scholarly journals Growing Trans‐Species Islets in Tumor Extract‐Remodeled Testicles

2019 ◽  
Vol 6 (6) ◽  
pp. 1801694
Author(s):  
Zhenzhen Wang ◽  
Xiaying Rui ◽  
Junni Qiu ◽  
Yiqing Yan ◽  
Jingjing Gan ◽  
...  
Keyword(s):  

2019 ◽  
Vol 6 (6) ◽  
pp. 1970036 ◽  
Author(s):  
Zhenzhen Wang ◽  
Xiaying Rui ◽  
Junni Qiu ◽  
Yiqing Yan ◽  
Jingjing Gan ◽  
...  


2019 ◽  
Author(s):  
Diana Zamora-Olivares ◽  
Tamer S. Kaoud ◽  
Lingyu Zeng ◽  
Mitchell Telles ◽  
Eric V. Anslyn ◽  
...  


1944 ◽  
Vol 80 (1) ◽  
pp. 19-29 ◽  
Author(s):  
Albert Claude

1. Rat tumor extracts, containing chiefly the cytoplasmic constituents of leukemic cells, were fractionated into three main portions, the different components separating in the centrifuge according to size. 2. Mitochondria were isolated by centrifugation at relatively low speed. Elementary composition of purified mitochondria was found to correspond to about 11.5 per cent nitrogen, 1.6 per cent phosphorus, and 27 per cent lipids. Phosphorus and nitrogen content of the lipid portion suggests that as much as 75 to 80 per cent of the lipids of mitochondria is represented by phospholipids. Tests for ribose nucleic acid were positive. 3. Microsomes were separated by means of centrifugation at 18,000 x g. A relation between the high phosphorus content of the microsomes and the marked basophilia of the cytoplasm of leukemic cells is suggested. 4. Phosphorus distribution in the tumor extract, and light absorption analysis of the third fraction, seem to demonstrate that nucleic acid was not present either in a free condition, or in the form of nucleoprotein of relatively low molecular weight. The nature of the results suggests that ribose nucleic acid occurs in the cytoplasm of leukemic cells only in association with formed elements of relatively large size, namely microsomes, and mitochondria.



1983 ◽  
Vol 130 (2) ◽  
pp. 403-403
Author(s):  
S. Miyazaki ◽  
T. Akiyoshi ◽  
M. Kawaguchi ◽  
F. Koba ◽  
S. Arinaga ◽  
...  


2009 ◽  
Vol 260 (1) ◽  
pp. 28-32 ◽  
Author(s):  
Abbas Azadmehr ◽  
Ali Akbar Pourfathollah ◽  
Zahra Amirghofran ◽  
Zuhair Mohammad Hassan ◽  
Seyed Mohammad Moazzeni


The Prostate ◽  
2003 ◽  
Vol 55 (4) ◽  
pp. 292-298 ◽  
Author(s):  
Shaobo Zhang ◽  
Guangyuan Zeng ◽  
David S. Wilkes ◽  
Gerry E. Reed ◽  
Ronald C. McGarry ◽  
...  




Author(s):  
Olivier schussler ◽  
pierre-emmanuel falcoz ◽  
Juan-Carlos Chachques ◽  
Marco Alifano ◽  
Yves lecarpentier

Currently, the clinical impact of cell therapy after a myocardial infarction (MI) is limited by low cell engraftment due to significant cell death, including apoptosis, in an infarcted, inflammatory, poor angiogenic environment, low cell retention and secondary migration. Cells interact with their environment through integrin mechanoreceptors that control their survival/apoptosis/differentiation/migration/proliferation. Optimizing these interactions may be a way of improving outcomes. The association of free cells with a 3D-scaffold may be a way to target their integrins. Collagen is the most abundant structural component of the extracellular matrix (ECM) and the best contractility levels are achieved with cellular preparations containing collagen, fibrin, or Matrigel (i.e. tumor extract). In the interactions between cells and ECM, 3 main proteins are recognised: collagen, laminin and RGD (Arg-Gly-Asp) peptide. The RGD plays a key role in heart development, after MI, and on cardiac cells. Cardiomyocytes secrete their own laminin on collagen. The collagen has a non-functional cryptic RGD and is thus suboptimal for interactions with associated cells. The use of a collagen functionalized with RGD may help to improve collagen biofunctionality. It may help in the delivery of paracrine cells, whether or not they are contractile, and in assisting tissue engineering a safe contractile tissue.



1975 ◽  
Vol 79 (6) ◽  
pp. 683-685
Author(s):  
M. F. Nikonova ◽  
I. N. Maiskii ◽  
T. A. Pokrovskaya


1981 ◽  
Vol 67 (3) ◽  
pp. 163-167 ◽  
Author(s):  
Maria Caterina Sirianni ◽  
Giuseppe Luzi ◽  
Claudio Iavarone ◽  
Marisa Papaluca ◽  
Massimo Fiorilli ◽  
...  

The direct leucocyte migration inhibition test in capillary tubes was used to test 10 patients with colonic adenocarcinoma against KCl soluble extracts of an allogenic colon cancer and an allogenic normal colon fragment. Inhibition was consistently found with the cancer extract but not with the normal tissue extract. None of the control group of patients affected by other tumors, intestinal and liver disorders showed a migration inhibition in response to the colonic tumor extract. Our findings strongly suggest the presence of a tumor-associated antigen in the cancer extract.



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