The Effect of Cortisone on Peptic Ulcer Formation

JAMA ◽  
1963 ◽  
Vol 183 (12) ◽  
Author(s):  
Demetre M. Nicoloff ◽  
Henry Sosin ◽  
Edward T. Peter ◽  
Arnold S. Leonard ◽  
Owen H. Wangensteen
Keyword(s):  
Peptic Ulcer ◽  
Ulcer Formation

The Relation of Pancreatic Secretion to Peptic Ulcer Formation

1950 ◽  
Vol 16 (2) ◽  
pp. 490-494 ◽  
Author(s):  
Edgar J. Poth ◽  
Stanley M. Fromm
Keyword(s):  
Peptic Ulcer ◽  
Pancreatic Secretion ◽  
Ulcer Formation

scholarly journals Prevention of peptic ulcer by aqueous extract of Aegle marmelos leaf in rats

2018 ◽  
Vol 12 (1) ◽  
pp. 11-14
Author(s):  
Sharmin Rahman ◽  
Mohammad Rezaul Quader ◽  
Md Ismail Khan
Keyword(s):  
Body Weight ◽  
Peptic Ulcer ◽  
Gastric Ulcer ◽  
Aqueous Extract ◽  
Protective Efficacy ◽  
Albino Rats ◽  
Ulcer Formation ◽  
Aegle Marmelos ◽  
Rat Stomach ◽  
Dose Dependent

Background and objectives: Aegle marmelos (Bael), a medicinal plant, has been widely used indigenously to treat many diseases in Bangladesh and other countries. The present study was carried out to evaluate the efficacy of A. marmelos leaf to prevent ethanol induced gastric ulcer in a rat model.Methods: Thirty two Wister albino rats of either sex, weighing between 100-150g, were fed 200 mg/kg or 400 mg/kg aqueous extract of A. marmelos leaves one hour prior to oral administration of 90% ethanol (1 ml/200 gm body weight) to induce gastric ulcer. The animals were sacrificed after one hour and ulcer scores and index were determined. The protective efficacy of A. marmelos aqueous extract was expressed as percentage protection of ulcer.Results: Aqueous extract exhibited significant (p<0.05) dose dependent protection against gastric ulcer formation by ethanol in rat stomach. Percentage protection of ulcer with 200 mg/kg and 400 mg/kg of aqueous extract of A. marmelos leave were 19.3% and 37.2% respectively compared to standard anti-peptic ulcer drug omeprazole (50.4%).Conclusion: Thus, crude extracts of A. marmelos leave have been shown to have potential ability to prevent experimentally induced peptic ulcer formation in animal model.IMC J Med Sci 2018; 12(1): 11-14

scholarly journals Evaluation of a poly-herbal preparation for the treatment of peptic ulcer

2017 ◽  
Vol 12 (2) ◽  
pp. 11
Author(s):  
Zaman Hayat ◽  
Mueen Ahmad Chaudhry ◽  
. Alamgeer
Keyword(s):  
Peptic Ulcer ◽  
Gastric Ulcer ◽  
Treated Group ◽  
Ulcer Formation ◽  
Ulcer Index ◽  
Herbal Formulation ◽  
High K ◽  
Ulcer Model ◽  
Dose Dependent ◽  
Gross Examination

<p class="Abstract">The aim of this study was to validate the traditional uses of ulcerene, a poly-herbal formulation in ethanol, aspirin and stress-induced gastric ulcer model of rat. The extent of gastric ulcer formation was studied, using ulcer score, ulcer index, percentage cure through gross examination and histopathological evaluation. A significant (p&lt;0.001) dose-dependent anti-ulcerant effect was observed in ulcerene (50 and 100 mg/kg)-treated group with highest effectiveness against ethanol-induced ulcer. The concentration-dependent spasmolytic effect was seen in spontaneously contracting, high K<sup>+</sup> (80 mM) and carbachol (1 µM)-induced jejunum contractions (10, 0.3 and 1 mg/mL), similar to dicyclomine (10, 1 and 3 µM), indicated non-specific spasmolytic mechanism behind the effect. By considering these results, ulcerene can be suggested for the treatment of peptic ulcer.</p>

The Influence of Caerulein-Like Peptides on Gastric Secretion and Peptic Ulcer Formation in Cats

Digestion ◽  
1972 ◽  
Vol 5 (1) ◽  
pp. 1-8 ◽  
Author(s):  
S.J. Konturek ◽  
T. Radecki ◽  
J. Biernat ◽  
P. Thor
Keyword(s):  
Peptic Ulcer ◽  
Gastric Secretion ◽  
Ulcer Formation

Effect of glucagon on gastric and pancreatic secretion and peptic ulcer formation in cats

1974 ◽  
Vol 19 (6) ◽  
pp. 557-564 ◽  
Author(s):  
Stanislaw J. Konturek ◽  
Teresa Demitrescu ◽  
Tedeusz Radecki ◽  
Piotr Thor ◽  
Anna Pucher
Keyword(s):  
Peptic Ulcer ◽  
Pancreatic Secretion ◽  
Ulcer Formation

Comparison of Effects of Metiamide and Atropine on Gastric and Pancreatic Secretion and Peptic Ulcer Formation in Cat

Digestion ◽  
1974 ◽  
Vol 10 (4-5) ◽  
pp. 267-281 ◽  
Author(s):  
S.J. Konturek ◽  
T. Radecki ◽  
T. Demitrescu ◽  
A. Dembinski
Keyword(s):  
Peptic Ulcer ◽  
Pancreatic Secretion ◽  
Ulcer Formation

scholarly journals EVALUATION OF GASTROPROTECTIVE EFFECT OF COENZYME Q 10 AND L - GLUTAMINE IN STRESS AND ETHANOL-INDUCED PEPTIC ULCER IN WISTAR RATS: A NOVEL PRECLINICAL STUDY

2018 ◽  
Vol 11 (9) ◽  
pp. 365
Author(s):  
Balaji Ommurugan ◽  
Shalini Adiga ◽  
Vijetha Shenoy Belle
Keyword(s):  
Peptic Ulcer ◽  
Coenzyme Q ◽  
Antioxidant Property ◽  
Preclinical Study ◽  
Experimental Models ◽  
Ulcer Formation ◽  
Peptic Ulcers ◽  
Ulcer Disease ◽  
Ulcer Model ◽  
Post Hoc

Objective: Coenzyme Q 10 (CoQ10) and L-glutamine have antioxidant property their role in peptic ulcer diseases is not well known. Hence, the aim of present study is to evaluate the gastroprotective role of CoQ10 and L-glutamine in stress and ethanol-induced peptic ulcers in Wistar albino rats.Methods: A total of 90 rats were used for the conduct of study in two experimental models, the stress- and the ethanol-induced ulcer model. Each model consists of eight groups with six rats in each group. Sucralfate and pantoprazole were used as standard drugs along with CoQ10 and L- glutamine as test drugs. Drugs were administered for 10 days in stress model and 7 days in case of ethanol model. Statistically analyzed using analysis of variance and post-hoc test with significance as p>0.05Results: CoQ10 and L- glutamine when used alone as well in combination with pantoprazole and sucralfate showed no ulcer formation. Test drugs showed decrease in gastric acid secretion, decreased total and free acidity levels, higher gastric pH, increased mucous secreting ability, higher levels of reduced glutathione levels in both tissue as well as blood and lower malondialdehyde levels when compared with pantoprazole and sucralfate suggestive of their antioxidative benefit, in both the models.Conclusion: Well-designed clinical trials can be done to evaluate the use of CoQ10 and L- glutamine in the treatment of peptic ulcer disease due to various etiology.

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