Animal Models for Infectious Diseases

2011 ◽  
Author(s):  
Ethan M. Shevach
Keyword(s):  
Animal Models ◽  
Infectious Diseases

scholarly journals INTRODUCTION: Immune Relevant Animal Models: Opportunities and Challenges

ILAR Journal ◽  
2018 ◽  
Vol 59 (3) ◽  
pp. 209-210
Author(s):  
Gregers Jungersen ◽  
Jorge Piedrahita
Keyword(s):  
Immune System ◽  
T Cell ◽  
Animal Models ◽  
Infectious Diseases ◽  
Tissue Specific ◽  
Car T Cell ◽  
Car T ◽  
Preclinical Animal Models

Abstract Valid interpretation of preclinical animal models in immunology-related clinical challenges is important to solve outstanding clinical needs. Given the overall complexity of the immune system and both species- and tissue-specific immune peculiarities, the selection and design of appropriate immune-relevant animal models is, however, not following a straightforward path. The topics in this issue of the ILAR Journal provide assessments of immune-relevant animal models used in oncology, hematopoietic-, CAR-T cell- and xenotransplantation, adjuvants and infectious diseases, and immune privileged inflammation that are providing key insights into unmet human clinical needs.

scholarly journals Imaging of Small-Animal Models of Infectious Diseases

2013 ◽  
Vol 182 (2) ◽  
pp. 296-304 ◽  
Author(s):  
Linda A. Jelicks ◽  
Michael P. Lisanti ◽  
Fabiana S. Machado ◽  
Louis M. Weiss ◽  
Herbert B. Tanowitz ◽  
...  
Keyword(s):  
Animal Models ◽  
Infectious Diseases ◽  
Small Animal ◽  
Small Animal Models

scholarly journals The science and medicine of human immunology

Science ◽  
2020 ◽  
Vol 369 (6511) ◽  
pp. eaay4014
Author(s):  
Bali Pulendran ◽  
Mark M. Davis
Keyword(s):  
Immune System ◽  
Animal Models ◽  
Infectious Diseases ◽  
Autoimmune Diseases ◽  
Inbred Mice ◽  
Human Immune System ◽  
Human Immunology ◽  
Human Immune ◽  
Mechanistic Understanding ◽  
New Strategies

Although the development of effective vaccines has saved countless lives from infectious diseases, the basic workings of the human immune system are complex and have required the development of animal models, such as inbred mice, to define mechanisms of immunity. More recently, new strategies and technologies have been developed to directly explore the human immune system with unprecedented precision. We discuss how these approaches are advancing our mechanistic understanding of human immunology and are facilitating the development of vaccines and therapeutics for infection, autoimmune diseases, and cancer.

scholarly journals Recombinant Varicella-Zoster Virus Vaccines as Platforms for Expression of Foreign Antigens

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Wayne L. Gray
Keyword(s):  
Older Adults ◽  
Animal Models ◽  
Infectious Diseases ◽  
Varicella Zoster Virus ◽  
The Elderly ◽  
Recombinant Vaccines ◽  
Varicella Zoster

Varicella-zoster virus (VZV) vaccines induce immunity against childhood chickenpox and against shingles in older adults. The safety, efficacy, and widespread use of VZV vaccines suggest that they may also be effective as recombinant vaccines against other infectious diseases that affect the young and the elderly. The generation of recombinant VZV vaccines and their evaluation in animal models are reviewed. The potential advantages and limitations of recombinant VZV vaccines are addressed.

scholarly journals Effect of Malnutrition on K+ Current in T Lymphocytes

2005 ◽  
Vol 12 (7) ◽  
pp. 808-813 ◽  
Author(s):  
Rafael Godínez Fernández ◽  
Joaquín Azpiroz Leehan ◽  
Reyna Fierro Pastrana ◽  
Rocío Ortíz Muñiz
Keyword(s):  
Membrane Potential ◽  
T Lymphocytes ◽  
Animal Models ◽  
Potassium Channels ◽  
Infectious Diseases ◽  
Severe Malnutrition ◽  
Voltage Dependent ◽  
K Current

ABSTRACT Severe malnutrition in children is frequently associated with infectious diseases. Animal models have been useful for studying the effects of malnutrition. One of the immunosuppressive mechanisms of malnutrition is inhibition of the activation of T lymphocytes. The voltage-dependent K(V) potassium channels are vital for the activation of T lymphocytes. The blockade of K(V) channels inhibits the activation of T lymphocytes. Malnutrition could affect the suitable synthesis of K(V) channels in T lymphocytes, producing changes in the magnitude and/or dependency of the voltage of the K+ current. We reported a significant decrease in the K+ current and activation to a 20 mV more positive membrane potential in T lymphocytes of rats with severe malnutrition. These results indicate that the diminution in the K+ conductance by alteration of K(V) channels in severe malnutrition is one of the mechanisms that inhibit the activation of T lymphocytes.

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