwide, not only the number of female medical students, but also of female surgeons increases. Simultaneously, younger generations take a closer look to their work-life balance. With this in mind, it seems necessary to evaluate the expectations of female surgeons in particular with respect to pregnancy during their surgical career.MethodsTherefore, a nationwide survey was conducted in Germany from July to December 2016 under the auspices of the German Society of Surgery as well as the Professional Board of German Surgeons. The questionnaire involved 2,294 female surgeons and 1,843 complete records were evaluated.ResultsOf the analyzed answers, 62% of the women (n=781) were operating during pregnancy. The joy of surgery (91.6%), followed by team spirit (57.1%), were the main motivations to perform operations while pregnant. Operative activity decreased from 30.8% in the first 3 months of pregnancy to 21.5% during the last three months. Regarding the possible complaints, e.g., leg edema, back pain, premature labor and vaginal bleeding, there were no significant differences between the women with or without activity in the operating room. Sick leave due to pregnancy (1–10 days) was stated by 40.4% of respondents.ConclusionDespite strong legal regulations for pregnant surgeons, the survey showed that most female surgeons are eager to operate despite their pregnancy. The results also demonstrate no significant differences regarding complications during pregnancy- or pregnant-dependent absence from work. Hospitals and surgical departments are asked to establish proper working conditions for pregnant surgeons and pregnancy should not be an obstacle for a career in surgery.

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Variants in Maternal Effect Genes and Relaxed Imprinting Control in a Special Placental Mesenchymal Dysplasia Case with Mild Trophoblast Hyperplasia

Biomedicines ◽

10.3390/biomedicines9050544 ◽

2021 ◽

Vol 9 (5) ◽

pp. 544

Author(s):

Tien-Chi Huang ◽

Kung-Chao Chang ◽

Jen-Yun Chang ◽

Yi-Shan Tsai ◽

Yao-Jong Yang ◽

...

Keyword(s):

Maternal Effect ◽

Hydatidiform Mole ◽

Placental Tissue ◽

Differentially Methylated Region ◽

Normal Birth ◽

Maternal Effect Genes ◽

Common Etiology ◽

Artificial Abortion ◽

Secondary Dmr ◽

Placental Mesenchymal Dysplasia

Placental mesenchymal dysplasia (PMD) and partial hydatidiform mole (PHM) placentas share similar characteristics, such as placental overgrowth and grape-like placental tissues. Distinguishing PMD from PHM is critical because the former can result in normal birth, while the latter diagnosis will lead to artificial abortion. Aneuploidy and altered dosage of imprinted gene expression are implicated in the pathogenesis of PHM and also some of the PMD cases. Diandric triploidy is the main cause of PHM, whereas mosaic diploid androgenetic cells in the placental tissue have been associated with the formation of PMD. Here, we report a very special PMD case also presenting with trophoblast hyperplasia phenotype, which is a hallmark of PHM. This PMD placenta has a normal biparental diploid karyotype and is functionally sufficient to support normal fetal growth. We took advantage of this unique case to further dissected the potential common etiology between these two diseases. We show that the differentially methylated region (DMR) at NESP55, a secondary DMR residing in the GNAS locus, is significantly hypermethylated in the PMD placenta. Furthermore, we found heterozygous mutations in NLRP2 and homozygous variants in NLRP7 in the mother’s genome. NLRP2 and NLRP7 are known maternal effect genes, and their mutation in pregnant females affects fetal development. The variants/mutations in both genes have been associated with imprinting defects in mole formation and potentially contributed to the mild abnormal imprinting observed in this case. Finally, we identified heterozygous mutations in the X-linked ATRX gene, a known maternal–zygotic imprinting regulator in the patient. Overall, our study demonstrates that PMD and PHM may share overlapping etiologies with the defective/relaxed dosage control of imprinted genes, representing two extreme ends of a spectrum.

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