Mycoplasma pneumoniae pneumonia. Massive pulmonary involvement and pleural effusion

Abstract BACKGROUND: Analyze the clinical characteristics of Fulminant Mycoplasma pneumoniae pneumonia (FMPP), and identify the related factors predicting FMPP.METHODS: A retrospective case-control study was performed on 345 children with Mycoplasma pneumoniae pneumonia (MPP) hospitalized in our hospital from January 2017 to June 2019. The clinical features, laboratory data and radiological findings were compared between the FMPP group, refractory Mycoplasma pneumoniae pneumonia (RMPP)group and general Mycoplasma pneumoniae pneumonia (GMPP) group. RESULTS: FMPP patients (n=69) had a higher incidence of extra-pulmonary complications and more serious radiological findings(P<0.05), besides the days of fever and the days in the hospitals were longer. FMPP patients also need more complicated treatments(P<0.05). Meanwhile, the levels of white blood cell count(WBC), C-reactive protein(CRP), lactic dehydrogenase (LDH), interleukin (IL)-6, ferritin, D-dimer, fibrinogen(FG), alanine aminotransferase(ALT) and the percentage of neutrophils in the FMPP group were significantly higher than those in the RMPP group and the GMPP group (P<0.05). In ROC curve analysis, the percentage of neutrophils, WBC, CRP, LDH, IL-6, ferritin, D-dimer and ALT were contributed to identify FMPP patients. Multivariate logistic regression analysis showed that ferritin>174.15 ng/mL, IL-6>25.475pg/ml and pleural effusion have significant predictive effects on the early diagnosis of FMPP (P<0.01).CONCLUSION: FMPP patients presented more serious clinical manifestations. Ferritin>174.15 ng/mL, IL-6>25.475pg/ml and pleural effusion were clinical factors for FMPP.

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Clinical characteristics and risk factors of Fulminant Mycoplasma pneumoniae pneumonia in children

10.21203/rs.2.22954/v1 ◽

2020 ◽

Author(s):

yaoyao ling ◽

Tongqiang Zhang ◽

Zhenli Zhu ◽

Jiao Tian ◽

yongsheng xu ◽

...

Keyword(s):

Risk Factors ◽

Pleural Effusion ◽

Mycoplasma Pneumoniae ◽

Clinical Characteristics ◽

Laboratory Data ◽

Clinical Manifestations ◽

Multivariate Logistic Regression Analysis ◽

Radiological Findings ◽

Mycoplasma Pneumoniae Pneumonia ◽

D Dimer

Abstract BACKGROUND: Analyze the clinical characteristics of Fulminant Mycoplasma pneumoniae pneumonia (FMPP), and explore the related factors predicting FMPP. METHODS: A retrospective case-control study was performed on 345 children with Mycoplasma pneumoniae pneumonia (MPP) hospitalized in our Hospital from January 2017 to June 2019. The clinical features, laboratory data and radiological findings were compared between the FMPP group, refractory Mycoplasma pneumoniae pneumonia (RMPP)group and general Mycoplasma pneumoniae pneumonia (GMPP) group. RESULTS: FMPP patients (n=69) had more severe presentations, higher incidence of extra-pulmonary complications and more serious radiological findings(P<0.05). And the days of fever and the days in hospital were longer, and FMPP patients also need more complicated treatments(P<0.05). Meanwhile, the levels of white blood cell count(WBC) ,C-reactive protein(CRP), lactic dehydrogenase (LDH), interleukin (IL)-6,ferritin, D-dimer, fibrinogen(FG),alanine aminotransferase(ALT) and the percentage of neutrophils in the FMPP group were significantly higher than those in the RMPP group and the GMPP group (both P<0.05). In ROC curve analysis, the percentage of neutrophils, WBC, CRP, LDH, IL-6, ferritin, D-dimer and ALT were contributed to identify FMPP patients. Multivariate logistic regression analysis showed that ferritin>174.15 ng/mL, IL-6>25.475pg/ml and pleural effusion had significant predictive effects on the early diagnosis of FMPP (P<0.01). Conclusion: FMPP patients presented more serious clinical manifestations. Ferritin>174.15 ng/mL, IL-6>25.475pg/ml and pleural effusion were high risk factors for FMPP.

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Unexplained Dyspnea in a Young Adult with Epstein–Barr Virus Infectious Mononucleosis: Pulmonary Involvement or Co-Infection with Mycoplasma pneumoniae Pneumonia?

Journal of Clinical Medicine ◽

10.3390/jcm6090083 ◽

2017 ◽

Vol 6 (9) ◽

pp. 83

Author(s):

Burke Cunha ◽

Scarlet Herrarte Fornos

Keyword(s):

Young Adult ◽

Mycoplasma Pneumoniae ◽

Infectious Mononucleosis ◽

Epstein Barr Virus ◽

Pulmonary Involvement ◽

Barr Virus ◽

Epstein Barr ◽

Mycoplasma Pneumoniae Pneumonia

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Clinical relevance and characteristics of pleural effusion in patients with Mycoplasma pneumoniae pneumonia

Scandinavian Journal of Infectious Diseases ◽

10.3109/00365548.2012.681696 ◽

2012 ◽

Vol 44 (10) ◽

pp. 793-797 ◽

Cited By ~ 15

Author(s):

Seung-Ick Cha ◽

Kyung-Min Shin ◽

Kyung-Nyeo Jeon ◽

Seung-Soo Yoo ◽

Jaehee Lee ◽

...

Keyword(s):

Pleural Effusion ◽

Mycoplasma Pneumoniae ◽

Clinical Relevance ◽

Mycoplasma Pneumoniae Pneumonia

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Chlamydia pneumoniae and Mycoplasma pneumoniae pneumonia: comparison of clinical, epidemiological characteristics and laboratory profiles

Epidemiology and Infection ◽

10.1017/s0950268805005522 ◽

2005 ◽

Vol 134 (3) ◽

pp. 548-555 ◽

Cited By ~ 19

Author(s):

I. PULJIZ ◽

I. KUZMAN ◽

O. DAKOVIC-RODE ◽

N. SCHÖNWALD ◽

B. MISE

Keyword(s):

Pleural Effusion ◽

Mycoplasma Pneumoniae ◽

Aspartate Aminotransferase ◽

Chlamydia Pneumoniae ◽

Clinical Findings ◽

Community Acquired Pneumonia ◽

C Reactive Protein ◽

Reactive Protein ◽

Epidemiological Characteristics ◽

Mycoplasma Pneumoniae Pneumonia

The purpose of our retrospective 3-year study was to analyse and compare clinical and epidemiological characteristics in hospitalized patients older than 6 years with community-acquired pneumonia (CAP) caused by Chlamydia pneumoniae (87 patients) and Mycoplasma pneumoniae (147 patients). C. pneumoniae and M. pneumoniae infection was confirmed by serology. C. pneumoniae patients were older (42·12 vs. 24·64 years), and were less likely to have a cough, rhinitis, and hoarseness (P<0·001). C. pneumoniae patients had higher levels of C-reactive protein (CRP), and aspartate aminotransferase (AST) than M. pneumoniae patients (P<0·001). Pleural effusion was recorded more frequently in patients with M. pneumoniae (8·84 vs. 3·37%). There were no characteristic epidemiological and clinical findings that would distinguish CAP caused by M. pneumoniae from C. pneumoniae. However, some factors are indicative for C. pneumoniae such as older age, lack of cough, rhinitis, hoarseness, and higher value of CRP, and AST.

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Mycoplasma pneumoniae Pneumonia with Worsening Pleural Effusion Despite Treatment with Appropriate Antimicrobials: Case report

Sultan Qaboos University Medical Journal [SQUMJ] ◽

10.18295/squmj.2018.18.02.022 ◽

2018 ◽

Vol 18 (2) ◽

pp. 239 ◽

Cited By ~ 3

Author(s):

Kowthar S. Hassan ◽

Ghalib Al-Khadouri

Keyword(s):

Case Report ◽

Pleural Effusion ◽

Mycoplasma Pneumoniae ◽

Antimicrobial Agents ◽

Community Acquired Pneumonia ◽

University Hospital ◽

Medicine Department ◽

Sultan Qaboos University ◽

History Of ◽

Mycoplasma Pneumoniae Pneumonia

Mycoplasma pneumoniae is a common cause of community-acquired pneumonia. As M. pneumoniae pneumonia is usually a mild and self-limiting disease, complications such as pleural effusion occur only rarely. We report a 22-year-old woman who presented to the Emergency Medicine Department of the Sultan Qaboos University Hospital, Muscat, Oman, in 2017 with an eight-day history of fever associated with coughing, chills and rigors. She was diagnosed with M. pneumoniae pneumonia, but subsequently developed pleural effusion which worsened despite treatment with appropriate antimicrobials. The pleural effusion required drainage, which revealed that it was of the more severe exudative type. Following drainage, the patient improved dramatically. She was discharged and advised to continue taking antibiotics.Keywords: Mycoplasma pneumoniae; Bacterial Pneumonia; Pleural Effusion; Antimicrobial Agents; Drainage; Case Report; Oman.

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Identify clinical factors related to Mycoplasma pneumoniae pneumonia with hypoxia in children

10.21203/rs.2.22954/v3 ◽

2020 ◽

Author(s):

yaoyao ling ◽

Tongqiang Zhang ◽

wei guo ◽

Zhenli Zhu ◽

Jiao Tian ◽

...

Keyword(s):

Pleural Effusion ◽

Mycoplasma Pneumoniae ◽

Laboratory Data ◽

Clinical Manifestations ◽

Multivariate Logistic Regression Analysis ◽

Clinical Factors ◽

Radiological Findings ◽

Related Factors ◽

Mycoplasma Pneumoniae Pneumonia ◽

D Dimer

Abstract Background: Analyze the clinical characteristics of Mycoplasma pneumoniae pneumonia with hypoxia in children, and identify the related factors of hypoxia in MPP. Methods: A retrospective case-control study was performed on 345 children with Mycoplasma pneumoniae pneumonia (MPP) hospitalized in our hospital from January 2017 to June 2019. The clinical features, laboratory data and radiological findings were compared between the MPP with hypoxia, refractory Mycoplasma pneumoniae pneumonia (RMPP) and general Mycoplasma pneumoniae pneumonia (GMPP) groups. Results: MPP with hypoxia patients (n=69) had a higher incidence of extra-pulmonary complications and more serious radiological findings(P<0.05), besides the days of fever and in the hospitals were longer. And they also need more complicated treatments(P<0.05). Meanwhile, the levels of white blood cell count(WBC), C-reactive protein(CRP), lactic dehydrogenase (LDH), interleukin (IL)-6, ferritin, D-dimer, fibrinogen(FG), alanine aminotransferase(ALT) and the percentage of neutrophils in the MPP with hypoxia group were significantly higher than those in the RMPP group and the GMPP group (P<0.05). In ROC curve analysis, the percentage of neutrophils, WBC, CRP, LDH, IL-6, ferritin, D-dimer, and ALT were contributed to identify MPP with hypoxia patients. Multivariate logistic regression analysis showed that ferritin>174.15 ng/mL, IL-6>25.475pg/ml and pleural effusion had important effects on hypoxia in MPP (P<0.01).Conclusion: MPP with hypoxia patients presented more serious clinical manifestations. Ferritin>174.15 ng/mL, IL-6>25.475pg/ml and pleural effusion were related clinical factors for hypoxia in MPP.

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Chest CT Findings and Differential Diagnosis of Mycoplasma pneumoniae Pneumonia and Mycoplasma pneumoniae Combined with Streptococcal Pneumonia in Children

Journal of Healthcare Engineering ◽

10.1155/2021/8085530 ◽

2021 ◽

Vol 2021 ◽

pp. 1-10

Author(s):

Jing Wang ◽

Chen Xia ◽

Ashutosh Sharma ◽

Gurjot Singh Gaba ◽

Mohammad Shabaz

Keyword(s):

Lymph Node ◽

Pleural Effusion ◽

Mycoplasma Pneumoniae ◽

Ct Images ◽

Chest Ct ◽

Transverse Diameter ◽

Pulmonary Lesions ◽

Ct Findings ◽

Lymph Node Enlargement ◽

Mycoplasma Pneumoniae Pneumonia

Background. In this day and age, 17% of children less than 5 years of age died of pneumonia; it is the common cause of children death. It is one of the main children respiratory infectious diseases, i.e., mycoplasma pneumonia (MP). The imaging examination can be adopted to quickly observe the morphology and scope of the pulmonary lesions and know the effect of disease treatment and subsequent changes in the disease in order to provide a basis for treatment. Therefore, the most commonly applied technology for detecting pneumonia in children is imaging technology, including chest X-ray and CT. Objectives. The main objective of the work is to investigate the chest computed tomography (CT) findings of children patients with Mycoplasma pneumoniae pneumonia (MPP) and MP combined with streptococcal pneumonia (SP). The mixed infection of MP and SP is very common clinically, and the diagnosis of this type of mixed pneumonia is a critical research topic faced by pediatric respiratory physicians. The comparison is done on the incidence of bronchial and pulmonary interstitial lesions, the degree of lymph node enlargement, the volume and depth of pleural effusion, and the location and morphology of the pulmonary lesions in the chest CT images of children patients from the two groups. Methods. There were comparisons on the incidence of bronchial and pulmonary interstitial lesions, the degree of lymph node enlargement, the volume and depth of pleural effusion, and the location and morphology of the pulmonary lesions in the chest CT images of children patients from the two groups. All the experiments are done in the MATLAB. Results. The results showed that the proportions of reticular shadow, ground glass shadow, bronchial inflation phase, tube wall thickening, and vascular bundle thickening on the CT images of children patients from the MPP group were dramatically higher than those of the MP + SP group ( P < 0.05 ). The maximum transverse diameter of enlarged lymph node in children patients from the MPP group was obviously larger than the diameter of the MP + SP group ( P < 0.05 ). The number of children patients with pleural effusion was 22 in the MP + SP group, which was greatly higher than the MPP group ( P < 0.05 ). Conclusion. In conclusion, the chest CT images of children patients from the MPP group were mainly pulmonary interstitial changes. Furthermore, the alveolar inflammation could be observed on the CT images shown when children patients were combined with SP infection. The more obvious manifestations were that the flaky shadows appeared in the lungs, the pleural effusion became thicker, and the transverse diameters of enlarged lymph nodes were bigger.

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