Background. Teicoplanin and vancomycin are glycopeptide antibiotics currently
in use for treatment of multidrug-resistant bacterial infections. Scope and
Approach. Severe undesirable effects, such as ototoxicity, nephrotoxicity and
neutropenia have been reported for vancomycin and teicoplanin, which
necessitates monitoring the concentration of these two drugs in different
biological samples. In order to obtain precise and accurate results,
sensitive, reliable and fast methods are necessary. The main aim of this mini
review is to give a clear and concise overview of the recently developed,
validated, novel and improved methods for glycopeptide antibiotic analyses in
various biological matrices. Also, the variability of the matrices requires
optimal and effective sample preparation procedures to be developed, and so
these are discussed. Key Findings and Conclusions. Different liquid
chromatography-tandem mass spectrometry (LC-MS/MS) methods have been
described for quantitative determination of glycopeptide antibiotics in
various biological matrices. It was shown that protein precipitation was a
convenient method for sample preparation despite the high number of novel
sample preparation methods.
Inhibition of feline (FIPV) and human (SARS) coronavirus by semisynthetic derivatives of glycopeptide antibiotics
