scholarly journals Sex-differences in age-related grip strength decline: A 10-year longitudinal study of community-living middle-aged and older Japanese

2016 ◽  
Vol 5 (1) ◽  
pp. 87-94 ◽  
Author(s):  
Rumi Kozakai ◽  
Fujiko Ando ◽  
Heung Youl Kim ◽  
Atsumu Yuki ◽  
Rei Otsuka ◽  
...  
Keyword(s):  
Sex Differences ◽  
Longitudinal Study ◽  
Grip Strength ◽  
Community Living ◽  
Middle Aged ◽  
Age Related

Age-Related Changes in Physical Fitness Among Community-Living Middle-Aged and Older Japanese: A 12-Year Longitudinal Study

2020 ◽  
Vol 91 (4) ◽  
pp. 662-675
Author(s):  
Rumi Kozakai ◽  
Yukiko Nishita ◽  
Rei Otsuka ◽  
Fujiko Ando ◽  
Hiroshi Shimokata
Keyword(s):  
Longitudinal Study ◽  
Physical Fitness ◽  
Community Living ◽  
Middle Aged ◽  
Age Related ◽  
Age Related Changes

scholarly journals Sex Differences in the Limit to Deficit Accumulation in Late Middle-Aged and Older Chinese People: Results From the Beijing Longitudinal Study of Aging

2013 ◽  
Vol 69 (6) ◽  
pp. 702-709 ◽  
Author(s):  
J. Shi ◽  
Z. Yang ◽  
X. Song ◽  
P. Yu ◽  
X. Fang ◽  
...  
Keyword(s):  
Sex Differences ◽  
Longitudinal Study ◽  
Chinese People ◽  
Middle Aged ◽  
Deficit Accumulation ◽  
Older Chinese

scholarly journals Impact of sex and APOE E4 on age‐related cerebral blood flow trajectories in cognitively asymptomatic middle‐aged and older adults: A longitudinal study

2020 ◽  
Vol 16 (S5) ◽  
Author(s):  
Rui Wang ◽  
Jennifer M. Oh ◽  
Alice Motovylyak ◽  
Yue Ma ◽  
Mark A. Sager ◽  
...  
Keyword(s):  
Older Adults ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Longitudinal Study ◽  
Middle Aged ◽  
Age Related

scholarly journals Age-Related Difference in Weight Change and All-Cause Mortality in Middle-Aged and Older Korean Populations: Korean Longitudinal Study of Aging

2021 ◽  
Vol 42 (4) ◽  
pp. 297-302
Author(s):  
Jungki Suh ◽  
Yoon Jeong Cho ◽  
Hyun Ji Kim ◽  
Seong Soo Choi
Keyword(s):  
Older Adults ◽  
Weight Loss ◽  
Weight Gain ◽  
Longitudinal Study ◽  
Weight Change ◽  
Significant Risk ◽  
Middle Aged ◽  
Weight Losses ◽  
Age Related ◽  
All Cause Mortality

Background: Obesity is associated with increased mortality as a significant risk factor for chronic diseases, including cardiovascular diseases and cancer. Several people believe that weight gain is harmful, and weight loss helps maintain health. However, some studies have shown that weight loss, particularly among older adults, is more likely to increase the risk of mortality than weight gain.Methods: We used data for the cohort of the Korean Longitudinal Study of Aging, which is a nationwide stratified multi-stage sample of adults aged 45 years. The all-cause mortality risk was assessed using the survival status and the number of months of survival calculated from 2006 (baseline year) to 2016. Cox proportional hazard regression were used to study the causal link between weight change and all-cause mortality risk.Results: The results showed interactive associations between weight loss and mortality among middle-aged and older adults. The hazard ratio was 1.62 (95% confidence interval [CI], 1.10–2.40) for the participants aged 45–65 years with weight losses greater than 5 kg and 1.56 (95% CI, 1.29–1.89) for those older than 65 years with weight losses greater than 5 kg. The results for the group with weight gain above 5 kg were not significant. Middle-aged and older men showed an increase in all-cause mortality associated with weight loss of more than 5 kg, but only the older women showed significant results.Conclusion: This large-scale cohort study in Korea showed a relationship between weight loss and all-cause mortality in middle-aged and older individuals.

A Longitudinal Study on the Changing Factors of Life Satisfaction of the Middle-aged

2018 ◽  
Vol 9 (4) ◽  
pp. 783-796
Author(s):  
Jinsook Lee ◽  
Wonseok Choi
Keyword(s):  
Life Satisfaction ◽  
Longitudinal Study ◽  
Middle Aged

scholarly journals A Prospective Study on the Association Between Grip Strength and Cognitive Function Among Middle-Aged and Elderly Chinese Participants

2019 ◽  
Vol 11 ◽  
Author(s):  
Yong Liu ◽  
Xinyi Cao ◽  
Nannan Gu ◽  
Bixi Yang ◽  
Jijun Wang ◽  
...  
Keyword(s):  
Cognitive Function ◽  
Prospective Study ◽  
Grip Strength ◽  
Middle Aged ◽  
Elderly Chinese ◽  
A Prospective Study

scholarly journals Inflamm-Aging Is Associated with Lower Plasma PTX3 Concentrations and an Impaired Capacity of PBMCs to Express hTERT following LPS Stimulation

2019 ◽  
Vol 2019 ◽  
pp. 1-13 ◽  
Author(s):  
Aaron L. Slusher ◽  
Tiffany M. Zúñiga ◽  
Edmund O. Acevedo
Keyword(s):  
Gene Expression ◽  
Young Adults ◽  
Telomere Length ◽  
Immune Cell ◽  
Ex Vivo ◽  
Middle Aged ◽  
Human Telomerase Reverse Transcriptase ◽  
Negatively Associated ◽  
Htert Gene ◽  
Age Related

Age-related elevations in proinflammatory cytokines, known as inflamm-aging, are associated with shorter immune cell telomere lengths. Purpose. This study examined the relationship of plasma PTX3 concentrations, a biomarker of appropriate immune function, with telomere length in 15 middle-aged (40-64 years) and 15 young adults (20-31 years). In addition, PBMCs were isolated from middle-aged and young adults to examine their capacity to express a key mechanistic component of telomere length maintenance, human telomerase reverse transcriptase (hTERT), following ex vivo cellular stimulation. Methods. Plasma PTX3 and inflammatory cytokines (i.e., IL-6, IL-10, TGF-β, and TNF-α), PBMC telomere lengths, and PBMC hTERT gene expression and inflammatory protein secretion following exposure to LPS, PTX3, and PTX3+LPS were measured. Results. Aging was accompanied by the accumulation of centrally located visceral adipose tissue, without changes in body weight and BMI, and alterations in the systemic inflammatory milieu (decreased plasma PTX3 and TGF-β; increased TNF-α (p≤0.050)). In addition, shorter telomere lengths in middle-aged compared to young adults (p=0.011) were negatively associated with age, body fat percentages, and plasma TNF-α (r=−0.404, p=0.027; r=−0.427, p=0.019; and r=−0.323, p=0.041, respectively). Finally, the capacity of PBMCs to increase hTERT gene expression following ex vivo stimulation was impaired in middle-aged compared to young adults (p=0.033) and negatively associated with telomere lengths (r=0.353, p=0.028). Conclusions. Proinflammation and the impaired hTERT gene expression capacity of PBMCs may contribute to age-related telomere attrition and disease.

Age-related effects on the neural processing of semantic complexity in a continuous narrative: Modulation by gestures already present in young to middle-aged adults

2021 ◽  
Vol 151 ◽  
pp. 107725
Author(s):  
Paulina Cuevas ◽  
Yifei He ◽  
Jutta Billino ◽  
Elisa Kozasa ◽  
Benjamin Straube
Keyword(s):  
Neural Processing ◽  
Middle Aged ◽  
Age Related ◽  
Semantic Complexity ◽  
Middle Aged Adults ◽  
Continuous Narrative

165 Sex differences in the relationship between self-reported sleep quality and frailty in South Florida older adult outpatients

SLEEP ◽  
2021 ◽  
Vol 44 (Supplement_2) ◽  
pp. A67-A67
Author(s):  
Sonya Kaur ◽  
Katalina McInerney ◽  
Mitchell Slugh ◽  
Annelly Bure ◽  
Marina Sarno ◽  
...  
Keyword(s):  
Older Adults ◽  
Sex Differences ◽  
Sleep Quality ◽  
Grip Strength ◽  
Brain Research ◽  
Functional Independence ◽  
South Florida ◽  
Left Hand ◽  
Depression Status ◽  
The Relationship

Abstract Introduction Frailty, a multidimensional construct of decreased reserve is an important predictor of functional independence and quality of life in older adults. There is a growing body of evidence highlighting reduced sleep efficiency and sleep duration predicts frailty in older adults. However, the sex differences in these relationships have been understudied. Methods 253 participants (163) ranging in age from 50-92 years (mean= 67.59 years, S.D.= 9.22 years), underwent frailty assessment and completed the Pittsburgh Sleep Quality Index (PSQI) and the Epworth Sleepiness Scale (ESS). Statistical moderation was assessed using nonparametric bootstrapping. All models statistically controlled for age, education and depression status. Results Higher scores on the PSQI predicted higher levels of fatigue (β=1.87, 95% CI= 0.48-3.27) and higher grip strength with the left hand (β= 0.81, 95% CI= 0.85-1.53). These relationships were significantly moderated by sex (β=-0.77, p=0.05 & β=-0.52, p=0.01). Specifically, high scores on the PSQI predicted more fatigue stronger grip strength in men (β=1.11, 95% CI=0.41-1.81) and weaker grip strength in women (β=-0.25, 95% CI=-0.51--0.02). There was no association between scores on the ESS and any of the frailty measures. Conclusion The relationships between PSQI scores and measures of fatigue and grip strength were statistically moderated by sex. These differences are not explained by sex differences in overall sleep quality or baseline frailty. This is consistent with the literature emphasizing sex differences in the effects of risk/lifestyle factors. It is possible that the relationship between sleep quality and frailty is altered by additional hormonal factors and warrant further investigation. Support (if any) This research was supported by the Evelyn F. McKnight Brain Research Foundation

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