scholarly journals Inactivation of gilGT , Encoding a C‐ Glycosyltransferase, and gilOIII , Encoding a P450 Enzyme, Allows the Details of the Late Biosynthetic Pathway to Gilvocarcin V to be Delineated

ChemBioChem ◽  
2006 ◽  
Vol 7 (7) ◽  
pp. 1070-1077 ◽  
Author(s):  
Tao Liu ◽  
Madan Kumar Kharel ◽  
Carsten Fischer ◽  
Andrew McCormick ◽  
Jürgen Rohr
Keyword(s):  
Biosynthetic Pathway ◽  
P450 Enzyme ◽  
Gilvocarcin V

Oxidative Rearrangement Processes in the Biosynthesis of Gilvocarcin V

2004 ◽  
Vol 126 (39) ◽  
pp. 12262-12263 ◽  
Author(s):  
Tao Liu ◽  
Carsten Fischer ◽  
Claus Beninga ◽  
Jürgen Rohr
Keyword(s):  
Oxidative Rearrangement ◽  
Gilvocarcin V ◽  
Rearrangement Processes

INHIBITION OF Herpes virus PLAQUING CAPACITY IN HUMAN DIPLOID FIBROBLASTS TREATED WITH GILVOCARCIN V PLUS NEAR UV RADIATION

1990 ◽  
Vol 51 (4) ◽  
pp. 477-479 ◽  
Author(s):  
L. E. Bockstahler ◽  
R. K. Elespuru ◽  
V. M. Hitchins ◽  
P. G. Carney ◽  
K. M. Olvey ◽  
...  
Keyword(s):  
Uv Radiation ◽  
Herpes Virus ◽  
Diploid Fibroblasts ◽  
Human Diploid Fibroblasts ◽  
Herpès Virus ◽  
Gilvocarcin V

scholarly journals Synthetic study of ravidomycin, a hybrid natural product

2000 ◽  
Vol 72 (9) ◽  
pp. 1783-1786 ◽  
Author(s):  
Keisuke Suzuki
Keyword(s):  
Natural Products ◽  
Total Synthesis ◽  
Natural Product ◽  
Amino Sugar ◽  
Antitumor Antibiotics ◽  
Ready Availability ◽  
Silyl Acetals ◽  
Gilvocarcin V ◽  
Absolute Stereochemistry

Strategies and tactics associated with the total synthesis of hybrid natural products are discussed. The target is ravidomycin (2), one of the gilvocarcin-class antitumor antibiotics with an aryl C-glycoside structure. The first total synthesis of 2, which was achieved along similar lines of that of gilvocarcin V (1), served for the determination of the relative as well as the absolute stereochemistry of 2. Also revealed was a limitation of the synthetic scheme so long as the amino sugar congener was concerned. A preliminary result is discussed on the [2+2+2] approach that relies on the ready availability of various benzocyclobutene derivatives via regioselective [2+2] cycloaddition of α-alkoxybenzynes and ketene silyl acetals.

scholarly journals Nitrogen repression of gilvocarcin V production in Streptomyces arenae 2064.

1986 ◽  
Vol 39 (4) ◽  
pp. 594-600 ◽  
Author(s):  
KEVIN M. BYRNE ◽  
MICHAEL GREENSTEIN
Keyword(s):  
Nitrogen Repression ◽  
Gilvocarcin V
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