Understanding the Recognition of Transfer RNAs by Aminoacyl Transfer RNA Synthetases

2006 ◽  
pp. 187-222 ◽  
Author(s):  
Paul R. Schimmel
Keyword(s):  
Transfer Rna ◽  
Transfer Rnas ◽  
Aminoacyl Transfer

Effect of aminoacyl transfer RNA synthetases on H-5 exchange of specific pyrimidines in transfer RNAs

Biochemistry ◽  
1977 ◽  
Vol 16 (25) ◽  
pp. 5454-5460 ◽  
Author(s):  
Hubert J. P. Schoemaker ◽  
Paul R. Schimmel
Keyword(s):  
Transfer Rna ◽  
Transfer Rnas ◽  
Aminoacyl Transfer

Oligoribonucleotide synthesis. IX. Synthesis of sequences corresponding to the dihydrouridine loop neck region common in several transfer RNA molecules

1976 ◽  
Vol 54 (11) ◽  
pp. 1714-1721 ◽  
Author(s):  
T. E. England ◽  
Thomas Neilson
Keyword(s):  
Neck Region ◽  
Transfer Rna ◽  
Coupling Reactions ◽  
Special Significance ◽  
Transfer Rnas ◽  
Rna Molecules ◽  
Activating Agent ◽  
Phosphotriester Method

The syntheses of the oligoribonucleotides GpApGpC, GpCpUpC, and ApGpCpUpC by an improved phosphotriester method are described. These sequences are found in the double-stranded region adjacent to the dihydrouridine loop of several transfer RNAs. Of special significance is the improvement in yields that the activating agent, mesitylenesulfonyl triazolide, provides in coupling reactions involving purine residues.

scholarly journals The effect of hypermethylation on the functional properties of transfer ribonucleic acid. Formation of aminoacyl-transfer-ribonucleic acid

1969 ◽  
Vol 114 (2) ◽  
pp. 429-435 ◽  
Author(s):  
David J. Pillinger ◽  
John Hay ◽  
Ernest Borek
Keyword(s):  
Amino Acids ◽  
Ribonucleic Acid ◽  
Control Sample ◽  
Transfer Rna ◽  
E Coli ◽  
Functional Sites ◽  
The Individual ◽  
Almost All ◽  
Aminoacyl Transfer ◽  
Kinetics Of

1. The ability of chemically hypermethylated Escherichia coli B transfer RNA to accept 19 amino acids was studied and the results were compared with those obtained with a control sample of E. coli B transfer RNA incubated under similar conditions in the absence of methylating agent. 2. There is a marked decrease in the ability of the modified transfer RNA to accept amino acids in almost all instances. 3. The acceptance of cysteine appears to be unique in that it is enhanced in the hypermethylated transfer RNA. 4. More detailed studies on the kinetics of acceptance for six amino acids is presented, emphasizing the variation in response of the individual amino acids. 5. Increasing hypermethylation causes a progressive decrease in the amino acid acceptance. 6. The results are discussed in terms of methylation at functional sites within the transfer RNA and possible conformational alterations to the structure of the macromolecule.

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