Two-dimensional hydrodynamic flow focusing in a microfluidic platform featuring a monolithic integrated glass micronozzle

2016 ◽  
Vol 109 (14) ◽  
pp. 144101 ◽  
Author(s):  
Yifan Liu ◽  
Yusheng Shen ◽  
Lian Duan ◽  
Levent Yobas
Keyword(s):  
Hydrodynamic Flow ◽  
Two Dimensional ◽  
Flow Focusing ◽  
Microfluidic Platform

scholarly journals A 3D hydrodynamic flow-focusing device for cell sorting

2021 ◽  
Vol 25 (3) ◽  
Author(s):  
Xiaofei Yuan ◽  
Andrew Glidle ◽  
Hitoshi Furusho ◽  
Huabing Yin
Keyword(s):  
Cell Sorting ◽  
Control Strategies ◽  
Three Dimensional ◽  
Hydrodynamic Flow ◽  
Proof Of Concept ◽  
Flow Focusing ◽  
Hydrodynamic Focusing ◽  
Cell Handling ◽  
Fluid Flow Control ◽  
High Degree

AbstractOptical-based microfluidic cell sorting has become increasingly attractive for applications in life and environmental sciences due to its ability of sophisticated cell handling in flow. The majority of these microfluidic cell sorting devices employ two-dimensional fluid flow control strategies, which lack the ability to manipulate the position of cells arbitrarily for precise optical detection, therefore resulting in reduced sorting accuracy and purity. Although three-dimensional (3D) hydrodynamic devices have better flow-focusing characteristics, most lack the flexibility to arbitrarily position the sample flow in each direction. Thus, there have been very few studies using 3D hydrodynamic flow focusing for sorting. Herein, we designed a 3D hydrodynamic focusing sorting platform based on independent sheath flow-focusing and pressure-actuated switching. This design offers many advantages in terms of reliable acquisition of weak Raman signals due to the ability to precisely control the speed and position of samples in 3D. With a proof-of-concept demonstration, we show this 3D hydrodynamic focusing-based sorting device has the potential to reach a high degree of accuracy for Raman activated sorting.

scholarly journals Shrinking microbubbles with microfluidics: mathematical modelling to control microbubble sizes

2021 ◽  
Author(s):  
A. Salari ◽  
V. Gnyawali ◽  
I. M. Griffiths ◽  
R. Karshafian ◽  
Michael C. Kolios ◽  
...  
Keyword(s):  
Life Sciences ◽  
Microfluidic Channel ◽  
Flow Focusing ◽  
Bubble Generation ◽  
Microfluidic Platform ◽  
Interfacial Tensions ◽  
Precise Control ◽  
Ultrasound Diagnostics ◽  
Bubble Sizes ◽  
Good Agreement

Microbubbles have applications in industry and life-sciences. In medicine, small encapsulated bubbles (< 10 μm) are desirable because of their utility in drug/oxygen delivery, sonoporation, and ultrasound diagnostics. While there are various techniques for generating microbubbles, microfluidic methods are distinguished due to their precise control and ease-offabrication. Nevertheless, sub-10 μm diameter bubble generation using microfluidics remains challenging, and typically requires expensive equipment and cumbersome setups. Recently, our group reported a microfluidic platform that shrinks microbubbles to sub-10 μm diameters. The microfluidic platform utilizes a simple microbubble-generating flow-focusing geometry, integrated with a vacuum shrinkage system, to achieve microbubble sizes that are desirable in medicine, and pave the way to eventual clinical uptake of microfluidically generated microbubbles. A theoretical framework is now needed to relate the size of the microbubbles produced and the system’s input parameters. In this manuscript, we characterize microbubbles made with various lipid concentrations flowing in solutions that have different interfacial tensions, and monitor the changes in bubble size along the microfluidic channel under various vacuum pressures. We use the physics governing the shrinkage mechanism to develop a mathematical model that predicts the resulting bubble sizes and elucidates the dominant parameters controlling bubble sizes. The model shows a good agreement with the experimental data, predicting the resulting microbubble sizes under different experimental input conditions. We anticipate that the model will find utility in enabling users of the microfluidic platform to engineer bubbles of specific sizes.

Design, characterization and application of a novel mono-layer pin-microvalve for microfluidic devices

RSC Advances ◽  
2014 ◽  
Vol 4 (46) ◽  
pp. 24394-24398 ◽  
Author(s):  
Mahyar Nasabi ◽  
Masoomeh Tehranirokh ◽  
Francisco Javier Tovar-Lopez ◽  
Abbas Kouzani ◽  
Khashayar Khoshmanesh ◽  
...  
Keyword(s):  
Microfluidic Devices ◽  
Hydrodynamic Flow ◽  
Flow Focusing ◽  
Mono Layer

We introduce a novel manual pin-valve which can operate in both analogue (partially close) and digital (on/off) states. We also demonstrate implementation of this pin-valve in a hydrodynamic flow focusing (HFF) device.

A series solution of the boundary value problem arising in the application of fluid mechanics

2018 ◽  
Vol 28 (10) ◽  
pp. 2480-2490 ◽  
Author(s):  
Yasir Khan
Keyword(s):  
Differential Equation ◽  
Reynolds Number ◽  
Transverse Direction ◽  
Hydrodynamic Flow ◽  
Porous Channel ◽  
Second Grade ◽  
Two Dimensional ◽  
Second Grade Fluid ◽  
Content Type ◽  
Grade Fluid

Purpose This paper aims to study the two-dimensional steady magneto-hydrodynamic flow of a second-grade fluid in a porous channel using the homotopy perturbation method (HPM). Design/methodology/approach The governing Navier–Stokes equations of the flow are reduced to a third-order nonlinear ordinary differential equation by a suitable similarity transformation. Analytic solution of the resulting differential equation is obtained using the HPM. Mathematica software is used to visualize the flow behavior. The effects of the various parameters on velocity field are analyzed through appropriate graphs. Findings It is found that x component of the velocity increases with the increase of the Hartman number when the transverse direction variable ranges from 0 to 0.2 and the reverse behavior is observed when transverse direction variable takes values between 0.2 and 0.5. It is noted that the y component of the velocity increases rapidly with the increase of the transverse direction variable. The y component of the velocity increases marginally with the increase of the Hartman number M. The effect of the Reynolds number R on the x and y components of the velocity is quite opposite to the effect of the Hartman number on the x and y components of the velocity and the effect of the parameter on the x and y components of the velocity is similar to that of the Reynolds number. Originality/value To the best of the author’s knowledge, nobody had tried before two-dimensional steady magneto-hydrodynamic flow of a second-grade fluid in a porous channel using the HPM.

scholarly journals Patterning of cell-instructive hydrogels by hydrodynamic flow focusing

Lab on a Chip ◽  
2013 ◽  
Vol 13 (11) ◽  
pp. 2099 ◽  
Author(s):  
Steffen Cosson ◽  
Simone Allazetta ◽  
Matthias P. Lutolf
Keyword(s):  
Hydrodynamic Flow ◽  
Flow Focusing

Use of hydrodynamic flow focusing for the generation of biodegradable camptothecin‐loaded polymer microspheres

2008 ◽  
Vol 97 (11) ◽  
pp. 4943-4954 ◽  
Author(s):  
Thomas Schneider ◽  
Hong Zhao ◽  
John K. Jackson ◽  
Glenn H. Chapman ◽  
James Dykes ◽  
...  
Keyword(s):  
Hydrodynamic Flow ◽  
Polymer Microspheres ◽  
Flow Focusing

scholarly journals Synthesis of Size-Tunable Polymeric Nanoparticles Enabled by 3D Hydrodynamic Flow Focusing in Single-Layer Microchannels

2011 ◽  
Vol 23 (12) ◽  
pp. H79-H83 ◽  
Author(s):  
Minsoung Rhee ◽  
Pedro M. Valencia ◽  
Maria I. Rodriguez ◽  
Robert Langer ◽  
Omid C. Farokhzad ◽  
...  
Keyword(s):  
Polymeric Nanoparticles ◽  
Single Layer ◽  
Hydrodynamic Flow ◽  
Flow Focusing

Controllable formation of aromatic nanoparticles in a three-dimensional hydrodynamic flow focusing microfluidic device

RSC Advances ◽  
2013 ◽  
Vol 3 (39) ◽  
pp. 17762 ◽  
Author(s):  
Liguo Jiang ◽  
Weiping Wang ◽  
Ying Chau ◽  
Shuhuai Yao
Keyword(s):  
Microfluidic Device ◽  
Three Dimensional ◽  
Hydrodynamic Flow ◽  
Flow Focusing

Two dimensional liquid flow focusing

2020 ◽  
Vol 32 (4) ◽  
pp. 042104 ◽  
Keyword(s):  
Liquid Flow ◽  
Two Dimensional ◽  
Flow Focusing
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