Some 2-substitution derivatives of 5-(4-oxo-6-hydroxy-3,4-dihydro-5-pyrimidinyl)pentanoic acid

1983 ◽  
Vol 48 (1) ◽  
pp. 304-311 ◽  
Author(s):  
Jiří Křepelka ◽  
Jan Beneš ◽  
Vladimír Pouzar ◽  
Jaroslav Vachek ◽  
Jiří Holubek
Keyword(s):  
Nitrile Group ◽  
Antineoplastic Activity ◽  
Carboxyl Group ◽  
Positional Isomers ◽  
Pentanoic Acid ◽  
Pharmacological Tests ◽  
Derivatives Of

Condensation of triethyl ester of 1,1,5-pentanetricarboxylic acid (XI) with substituted guanidines XXII - XXIX gave acids II - IX, which were converted into esters XI - XIX. The acid II and the ester XI were obtained as mixtures of positional isomers. Analogously, condensation of the triester XXI with dicyanodiamide gave rise to acid X, whose nitrile group, under conditions of esterification of a carboxyl group, produced iminoether XX. In pharmacological tests for antineoplastic activity the compounds prepared exhibited weaker efficacy than 5-(2-amino-6-hydroxy-4-oxo-3,4-dihydro-5-pyrimidinyl)pentanoic acid (I), employed as standard.

Fused bicyclic heteroarylpiperazine-substituted l-prolylthiazolidines as highly potent DPP-4 inhibitors lacking the electrophilic nitrile group

2012 ◽  
Vol 20 (16) ◽  
pp. 5033-5041 ◽  
Author(s):  
Tomohiro Yoshida ◽  
Fumihiko Akahoshi ◽  
Hiroshi Sakashita ◽  
Shuji Sonda ◽  
Masahiro Takeuchi ◽  
...  
Keyword(s):  
Nitrile Group

Study on Crosslinking in Diimide Reduction of Nitrile Butadiene Rubber

2006 ◽  
Vol 79 (4) ◽  
pp. 602-609
Author(s):  
Shuqin Zhou ◽  
Shaoyi Li ◽  
Huadong Bai
Keyword(s):  
Hydrogen Peroxide ◽  
Reaction Time ◽  
Boric Acid ◽  
Esr Spectroscopy ◽  
Redox System ◽  
Nitrile Group ◽  
Crosslinking Reaction ◽  
Butadiene Rubber ◽  
Drying Process ◽  
Spectroscopy Analysis

Abstract Acrylonitrile-butadiene rubber (NBR) in latex form was selectively hydrogenated by redox system consisting of hydrazine hydrate and hydrogen peroxide, with boric acid as catalyst. Soluble hydrogenated NBR latex was obtained; but the coagulated products were gelled on drying. This problem becomes the major obstacle for the hydrogenation technique to be commercialized. It is important to study the crosslinking reaction in the system and to solve the problem. The cause for the crosslink was investigated in three possibilities: (i) crosslinking caused by the hydrogenation of CN group; (ii) by the oxidation of C=C double bonds and (iii) by radicals in the system. The control of the crosslink was also studied. The oil resistant nitrile group —CN on the polymer chain had no change during drying process. There were no signs of carbonyl group C=O formed by oxidation and amine like groups -NH- formed by the hydrogenation of CN in HNBR gel fraction. The newly formed alkoxyl radicals were detected by ESR spectroscopy analysis in the hydrogenation system after specific reaction time. Crosslinking reaction was controlled to a large extent by using hydroquinone as gel inhibitor.

scholarly journals Highly selective electrochemical fluorination of dithioacetal derivatives bearing electron-withdrawing substituents at the position α to the sulfur atom using poly(HF) salts

2015 ◽  
Vol 11 ◽  
pp. 85-91 ◽  
Author(s):  
Bin Yin ◽  
Shinsuke Inagi ◽  
Toshio Fuchigami
Keyword(s):  
Sulfur Atom ◽  
Nitrile Group ◽  
Amide Group ◽  
Sharp Contrast ◽  
Product Selectivity ◽  
Electrochemical Fluorination ◽  
Weak Electron ◽  
Electron Withdrawing Substituents

Anodic fluorination of dithioacetals bearing electron-withdrawing ester, acetyl, amide, and nitrile groups at their α-positions was comparatively studied using various supporting poly(HF) salts like Et3N·nHF (n = 3–5) and Et4NF·nHF (n = 3–5). In the former two cases, the corresponding α-fluorination products or fluorodesulfurization products were obtained selectively depending on supporting poly(HF) salts used. In sharp contrast, in the latter two cases, fluorination product selectivity was strongly affected by the electron-withdrawing ability of α-substituents: A dithioacetal bearing a relatively weak electron-withdrawing amide group provided a fluorodesulfurization product selectively while a dithioacetal having a strongly electron-withdrawing nitrile group gave the α-fluorination product predominantly regardless of the poly(HF) salts used.

Calorimetric Study of Nitrile Group−Solvent Interactions and Comparison with Dispersive Quasi-Chemical (DISQUAC) Predictions†

2010 ◽  
Vol 55 (12) ◽  
pp. 5406-5412 ◽  
Author(s):  
Bruno Marongiu ◽  
Silvia Porcedda ◽  
Michela Marrocu ◽  
Danilo Falconieri ◽  
Alessandra Piras
Keyword(s):  
Nitrile Group ◽  
Calorimetric Study ◽  
Solvent Interactions

scholarly journals Crystal structures of 4-chloropyridine-2-carbonitrile and 6-chloropyridine-2-carbonitrile exhibit different intermolecular π-stacking, C—H...Nnitrileand C—H...Npyridineinteractions

2015 ◽  
Vol 71 (7) ◽  
pp. 852-856 ◽  
Author(s):  
Matthew J. Montgomery ◽  
Thomas J. O'Connor ◽  
Joseph M. Tanski
Keyword(s):  
Solid State ◽  
Crystal Structures ◽  
Pyridine Ring ◽  
Nitrile Group ◽  
Two Dimensional ◽  
One Dimensional ◽  
Face To Face ◽  
Π Stacking

The two title compounds are isomers of C6H3ClN2containing a pyridine ring, a nitrile group, and a chloro substituent. The molecules of each compound pack together in the solid state with offset face-to-face π-stacking, and intermolecular C—H...Nnitrileand C—H...Npyridineinteractions. 4-Chloropyridine-2-carbonitrile, (I), exhibits pairwise centrosymmetric head-to-head C—H...Nnitrileand C—H...Npyridineinteractions, forming one-dimensional chains, which are π-stacked in an offset face-to-face fashion. The intermolecular packing of the isomeric 6-chloropyridine-2-carbonitrile, (II), which differs only in the position of the chloro substituent on the pyridine ring, exhibits head-to-tail C—H...Nnitrileand C—H...Npyridineinteractions, forming two-dimensional sheets which are π-stacked in an offset face-to-face fashion. In contrast to (I), the offset face-to-face π-stacking in (II) is formed between molecules with alternating orientations of the chloro and nitrile substituents.

Sulfur‐Assisted Deprotection of Methylene Nitrile Group: One‐Pot Synthesis of 4‐Substituted‐2 H ‐1,2,3‐triazoles

2018 ◽  
Vol 3 (26) ◽  
pp. 7565-7571 ◽  
Author(s):  
Hunsur Nagendra Nagesh ◽  
Srinivasarao Singireddi ◽  
Amaroju Suresh ◽  
Shashidhar Nizalapur ◽  
Sankaranarayanan Murugesan ◽  
...  
Keyword(s):  
Nitrile Group ◽  
One Pot ◽  
One Pot Synthesis

scholarly journals An overview of synthetic modification of nitrile group in polymers and applications

2020 ◽  
Vol 58 (8) ◽  
pp. 1039-1061 ◽  
Author(s):  
Pambingal Rajan Sruthi ◽  
Saithalavi Anas
Keyword(s):  
Nitrile Group
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