Celiac Disease: Study of Jejunal Epithelium Before and After Gluten-Free Diet

JAMA ◽  
1963 ◽  
Vol 183 (1) ◽  
pp. 191
Keyword(s):  
Celiac Disease ◽  
Gluten Free Diet ◽  
Gluten Free ◽  
Before And After ◽  
Disease Study

scholarly journals NUTRITIONAL STATUS AND MICRONUTRIENT LEVELS OF CHILDREN WITH CELIAC DISEASE BEFORE AND AFTER GLUTEN FREE DIET

2006 ◽  
Vol 13 (01) ◽  
pp. 145-150
Author(s):  
HINA AYESHA ◽  
Muhammed Asghar Butt ◽  
MUHAMMED SHAMOON ◽  
Maqbool Ahmed ◽  
BUSHRA NAZIR ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Nutritional Status ◽  
Serum Zinc ◽  
Gluten Free Diet ◽  
Control Group ◽  
Inflammatory Disorder ◽  
Healthy Children ◽  
Gluten Free ◽  
Trace Mineral ◽  
Before And After

Introduction: Celiac disease is an autoimmune inflammatory disorder ofsmall intestine precipitated by ingestion of gluten. Clinical and histological improvement occurs on withdrawal of glutenfrom the diet. Objectives: The present study were to identify the trace mineral deficiency in newly diagnosed celiacchildren and to assess how far these deficiencies are corrected after strict gluten free diet. The study also assessedthe nutritional status of celiac children compared to the healthy controls before and after Gluten Free Diet. Setting:Department of Pediatrics Punjab Medical College Faisalabad. Duration: January 2004 to March 2005. Study Design:Interventional case control study. Patients and Methods: 22 children aged 2 to 14 years diagnosed as Celiac diseaseon the basis of typical intestinal biopsy findings were included. 15 healthy children served as controls. Anthropometricmeasurements and serum Zinc Copper Magnesium and Iron along with albumin were done for both patients andcontrols initially and repeated after 6 months while patients were receiving strict GFD and controls receiving normaldiet. The general linear model was used for the analysis of variance using SPSS (2004). Results: Serum Zinc wasbelow the reference range in 68%. Serum copper and Magnesium in 31%, Iron in 95%and albumin in 59% of thepatients. There was a statistically significant increase in serum zinc, iron and magnesium levels (p value, < 0 05) whileserum copper and albumin did not show any significant rise after Gluten free diet. Control group did not show any significant change in their trace mineral levels .Celiac patients gained more weight (mean 4.47 versus 2.91 cm) andheight (3.34cm versus 1.022 cm) as compared to the control group. Conclusion: Celiac children receiving strict Glutenfree diet and showing good clinical response probably do not need mineral supplementation.

scholarly journals CELIAC DISEASE

2016 ◽  
Vol 23 (07) ◽  
pp. 807-811
Author(s):  
Nagina Shahzadi ◽  
Muhammad Almas Hashmi ◽  
Sadida Bahawal
Keyword(s):  
Celiac Disease ◽  
Health Benefit ◽  
Gluten Free Diet ◽  
Control Group ◽  
P Value ◽  
Gluten Free ◽  
Newly Diagnosed ◽  
And Gender ◽  
Disease Study ◽  
Trial Setting

Objectives: Probiotics are alive organisms which confer health benefit whentaken at an appropriate dosage. This study was done to determine the efficacy of probiotics indecreasing the frequency of diarrhea in children with celiac disease. Study Design: Randomizedcontrolled trial. Setting: Department of Pediatrics/DHQ Allied Hospital, Faisalabad. Period:November 2011 to October 2012. Methods: Newly diagnosed patients with CD having diarrheawere included by consecutive non-probability sampling. Patients were randomized in twogroups using computer generated numbers. One group was given probiotic along with glutenfree diet while other was only prescribed gluten free diet. Reduction in frequency of diarrhea intwo groups was compared after a period of 28 days. Results: A total of 116 cases (58 in eachgroup) were enrolled. Mean age was 9.11 years. The groups were similar in age and gender ofpatients. Comparison of efficacy of probiotics in children with CD was done with control groupwhich revealed reduction in stools frequency to less than half in 86.21% (n=50) in probioticgroup but only 62.07% (n=36) in control group. P-value was 0.00015 which shows a highlysignificant difference in both groups. Conclusion: Probiotics in addition to gluten free diet arehighly effective in reducing the frequency of diarrhea in newly diagnosed patients with CD, incomparison with gluten free diet alone.

P0428 CARDIAC SYMPATHETIC AND PARASYMPATHETIC BALANCE BEFORE AND AFTER GLUTEN FREE DIET IN CHILDREN WITH CELIAC DISEASE

2004 ◽  
Vol 39 (Supplement 1) ◽  
pp. S218 ◽  
Author(s):  
M. Barbato ◽  
F. Viola ◽  
M. Curione ◽  
S. Di Bona ◽  
A. Ambrosini ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Gluten Free Diet ◽  
Gluten Free ◽  
Before And After

Endoscopic and histological findings in the duodenum of adults with celiac disease before and after changing to a gluten-free diet: a 2-year prospective study

Endoscopy ◽  
2006 ◽  
Vol 38 (7) ◽  
pp. 702-707 ◽  
Author(s):  
A. Tursi ◽  
G. Brandimarte ◽  
G. Giorgetti ◽  
W. Elisei ◽  
C. Inchingolo ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Prospective Study ◽  
Gluten Free Diet ◽  
Gluten Free ◽  
Histological Findings ◽  
Before And After

scholarly journals Cortical involvement in celiac disease before and after long-term gluten-free diet: A Transcranial Magnetic Stimulation study

PLoS ONE ◽  
2017 ◽  
Vol 12 (5) ◽  
pp. e0177560 ◽  
Author(s):  
Manuela Pennisi ◽  
Giuseppe Lanza ◽  
Mariagiovanna Cantone ◽  
Riccardo Ricceri ◽  
Raffaele Ferri ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Transcranial Magnetic Stimulation ◽  
Magnetic Stimulation ◽  
Gluten Free Diet ◽  
Gluten Free ◽  
Before And After ◽  
Cortical Involvement

BMI assessment in children with celiac disease before and after gluten free diet

2015 ◽  
Vol 47 ◽  
pp. e244
Author(s):  
G.A. Mazza ◽  
V. Talarico ◽  
M. Barreca ◽  
S. Lavano ◽  
R. Miniero ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Gluten Free Diet ◽  
Gluten Free ◽  
Before And After

Motility Alterations in Celiac Disease and Non-Celiac Gluten Sensitivity

2015 ◽  
Vol 33 (2) ◽  
pp. 200-207 ◽  
Author(s):  
Maria Ines Pinto-Sanchez ◽  
Premysl Bercik ◽  
Elena F. Verdu
Keyword(s):  
Celiac Disease ◽  
Functional Characterization ◽  
Disease Process ◽  
Gastrointestinal Transit ◽  
Gluten Free Diet ◽  
Low Grade ◽  
Gluten Sensitivity ◽  
Gluten Free ◽  
Gliadin Antibodies ◽  
Before And After

Regulation of gut motility is complex and involves neuromuscular, immune and environmental mechanisms. It is well established that patients with celiac disease (CD) often display gut dysmotility. Studies have shown the presence of disturbed esophageal motility, altered gastric emptying, and dysmotility of the small intestine, gallbladder and colon in untreated CD. Most of these motor abnormalities resolve after a strict gluten-free diet, suggesting that mechanisms related to the inflammatory condition and disease process are responsible for the motor dysfunction. Motility abnormalities are also a hallmark of functional bowel disorders such as irritable bowel syndrome (IBS), where it has been proposed as underlying mechanism for symptom generation (diarrhea, constipation, bloating). Non-celiac gluten sensitivity (NCGS) is a poorly defined entity, mostly self-diagnosed, that presents clinically with IBS symptoms in the absence of specific celiac markers. Patients with NCGS are believed to react symptomatically to wheat components, and some studies have proposed the presence of low-grade inflammation in these patients. There is little information regarding the functional characterization of these patients before and after a gluten-free diet. A study suggested the presence of altered gastrointestinal transit in NCGS patients who also have a high prevalence of nonspecific anti-gliadin antibodies. Results of an ongoing clinical study in NCGS patients with positive anti-gliadin antibodies before and after a gluten-free diet will be discussed. Elucidating the mechanisms for symptom generation in NCGS patients is important to find new therapeutic alternatives to the burden of imposing a strict gluten-free diet in patients who do not have CD.

scholarly journals Subtypes of chronic gastritis in patients with celiac disease before and after gluten‐free diet

2017 ◽  
Vol 5 (6) ◽  
pp. 805-810 ◽  
Author(s):  
Dolores Gabrieli ◽  
Fabiana Ciccone ◽  
Annalisa Capannolo ◽  
Angelo Viscido ◽  
Giorgio Valerii ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Chronic Gastritis ◽  
Gluten Free Diet ◽  
Gluten Free ◽  
Before And After

scholarly journals Evaluation of Gluten-Free Diet Efficacy for Improving Quality of Life of Patients with Celiac Disease

2021 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Pezhman Alavinejad ◽  
Yosra Shafiolleh Talokdar ◽  
Zahra Shokati Ashkiki
Keyword(s):  
Quality Of Life ◽  
Celiac Disease ◽  
Cross Sectional Study ◽  
Gluten Free Diet ◽  
Gluten Free ◽  
Cross Sectional ◽  
Khuzestan Province ◽  
Before And After ◽  
One Year

Background: As the only effective treatment of celiac disease (CD) is a lifelong commitment to a gluten-free diet (GFD), this study was designed to evaluate the efficacy of GFD in the quality of life (QOL) of patients with CD to persuade them for strict commitment. Methods: In a cross-sectional study, the QOL of CD patients registered in the celiac society of Khuzestan province was evaluated and compared before and at least one year after commencing GFD using the QOL SF-36 questionnaire. Results: Overall, 200 CD patients (66 males and 134 females) were evaluated. The average age of male and female participants was 26.3 and 30.34 years, respectively (61% between 20 and 60-years-old). After GFD, complaints such as bloating (P = 0.001), abdominal pain (P = 0.001), diarrhea (P = 0.001), nausea (P = 0.001), vomiting (P = 0.03), reflux and regurgitation (P = 0.025), anorexia (P = 0.001), fatigue (P = 0.001), headache (P = 0.008), oral aphthous lesions (P = 0.014), weight loss (P = 0.001), and bone pain (P = 0.005) significantly improved while other symptoms such as muscular pain (P = 0.157), dermatitis (P = 0.083), and numbness (P = 0.317) did not show any major improvement. The average scores of QOL before and after GFD were 0.74 and 3.41, respectively, which demonstrated significant improvement (P = 0.001). This improvement was even seen among cases with sub-optimal compliance (average QOL score 3.28, P = 0.001). Conclusion: A gluten-free diet could significantly improve the quality of life of patients with celiac disease, and they should be encouraged as much as possible to be committed to this regimen.

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