The 3111T/C polymorphism of the CLOCK gene confers a predisposition to a lifetime lower body weight in patients with anorexia nervosa and bulimia nervosa: A preliminary study

SummaryThe significance of a history of anorexia nervosa as regards the diagnosis and treatment outcome for bulimia is unclear. In a retrospective analysis of medical records of 59 inpatients with bulimia (DSM-III), variables related to personal and psychiatric family history did not reveal any differences in bulimics subtyped according to previous anorexia nervosa as defined in the criteria of Russell (1979). These anamnestic data support the results of studies indicating that no specific clinical and outcome variables are correlated with a history of anorexia nervosa in bulimia. The lower body weight and longer duration of bulimia found in bulimic inpatients with a history of anorexia nervosa, however, should be further examined.

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1544Baseline predictors of attrition in a randomised controlled trial of treatments for people with recurrent binge eating episodes associated to overweight or obesity

International Journal of Epidemiology ◽

10.1093/ije/dyab168.414 ◽

2021 ◽

Vol 50 (Supplement_1) ◽

Author(s):

Haider Mannan ◽

Phillipa Hay

Keyword(s):

Body Weight ◽

Eating Disorder ◽

Bulimia Nervosa ◽

Binge Eating ◽

Lower Body ◽

Treatment Attrition ◽

Lower Body Weight ◽

Lower Treatment ◽

Overweight Or Obesity

Abstract Purpose Understanding the high rate of treatment attrition in trials of people with eating disorders is important as it can compromise the quality of the trials. In clinical practice, it may also contribute to illness chronicity, relapse, and costs. Thus, we investigated factors associated with treatment attrition to a new manualised psychotherapy HAPIFED compared to CBT-E, for individuals with Bulimia Nervosa or Binge Eating Disorder comorbid with overweight or obesity. Methods In total, 98 participants were recruited with 50 randomised to HAPIFED and 48 to the control intervention CBT-E, all administered in groups of up to 10 participants. An investigator external to the site conducted the random allocation, which was concealed from the statistician involved in the analysis, and known only to the therapists until the finalization of the 12-month follow-up after the end of active treatment. Three scenarios in the timeline treatment of a total of 30 sessions were assessed: 33% or 60% or 75% of presence. Logistic regression analysis was performed to find the correlates of attrition. Results None of the six variables - frequency of binge eating episodes, purging, eating disorder symptom severity, weight, illness duration and mental health-related quality of life - significantly predicted attrition at 33%, but longer illness duration predicted lower treatment attrition at both 60% and 75% presence of the interventions. Also for 75% presence, lower body weight predicted lower treatment attrition. Conclusions Lower attrition due to late treatment completion was associated with longer binge eating illness length and a lower body weight. More research is needed to recognize factors that may interfere with engagement in treatments aiming to avoid early dropout. Keywords binge eating disorder, bulimia nervosa, cognitive therapy, obesity, patient dropout Trial registration US National Institutes of Health clinical trial registration number NCT02464345, date of registration 1 June 2015.

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The effect of lower body weight support on arterial wave reflection in healthy adults

Journal of the American Society of Hypertension ◽

10.1016/j.jash.2014.03.004 ◽

2014 ◽

Vol 8 (6) ◽

pp. 388-393 ◽

Cited By ~ 2

Author(s):

Atif Afzal ◽

Daniel Fung ◽

Sean Galligan ◽

Ellen M. Godwin ◽

John G. Kral ◽

...

Keyword(s):

Body Weight ◽

Wave Reflection ◽

Healthy Adults ◽

Body Weight Support ◽

Lower Body ◽

Weight Support ◽

Lower Body Weight ◽

Arterial Wave Reflection

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Fryl deficiency is associated with defective kidney development and function in mice

Experimental Biology and Medicine ◽

10.1177/1535370218758249 ◽

2018 ◽

Vol 243 (5) ◽

pp. 408-417 ◽

Cited By ~ 3

Author(s):

Yong-Sub Byun ◽

Eun-Kyoung Kim ◽

Kimi Araki ◽

Ken-ichi Yamamura ◽

Kihoon Lee ◽

...

Keyword(s):

Body Weight ◽

Growth Retardation ◽

Normal Development ◽

Full Term ◽

Lower Body ◽

Mouse Line ◽

Lower Body Weight ◽

Gene Functions ◽

Convoluted Tubules

FRY like transcription coactivator ( Fryl) gene located on chromosome 5 is a paralog of FRY microtubule binding protein ( Fry) in vertebrates. It encodes a protein with unknown functions. Fryl gene is conserved in various species ranging from eukaryotes to human. Although there are several reports on functions of Fry gene, functions of Fryl gene remain unclear. A mouse line containing null mutation in Fryl gene by gene trapping was produced in this study for the first time. The survival and growth of Fryl−/− mice were observed. Fryl gene expression levels in mouse tissues were determined and histopathologic analyses were conducted. Most Fryl−/− mice died soon after birth. Rare Fryl−/− survivors showed growth retardation with significantly lower body weight compared to their littermate controls. Although they could breed, more than half of Fryl−/− survivors died of hydronephrosis before age 1. No abnormal histopathologic lesion was apparent in full-term embryo or adult tissues except the kidney. Abnormal lining cell layer detachments from walls of collecting and convoluted tubules in kidneys were apparent in Fryl−/− neonates and full-term embryos. Fryl gene was expressed in renal tubular tissues including the glomeruli and convoluted and collecting tubules. This indicates that defects in tubular systems are associated with Fryl functions and death of Fryl−/− neonates. Fryl protein is required for normal development and functional maintenance of kidney in mice. This is the first report of in vivo Fryl gene functions. Impact statement FRY like transcription coactivator ( Fryl) gene is conserved in various species ranging from eukaryotes to human. It expresses a protein with unknown function. We generated a Fryl gene mutant mouse line and found that most homozygous mice died soon after their birth. Rare Fryl−/− survivors showed growth retardation with significantly lower body weight compared to their littermate controls. Although they could breed, more than half of Fryl−/− survivors died of hydronephrosis before age 1. Full-term mutant embryos showed abnormal collecting and convoluted tubules in kidneys where Fryl gene was expressed. Collectively, these results indicate that Fryl protein is required for normal development and functional maintenance of kidney in mice. To the best of our knowledge, this is the first report on in vivo Fryl gene functions.

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Population Pharmacokinetic Analysis of Linezolid in Patients With Infectious Disease: Application to Lower Body Weight and Elderly Patients

The Journal of Clinical Pharmacology ◽

10.1177/0091270009337947 ◽

2009 ◽

Vol 49 (9) ◽

pp. 1071-1078 ◽

Cited By ~ 58

Author(s):

Sadahiro Abe ◽

Koji Chiba ◽

Brenda Cirincione ◽

Thaddeus H. Grasela ◽

Kaori Ito ◽

...

Keyword(s):

Infectious Disease ◽

Body Weight ◽

Elderly Patients ◽

Population Pharmacokinetic Analysis ◽

Pharmacokinetic Analysis ◽

Population Pharmacokinetic ◽

Lower Body ◽

Lower Body Weight

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Prevalence and predictors of postoperative peritoneal dialysis in infants

Asian Cardiovascular and Thoracic Annals ◽

10.1177/0218492320947543 ◽

2020 ◽

Vol 28 (8) ◽

pp. 476-481

Author(s):

Michael Caesario ◽

Dicky Fakhri ◽

Pribadi Wiranda Busro ◽

Salomo Purba ◽

Liza Fitria ◽

...

Keyword(s):

Body Weight ◽

Peritoneal Dialysis ◽

Cardiopulmonary Bypass ◽

Risk Adjustment ◽

Heart Surgery ◽

Congenital Heart Surgery ◽

Lower Body ◽

Cardiopulmonary Bypass Time ◽

Lower Body Weight ◽

Younger Age

Background Data regarding predictors of the eventual need for postoperative peritoneal dialysis in infants undergoing open heart surgery is still limited. We aimed to determine whether prolonged cardiopulmonary bypass time, surgical complexity classified according to Risk Adjustment for Congenital Heart Surgery category, younger age, and lower body weight increase the probability of requiring postoperative peritoneal dialysis. Methods We retrospectively analyzed data of 181 infants who underwent open heart surgery at our institution from January 1 to December 31, 2018. Cardiopulmonary bypass time, Risk Adjustment for Congenital Heart Surgery category, age, body weight, and the need for postoperative peritoneal dialysis were recorded and analyzed. Results Thirteen (7.2%) of the 181 patients required postoperative peritoneal dialysis. This group was found to have a longer cardiopulmonary bypass time, younger age, and lower body weight. Longer cardiopulmonary bypass time ( p = 0.001), higher Risk Adjustment for Congenital Heart Surgery category ( p = 0.018), younger age ( p < 0.001), and lower body weight ( p < 0.001) significantly increased the risk of postoperative peritoneal dialysis. Conclusion Longer cardiopulmonary bypass time, more complex surgery, younger age, and lower body weight increase the probability of requiring postoperative peritoneal dialysis in infants undergoing open heart surgery.

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