Interventions for preventing non-melanoma skin cancers in high-risk groups

The mainstay of curative therapy for head and neck skin cancers relies upon surgery and/or radiation therapy. However, for some aggressive, non-resectable or recurrent tumors, systemic therapy is necessary. Recent emerging classes of drugs have shown to improve survival for high-risk, recurrent, and unresectable variants of these tumors. The goal of this paper is to review options for systemic therapies for head and neck skin cancers including melanoma, non-melanoma skin cancers and other rare and non-malignant tumors.

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Treatment of Multiple Actinic Keratosis and Field of Cancerization with Topical Piroxicam 0.8% and Sunscreen 50+ in Organ Transplant Recipients: A Series of 10 Cases

Case Reports in Dermatology ◽

10.1159/000481770 ◽

2017 ◽

Vol 9 (3) ◽

pp. 211-216 ◽

Cited By ~ 13

Author(s):

Virginia Garofalo ◽

Alessandra Ventura ◽

Sara Mazzilli ◽

Laura Diluvio ◽

Luca Bianchi ◽

...

Keyword(s):

High Risk ◽

Skin Cancer ◽

Cell Carcinoma ◽

Medical Device ◽

Actinic Keratosis ◽

Organ Transplant ◽

Cyclooxygenase Inhibitors ◽

Organ Transplant Recipient ◽

Skin Cancers ◽

Melanoma Skin

Organ transplant recipient (OTR) subjects are at high risk of skin cancer such as squamous cell carcinoma and basal cell carcinoma. Actinic keratosis (AK) is considered the precursor of these non-melanoma skin cancers. Sun protection is mandatory in subjects with AK and this preventive strategy is very important in OTR. Treatment of the field of cancerization is also crucial to reduce the risk of recurrence of skin lesions in AK and non-melanoma skin cancer patients. Activation of cyclooxygenase 1 and 2 enzymes plays an important role in the pathogenesis of skin cancers. Topical application of cyclooxygenase inhibitors such as diclofenac and, more recently, piroxicam has shown to reduce AK lesions in immunocompetent subjects. A medical device containing piroxicam and SPF 50+ sunscreen filters (P+SS) has been demonstrated to be effective in reducing AK lesions and improving the field of cancerization. We report the effect of P+SS, applied for 16 weeks, in a case series of 10 OTR subjects with multiple AK lesions. P+SS treatment was associated with a relevant AK lesion reduction (>75%) in 7 patients (with a complete clearance in 3 subjects) with an improvement in the field of cancerization. This medical device could be considered a promising long-term curative and preventive treatment in OTR patients at high risk of non-melanoma skin cancers.

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α-HPV positivity analysis in a group of patients with melanoma and non-melanoma skin cancers / Analiza pozitivităţii α-HPV la un grup de pacienţi cu tumori cutanate melanocitare şi non-melanocitare

Revista Romana de Medicina de Laborator ◽

10.2478/rrlm-2014-0044 ◽

2014 ◽

Vol 22 (4) ◽

Author(s):

Maria Rotaru ◽

Gabriela Iancu ◽

Manuela Mihalache ◽

Gabriela Anton ◽

Silviu Morariu

Keyword(s):

High Risk ◽

Cell Carcinoma ◽

Control Group ◽

Continuous Increase ◽

Hpv Dna ◽

Skin Cancers ◽

Hpv Genotypes ◽

Polymerase Chain ◽

High Risk Hpv ◽

Melanoma Skin

AbstractBackground. Medical research has shown a continuous increase in the incidence of skin cancers, especially among young individuals. One of the ethiopathogenic factors that cause skin carcinogenesis could be the infection with some genotypes of human papillomavirus (HPV). Methods. In our study, we have analyzed alpha (α) - HPV positivity and HPV genotypes identified in melanocytic (MSC) and nonmelanocytic skin cancers (NMSC). The results were then compared with results obtained from the control group. The study included 40 cases of MSC and NMSC found in the data base of our hospital, and 40 healthy patients. In all of the cases, we identified the HPV DNA by using polymerase chain reaction (PCR), and the viral genotypes by using α -HPV primers by Linear Array Roche kit. Results. The average α-HPV positivity in tumors was 32.50%, higher than in other studies published to date. The squamous cell carcinoma (SCC) lot had the highest α-HPV positivity (40%), followed by basal cell carcinoma (BCC) (35%) and malignant melanoma (MM) (20%). The comparative analysis between skin cancer-HPV positive (32.50%) and the control group-HPV positive (15%) revealed a positivity of HPV in the tumors group (32.50%) that was higher by a ratio of 2.16. By viral genotyping, we identified high-risk HPV only in BCC and MM (in all α-HPV samples), but not in SCC samples. Conclusions. In our study, α-HPV in NMSC and MSC was positive in 32.50% of the cases; in 46.15% of these, it was possible to identify HPV genotypes. The high-risk HPV genotypes observed in these patients were HPV 16, 35, 58 and 59.

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Suicide in Nógrád County, Hungary, 1970-1994

Crisis ◽

10.1027//0227-5910.20.2.64 ◽

1999 ◽

Vol 20 (2) ◽

pp. 64-70 ◽

Cited By ~ 5

Author(s):

Tamás Zonda

Keyword(s):

High Risk ◽

Psychiatric Disorders ◽

Suicide Rate ◽

Risk Groups ◽

The Elderly ◽

Female Ratio ◽

Suicide Notes ◽

Suicidal Intention ◽

Male Female Ratio

The author examined completed suicides occurring over a period of 25 years in a county of Hungary with a traditionally low (relatively speaking) suicide rate of 25.8. The rates are clearly higher in villages than in the towns. The male/female ratio was close to 4:1, among elderly though only 1.5:1. The high risk groups are the elderly, divorced, and widowed. Violent methods are chosen in 66.4% of the cases. The rates are particularly high in the period April-July. Prior communication of suicidal intention was revealed in 16.3% of all cases. Previous attempts had been undertaken by 17%, which in turn means that 83% of suicides were first attempts. In our material 10% the victims left suicide notes. Psychiatric disorders were present in 60.1% of the cases, and severe, multiple somatic illnesses (including malignomas) were present in 8.8%. The majority of the data resemble those found in the literature.

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Latest APA Survey Reveals Deepening Concerns About Connection Between Chronic Disease and Stress: Psychologists warn of a rising public health dilemma, especially for high-risk groups

PsycEXTRA Dataset ◽

10.1037/e683522012-001 ◽

2012 ◽

Keyword(s):

Public Health ◽

Chronic Disease ◽

High Risk ◽

Risk Groups

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Skull Base and Intracranial Invasion Patterns and Survival Outcomes of Non-Melanoma Skin Cancers

Journal of Neurological Surgery Part B Skull Base ◽

10.1055/s-0036-1579792 ◽

2016 ◽

Vol 77 (S 01) ◽

Author(s):

Yusuf Dundar ◽

Richard Cannon ◽

Marcus Monroe ◽

Luke Buckman ◽

Jason Hunt

Keyword(s):

Skull Base ◽

Survival Outcomes ◽

Skin Cancers ◽

Invasion Patterns ◽

Melanoma Skin

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A(H1N1)v cases of the 2009/2010 and 2010/2011 influenza seasons in the Medical and Health Sciences Centre of Debrecen University

Orvosi Hetilap ◽

10.1556/oh.2012.29329 ◽

2012 ◽

Vol 153 (17) ◽

pp. 649-654

Author(s):

Piroska Orosi ◽

Judit Szidor ◽

Tünde Tóthné Tóth ◽

József Kónya

Keyword(s):

High Risk ◽

Influenza Season ◽

National Level ◽

Organ Transplant ◽

High Risk Patient ◽

Risk Groups ◽

Health Sciences ◽

World Health ◽

Transplant Patients ◽

Health Organization

The swine-origin new influenza variant A(H1N1) emerged in 2009 and changed the epidemiology of the 2009/2010 influenza season globally and at national level. Aims: The aim of the authors was to analyse the cases of two influenza seasons. Methods: The Medical and Health Sciences Centre of Debrecen University has 1690 beds with 85 000 patients admitted per year. The diagnosis of influenza was conducted using real-time polymerase chain reaction in the microbiological laboratories of the University and the National Epidemiological Centre, according to the recommendation of the World Health Organization. Results: The incidence of influenza was not higher than that observed in the previous season, but two high-risk patient groups were identified: pregnant women and patients with immunodeficiency (oncohematological and organ transplant patients). The influenza vaccine, which is free for high-risk groups and health care workers in Hungary, appeared to be effective for prevention, because in the 2010/2011 influenza season none of the 58 patients who were administered the vaccination developed influenza. Conclusion: It is an important task to protect oncohematological and organ transplant patients. Orv. Hetil., 2012, 153, 649–654.

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