scholarly journals Synthesis of Size-Tunable Polymeric Nanoparticles Enabled by 3D Hydrodynamic Flow Focusing in Single-Layer Microchannels

2011 ◽  
Vol 23 (12) ◽  
pp. H79-H83 ◽  
Author(s):  
Minsoung Rhee ◽  
Pedro M. Valencia ◽  
Maria I. Rodriguez ◽  
Robert Langer ◽  
Omid C. Farokhzad ◽  
...  
Keyword(s):  
Polymeric Nanoparticles ◽  
Single Layer ◽  
Hydrodynamic Flow ◽  
Flow Focusing

MICROFLUIDICS: Synthesis of Size-Tunable Polymeric Nanoparticles Enabled by 3D Hydrodynamic Flow Focusing in Single-Layer Microchannels (Adv. Mater. 12/2011)

2011 ◽  
Vol 23 (12) ◽  
pp. H78-H78 ◽  
Author(s):  
Minsoung Rhee ◽  
Pedro M. Valencia ◽  
Maria I. Rodriguez ◽  
Robert Langer ◽  
Omid C. Farokhzad ◽  
...  
Keyword(s):  
Polymeric Nanoparticles ◽  
Single Layer ◽  
Hydrodynamic Flow ◽  
Flow Focusing

scholarly journals A 3D hydrodynamic flow-focusing device for cell sorting

2021 ◽  
Vol 25 (3) ◽  
Author(s):  
Xiaofei Yuan ◽  
Andrew Glidle ◽  
Hitoshi Furusho ◽  
Huabing Yin
Keyword(s):  
Cell Sorting ◽  
Control Strategies ◽  
Three Dimensional ◽  
Hydrodynamic Flow ◽  
Proof Of Concept ◽  
Flow Focusing ◽  
Hydrodynamic Focusing ◽  
Cell Handling ◽  
Fluid Flow Control ◽  
High Degree

AbstractOptical-based microfluidic cell sorting has become increasingly attractive for applications in life and environmental sciences due to its ability of sophisticated cell handling in flow. The majority of these microfluidic cell sorting devices employ two-dimensional fluid flow control strategies, which lack the ability to manipulate the position of cells arbitrarily for precise optical detection, therefore resulting in reduced sorting accuracy and purity. Although three-dimensional (3D) hydrodynamic devices have better flow-focusing characteristics, most lack the flexibility to arbitrarily position the sample flow in each direction. Thus, there have been very few studies using 3D hydrodynamic flow focusing for sorting. Herein, we designed a 3D hydrodynamic focusing sorting platform based on independent sheath flow-focusing and pressure-actuated switching. This design offers many advantages in terms of reliable acquisition of weak Raman signals due to the ability to precisely control the speed and position of samples in 3D. With a proof-of-concept demonstration, we show this 3D hydrodynamic focusing-based sorting device has the potential to reach a high degree of accuracy for Raman activated sorting.

Design, characterization and application of a novel mono-layer pin-microvalve for microfluidic devices

RSC Advances ◽  
2014 ◽  
Vol 4 (46) ◽  
pp. 24394-24398 ◽  
Author(s):  
Mahyar Nasabi ◽  
Masoomeh Tehranirokh ◽  
Francisco Javier Tovar-Lopez ◽  
Abbas Kouzani ◽  
Khashayar Khoshmanesh ◽  
...  
Keyword(s):  
Microfluidic Devices ◽  
Hydrodynamic Flow ◽  
Flow Focusing ◽  
Mono Layer

We introduce a novel manual pin-valve which can operate in both analogue (partially close) and digital (on/off) states. We also demonstrate implementation of this pin-valve in a hydrodynamic flow focusing (HFF) device.

scholarly journals Patterning of cell-instructive hydrogels by hydrodynamic flow focusing

Lab on a Chip ◽  
2013 ◽  
Vol 13 (11) ◽  
pp. 2099 ◽  
Author(s):  
Steffen Cosson ◽  
Simone Allazetta ◽  
Matthias P. Lutolf
Keyword(s):  
Hydrodynamic Flow ◽  
Flow Focusing

Use of hydrodynamic flow focusing for the generation of biodegradable camptothecin‐loaded polymer microspheres

2008 ◽  
Vol 97 (11) ◽  
pp. 4943-4954 ◽  
Author(s):  
Thomas Schneider ◽  
Hong Zhao ◽  
John K. Jackson ◽  
Glenn H. Chapman ◽  
James Dykes ◽  
...  
Keyword(s):  
Hydrodynamic Flow ◽  
Polymer Microspheres ◽  
Flow Focusing

Controllable formation of aromatic nanoparticles in a three-dimensional hydrodynamic flow focusing microfluidic device

RSC Advances ◽  
2013 ◽  
Vol 3 (39) ◽  
pp. 17762 ◽  
Author(s):  
Liguo Jiang ◽  
Weiping Wang ◽  
Ying Chau ◽  
Shuhuai Yao
Keyword(s):  
Microfluidic Device ◽  
Three Dimensional ◽  
Hydrodynamic Flow ◽  
Flow Focusing

Two-dimensional hydrodynamic flow focusing in a microfluidic platform featuring a monolithic integrated glass micronozzle

2016 ◽  
Vol 109 (14) ◽  
pp. 144101 ◽  
Author(s):  
Yifan Liu ◽  
Yusheng Shen ◽  
Lian Duan ◽  
Levent Yobas
Keyword(s):  
Hydrodynamic Flow ◽  
Two Dimensional ◽  
Flow Focusing ◽  
Microfluidic Platform

scholarly journals MRBLES 2.0: High-throughput generation of chemically functionalized spectrally and magnetically-encoded hydrogel beads using a simple single-layer microfluidic device

2020 ◽  
Author(s):  
Yinnian Feng ◽  
Adam K. White ◽  
Jamin B. Hein ◽  
Eric A. Appel ◽  
Polly M. Fordyce
Keyword(s):  
Magnetic Nanoparticles ◽  
Functional Groups ◽  
High Throughput ◽  
Single Layer ◽  
Flow Focusing ◽  
Polymer Mixtures ◽  
Simple Method ◽  
Hydrogel Beads ◽  
Basic Biology ◽  
A Minor

AbstractWidespread adoption of bead-based multiplexed bioassays requires the ability to easily synthesize encoded microspheres and conjugate analytes of interest to their surface. Here, we present a simple method (MRBLEs 2.0) for efficient high-throughput generation of microspheres with ratiometric barcode lanthanide encoding (MRBLEs) bearing functional groups for downstream bioconjugation. Bead production in MRBLEs 2.0 relies on manual mixing of lanthanide/polymer mixtures (each of which comprises a unique spectral code) followed by droplet generation using single-layer, parallel flow-focusing devices and off-chip batch polymerization of droplets into beads. To streamline downstream analyte coupling, MRBLEs 2.0 crosslinks copolymers bearing functional groups on the bead surface simultaneously during bead generation. Using the MRBLEs 2.0 pipeline, we generate monodisperse MRBLEs containing 48 distinct well-resolved spectral codes in high-throughput (>150,000/min and can be boosted to 450,000/min). We further demonstrate the efficient conjugation of oligonucleotides and entire proteins to carboxyl MRBLEs and biotin to amino MRBLEs. Finally, we show that MRBLEs can also be magnetized via simultaneous incorporation of magnetic nanoparticles with only a minor decrease in the potential code space. We anticipate that MRBLEs 2.0 can be directly applied towards a wide variety of downstream assays from basic biology to diagnostics and other translational research.

Effects of chemical and physical parameters in the generation of microspheres by hydrodynamic flow focusing

2011 ◽  
Vol 87 (2) ◽  
pp. 361-368 ◽  
Author(s):  
Thomas Schneider ◽  
Glenn H. Chapman ◽  
Urs O. Häfeli
Keyword(s):  
Hydrodynamic Flow ◽  
Physical Parameters ◽  
Flow Focusing
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