scholarly journals Down‐regulation of long noncoding RNA PVT 1 inhibits esophageal carcinoma cell migration and invasion and promotes cell apoptosis via micro RNA ‐145‐mediated inhibition of FSCN 1

2019 ◽  
Vol 13 (12) ◽  
pp. 2554-2573 ◽  
Author(s):  
Si‐Ning Shen ◽  
Ke Li ◽  
Ying Liu ◽  
Cheng‐Liang Yang ◽  
Chun‐Yu He ◽  
...  
Keyword(s):  
Cell Migration ◽  
Esophageal Carcinoma ◽  
Cell Apoptosis ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Carcinoma Cell ◽  
Micro Rna ◽  
Migration And Invasion ◽  
Down Regulation ◽  
Cell Migration And Invasion

scholarly journals LINC00665 enhances tumorigenicity of endometrial carcinoma by interacting with high mobility group AT-hook 1  

2020 ◽  
Author(s):  
Yixuan Cai ◽  
Min Hao ◽  
Yue Chang ◽  
Yun Liu
Keyword(s):  
Cell Cycle ◽  
Cell Migration ◽  
Endometrial Carcinoma ◽  
Cell Apoptosis ◽  
Carcinoma Cell ◽  
Cell Counting ◽  
Migration And Invasion ◽  
Ki 67 ◽  
Cell Migration And Invasion ◽  
Endometrial Carcinoma Cell

Abstract Background: Endometrial carcinoma is a frequently diagnosed cancer among females. LncRNAs are reported to be associated with various cancers. Their biological roles in endometrial carcinoma progression is an emerging scientific area. LINC00665 can exert a significant role in many cancers. However, its potential function in endometrial carcinoma is still poorly known.Method: qRT-PCR was carried out to test expression of LINC00665 and HMGA1. Western blot analysis was carried out to detect protein expression of HMGA1. Cell proliferation was evaluated using Cell Counting Kit-8 (CCK-8) and EdU assay. Flow cytometry assay was used to determine cell apoptosis and cell cycle. Wound healing and transwell invasion assay was carried out to test cell migration and invasion. Immunohistochemical staining and HE staining were conducted to assess Ki-67 and tumor growth respectively.Results: Expression of LINC00665 in clinical endometrial carcinoma tissues and cells was obviously up-regulated. Loss of LINC00665 could repress endometrial carcinoma cell viability, induce cell apoptosis and block cell cycle in G1 phase. KLE and HHUA cell migration and invasion ability were depressed by LINC00665 shRNA. Decrease of LINC00665 suppressed endometrial carcinoma tumorigenicity in vivo. RIP assay proved that LINC00665 directly bound with HMGA1 protein. shRNA of HMGA1 obviously restrained endometrial carcinoma cell growth and cell invasion.Conclusions: LINC00665 might promote endometrial carcinoma progression by positively modulating HMGA1.

scholarly journals The histone demethylase JMJD1A induces cell migration and invasion by up-regulating the expression of the long noncoding RNA MALAT1

Oncotarget ◽  
2014 ◽  
Vol 5 (7) ◽  
pp. 1793-1804 ◽  
Author(s):  
Andrew E. Tee ◽  
Dora Ling ◽  
Charlotte Nelson ◽  
Bernard Atmadibrata ◽  
Marcel E. Dinger ◽  
...  
Keyword(s):  
Cell Migration ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Histone Demethylase ◽  
Migration And Invasion ◽  
Cell Migration And Invasion
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