Infection control strategies for preventing the transmission of methicillin-resistant Staphylococcus aureus in nursing homes and associated older residents

2007 ◽  
Author(s):  
CM Hughes ◽  
MBH Smith ◽  
MM Tunney
Keyword(s):  
Staphylococcus Aureus ◽  
Nursing Homes ◽  
Infection Control ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Control Strategies ◽  
Methicillin Resistant

Intersection of HIV and community-associated methicillin-resistant Staphylococcus aureus

2020 ◽  
Vol 15 (1) ◽  
pp. 53-65
Author(s):  
Kyle J Popovich
Keyword(s):  
Staphylococcus Aureus ◽  
Infection Control ◽  
Infection Prevention ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Control Strategies ◽  
Community Settings ◽  
Methicillin Resistant ◽  
The Past ◽  
Healthcare Settings ◽  
Increased Risk

The epidemiology of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) has evolved over the past approximately 20 years, with certain populations appearing to have disproportionate risk. Of concern is the potential worsening of S. aureus infections in light of the continued opioid crisis. This review will discuss how CA-MRSA has significantly impacted HIV-infected individuals and address additional factors and populations that are associated with increased risk for MRSA. It will review therapeutic options and infection control strategies as well as highlight how whole genome sequencing can be used to extend traditional epidemiologic analysis and ultimately, inform infection prevention efforts. Continued work identifying those at the highest risk for MRSA, what the best infection prevention settings are in community settings and how to effectively implement and target these strategies is needed. Ultimately, infection control efforts will likely need to extend beyond healthcare settings to effectively and sustainably reduce MRSA infections.

scholarly journals The Role of ArlRS and VraSR in Regulating Ceftaroline Hypersusceptibility in Methicillin-Resistant Staphylococcus aureus

Antibiotics ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 821
Author(s):  
Maite Villanueva ◽  
Melanie Roch ◽  
Iñigo Lasa ◽  
Adriana Renzoni ◽  
William L. Kelley
Keyword(s):  
Staphylococcus Aureus ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Control Strategies ◽  
Population Analysis ◽  
Methicillin Resistant ◽  
Signal Systems ◽  
Fifth Generation ◽  
Sensing Systems ◽  
Two Component ◽  
Two Component Systems

Methicillin-resistant Staphylococcus aureus infections are a global health problem. New control strategies, including fifth-generation cephalosporins such as ceftaroline, have been developed, however rare sporadic resistance has been reported. Our study aimed to determine whether disruption of two-component environmental signal systems detectably led to enhanced susceptibility to ceftaroline in S. aureus CA-MRSA strain MW2 at sub-MIC concentrations where cells normally continue to grow. A collection of sequential mutants in all fifteen S. aureus non-essential two-component systems (TCS) was first screened for ceftaroline sub-MIC susceptibility, using the spot population analysis profile method. We discovered a role for both ArlRS and VraSR TCS as determinants responsible for MW2 survival in the presence of sub-MIC ceftaroline. Subsequent analysis showed that dual disruption of both arlRS and vraSR resulted in a very strong ceftaroline hypersensitivity phenotype. Genetic complementation analysis confirmed these results and further revealed that arlRS and vraSR likely regulate some common pathway(s) yet to be determined. Our study shows that S. aureus uses particular TCS environmental sensing systems for this type of defense and illustrates the proof of principle that if these TCS were inhibited, the efficacy of certain antibiotics might be considerably enhanced.

scholarly journals Prevalence of Methicillin Resistant Staphylococcus Aureus In Khwaja Yunus Ali Medical College Hospital

KYAMC Journal ◽  
2017 ◽  
Vol 7 (1) ◽  
pp. 673-677
Author(s):  
Abdullah Akhtar Ahmed ◽  
Shakhaowat Hossain ◽  
Babul Aktar ◽  
Nusrat Akhtar Juyee ◽  
SM Ali Hasan
Keyword(s):  
Staphylococcus Aureus ◽  
Tract Infection ◽  
Respiratory Tract ◽  
Infection Control ◽  
Respiratory Tract Infection ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Throat Swab ◽  
College Hospital ◽  
Methicillin Resistant ◽  
Medical College

Background: Methicillin-resistant Staphylococcus aureus (MRSA) is a major cause of healthcare-associated infections. To combat the challenge of life threatening MRSA remains a primary focus of most hospital infection control programs6. This study is undertaken in Khwaja Yunus Ali Medical College Hospital to identify the MRSA for determination of its prevalence and is considered a component of an infection control program in many countries5.Methods: Three hundred seventy hospitalized patients of surgery and medicine departments were studied during 2015. Clinical information of the patients and their pus, wound swab, sputum, throat swab and CSF were cultured.Results: Out of 370 patients, pus and wound swab of 217 (59%) had wound infection, sputum and throat swab of 141 had respiratory tract infection (38%) and CSF of 12 (3.2%) had meningitis were aseptically collected and cultured. Staphylococcus aureus were isolated in 51% cases and out of them MRSA was identified in 72 (73%) cases. MRSA isolated in 50% cases of meningitis, 49% cases of respiratory tract infection and 29% cases of wound infection.Conclusion: Methicillin-resistant Staphylococcus aureus appeared as a common cause of major illness and death and impose serious economic costs on patients and hospitals of our area like other developing countries. Detection of MRSA was associated with more severe clinical presentation.KYAMC Journal Vol. 7, No.-1, Jul 2016, Page 673-677

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