scholarly journals Impact of sex and APOE E4 on age‐related cerebral blood flow trajectories in cognitively asymptomatic middle‐aged and older adults: A longitudinal study

2020 ◽  
Vol 16 (S5) ◽  
Author(s):  
Rui Wang ◽  
Jennifer M. Oh ◽  
Alice Motovylyak ◽  
Yue Ma ◽  
Mark A. Sager ◽  
...  
Keyword(s):  
Older Adults ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Longitudinal Study ◽  
Middle Aged ◽  
Age Related

GREATER AORTIC STIFFNESS IS ASSOCIATED WITH LOWER HIPPOCAMPAL CEREBROVASCULAR RESERVE BUT NOT CEREBRAL BLOOD FLOW OR AMYLOID IN MIDDLE-AGED AND OLDER ADULTS

2018 ◽  
Vol 24 (C) ◽  
pp. 63
Author(s):  
Lyndsey E. DuBose ◽  
Laura L. Boles Ponto ◽  
David J. Moser ◽  
Gary L. Pierce
Keyword(s):  
Older Adults ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Aortic Stiffness ◽  
Middle Aged ◽  
Cerebrovascular Reserve

Aging and Recognition Memory: Changes in Regional Cerebral Blood Flow Associated with Components of Reaction Time Distributions

1999 ◽  
Vol 11 (5) ◽  
pp. 511-520 ◽  
Author(s):  
David J. Madden ◽  
Lawrence R. Gottlob ◽  
Laura L. Denny ◽  
Timothy G. Turkington ◽  
James M. Provenzale ◽  
...  
Keyword(s):  
Older Adults ◽  
Blood Flow ◽  
Young Adults ◽  
Cerebral Blood Flow ◽  
Reaction Time ◽  
Task Performance ◽  
Regional Cerebral Blood Flow ◽  
Regional Cerebral Blood ◽  
Age Related ◽  
The Mean

We used H215O positron emission tomography (PET) to measure age-related changes in regional cerebral blood flow (rCBF) during a verbal recognition memory task. Twelve young adults (20 to 29 years) and 12 older adults (62 to 79 years) participated. Separate PET scans were conducted during Encoding, Baseline, and Retrieval conditions. Each of the conditions involved viewing a series of 64 words and making a two-choice response manually. The complete reaction time (RT) distributions in each task condition were characterized in terms of an ex-Gaussian model (convolution of exponential and Gaussian functions). Parameter estimates were obtained for the mean of the exponential component (τ), representing a task-specific decision process and the mean of the Gaussian component (μ), representing residual sensory coding and response processes. Independently of age group, both μ and τ were higher in the Encoding and Retrieval conditions than in the Baseline condition, and τ was higher during Retrieval than during Encoding. Age-related slowing in task performance was evident primarily in μ. For young adults, rCBF activation in the right prefrontal cortex, in the Retrieval condition, was correlated positively with μ but not with τ. For older adults, rCBF changes (both increases and decreases) in several cortical regions were correlated with both μ and τ. The data suggest that the attentional demands of this task are relatively greater for older adults and consequently lead to the recruitment of additional neural systems during task performance.

scholarly journals Age-Related Difference in Weight Change and All-Cause Mortality in Middle-Aged and Older Korean Populations: Korean Longitudinal Study of Aging

2021 ◽  
Vol 42 (4) ◽  
pp. 297-302
Author(s):  
Jungki Suh ◽  
Yoon Jeong Cho ◽  
Hyun Ji Kim ◽  
Seong Soo Choi
Keyword(s):  
Older Adults ◽  
Weight Loss ◽  
Weight Gain ◽  
Longitudinal Study ◽  
Weight Change ◽  
Significant Risk ◽  
Middle Aged ◽  
Weight Losses ◽  
Age Related ◽  
All Cause Mortality

Background: Obesity is associated with increased mortality as a significant risk factor for chronic diseases, including cardiovascular diseases and cancer. Several people believe that weight gain is harmful, and weight loss helps maintain health. However, some studies have shown that weight loss, particularly among older adults, is more likely to increase the risk of mortality than weight gain.Methods: We used data for the cohort of the Korean Longitudinal Study of Aging, which is a nationwide stratified multi-stage sample of adults aged 45 years. The all-cause mortality risk was assessed using the survival status and the number of months of survival calculated from 2006 (baseline year) to 2016. Cox proportional hazard regression were used to study the causal link between weight change and all-cause mortality risk.Results: The results showed interactive associations between weight loss and mortality among middle-aged and older adults. The hazard ratio was 1.62 (95% confidence interval [CI], 1.10–2.40) for the participants aged 45–65 years with weight losses greater than 5 kg and 1.56 (95% CI, 1.29–1.89) for those older than 65 years with weight losses greater than 5 kg. The results for the group with weight gain above 5 kg were not significant. Middle-aged and older men showed an increase in all-cause mortality associated with weight loss of more than 5 kg, but only the older women showed significant results.Conclusion: This large-scale cohort study in Korea showed a relationship between weight loss and all-cause mortality in middle-aged and older individuals.

Lactotripeptide ingestion increases cerebral blood flow velocity in middle-aged and older adults

2018 ◽  
Vol 53 ◽  
pp. 61-66 ◽  
Author(s):  
Nobuhiko Akazawa ◽  
Ai Hamasaki ◽  
Koichiro Tanahashi ◽  
Keisei Kosaki ◽  
Toru Yoshikawa ◽  
...  
Keyword(s):  
Older Adults ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Flow Velocity ◽  
Blood Flow Velocity ◽  
Cerebral Blood Flow Velocity ◽  
Middle Aged

scholarly journals Age related cognitive decline: a clinical entity? A longitudinal study of cerebral blood flow and memory performance.

1997 ◽  
Vol 62 (6) ◽  
pp. 601-608 ◽  
Author(s):  
P Celsis ◽  
A Agniel ◽  
D Cardebat ◽  
J F Demonet ◽  
P J Ousset ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Longitudinal Study ◽  
Cognitive Decline ◽  
Memory Performance ◽  
Clinical Entity ◽  
Age Related ◽  
Age Related Cognitive Decline

scholarly journals Longitudinal changes in regional cerebral blood flow in late middle‐aged and older adults with treated and untreated obstructive sleep apnea

2021 ◽  
Author(s):  
Francis L'Heureux ◽  
Andrée‐Ann Baril ◽  
Katia Gagnon ◽  
Jean‐Paul Soucy ◽  
Chantal Lafond ◽  
...  
Keyword(s):  
Older Adults ◽  
Blood Flow ◽  
Obstructive Sleep Apnea ◽  
Cerebral Blood Flow ◽  
Sleep Apnea ◽  
Regional Cerebral Blood Flow ◽  
Regional Cerebral Blood ◽  
Middle Aged ◽  
Longitudinal Changes ◽  
Obstructive Sleep

scholarly journals Higher Aortic Stiffness Is Related to Lower Cerebral Blood Flow and Preserved Cerebrovascular Reactivity in Older Adults

Circulation ◽  
2018 ◽  
Vol 138 (18) ◽  
pp. 1951-1962 ◽  
Author(s):  
Angela L. Jefferson ◽  
Francis E. Cambronero ◽  
Dandan Liu ◽  
Elizabeth E. Moore ◽  
Jacquelyn E. Neal ◽  
...  
Keyword(s):  
Older Adults ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Aortic Stiffness ◽  
Cerebrovascular Reactivity

scholarly journals Sex-differences in age-related grip strength decline: A 10-year longitudinal study of community-living middle-aged and older Japanese

2016 ◽  
Vol 5 (1) ◽  
pp. 87-94 ◽  
Author(s):  
Rumi Kozakai ◽  
Fujiko Ando ◽  
Heung Youl Kim ◽  
Atsumu Yuki ◽  
Rei Otsuka ◽  
...  
Keyword(s):  
Sex Differences ◽  
Longitudinal Study ◽  
Grip Strength ◽  
Community Living ◽  
Middle Aged ◽  
Age Related
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