Disturbed sleep and reduced hippocampal integrity at midlife: Implications for AD risk in women with early surgical menopause

The objective: to determine the efficacy of medicine «Menopace» in treatment of women with natural and surgical menopause. Patients and methods. 20 women (I group) with a natural menopause were examined (basic subgroup consisted of 10 patients who used Menopace for 3 months; control subgroup consisted of 10 patients). 20 women (II group) with surgical menopause were examined (basic subgroup consisted of 10 patients who received Menopace for 3 months; control subgroup consisted of 10 patients). Results. The average score of neurovegetative and emotional manifestations of climacteric syndrome during the observation period decreased in women with natural and surgical menopause who used Menopace, compared with subgroups of patients who had not used the medicine. Conclusions. 1. The use of the medicine Menopace in women with natural menopause after 3 months showed the disappearance of clinical symptoms of climacteric syndrome in 70% of the cases, and significant improvement in general condition in 30% of cases. 2. During surgical menopause after 1 month of treatment with Menopace manifestations of sweating were observed 4.5 times less often than in control group, tides were observed 7 times less often than in control group. Neurovegetative and psychoemotional symptoms of menopause were absent in 80% of women after 3 months of treatment and in 20% of cases significant improvement was shown. 3. The obtained results give grounds to recommend wide use of Menopace in practical work for the treatment of menopausal syndrome during natural and surgical menopause. Key words: menopause, therapy, Menopace.

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Potential predictive marker of treatment effectiveness in patients with osteopenic syndrome after surgical menopause

GYNECOLOGY ◽

10.26442/20795696.2020.4.200188 ◽

2020 ◽

Vol 22 (4) ◽

pp. 39-42

Author(s):

Yansiiat Z. Zaydieva ◽

Elena V. Kruchinina ◽

Olga S. Gorenkova ◽

Elena Yu. Polyakova ◽

Elena N. Kareva ◽

...

Keyword(s):

Vitamin D ◽

Combination Therapy ◽

Vitamin D Receptor ◽

Surrogate Marker ◽

Predictive Marker ◽

Expression Level ◽

Mineral Density ◽

Vitamin D Receptors ◽

Surgical Menopause

Introduction. Patients with surgical menopause have a risk for osteopenic syndrome (OS). Menopausal hormone therapy (MHT) in combination with calcium and vitamin D promotes increase in bone mineral density (BMD). The expression level of vitamin D receptor in mononuclear fraction cells (MNFC) of blood can be considered as a predictive marker of effectiveness of OS therapy. Aim. To search a molecular predictive marker of the effectiveness of OS treatment. Materials and methods. The study included 100 women aged 4055 years with a duration of surgical menopause from 12 months to 6 years. The criterion for including patients in the study was the absence of contraindications to the use of MHT. The subject of the study was the determination of BMD by dual-energy X-ray absorptiometry, polymerase chain reaction diagnostics of the level of expression of vitamin D genes, estradiol and progesterone receptors, determination of 25-OH vitamin D in the blood. Results. Analysis of 12-month OS therapy effectiveness evaluated with a surrogate marker BMD. The increase in BMD up to 34% per year was treated as absence of negative dynamics, more than 4% per year as positive one. Significant effect of combination therapy compared with MHT on BMD in patients with surgical menopause with a low baseline level of BMD (due to hypovitaminosis D) is associated with the anti-inflammatory, bone-protective effect of vitamin D. In both groups of patients not responding; to the prescribed therapy we were able to conduct a comparative analysis of expression level of the target molecules in the MNFC before the start of treatment. The efficacy of MHT and combination therapy for BMD disorders is positively associated with the expression level of vitamin D receptors in MNFC before treatment. Therefore, the vitDR mRNA level is a potential predictive marker of the effectiveness of OS treatment. The expression levels of nuclear estradiol beta receptor and membrane receptor for progesterone in MNFC before treatment showed an upward trend in women responding to therapy. Conclusion. The expression level of the vitamin D receptor in MNFC of blood is significantly lower in the group of women with no/insufficient effect on 12-month combined therapy. This indicator can be considered as a predictive marker of the effectiveness of OS therapy.

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Faculty Opinions recommendation of Effects of disturbed sleep on gastrointestinal and somatic pain symptoms in irritable bowel syndrome.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.726389937.793520532 ◽

2016 ◽

Author(s):

Adam Farmer

Keyword(s):

Irritable Bowel Syndrome ◽

Somatic Pain ◽

Disturbed Sleep ◽

Irritable Bowel ◽

Pain Symptoms

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DIAGNÓSTICOS DE ENFERMAGEM DE MULHERES NUTRIZES ATENDIDAS NO BANCO DE LEITE HUMANO

Enfermagem em Foco ◽

10.21675/2357-707x.2019.v10.n1.1396 ◽

2019 ◽

Vol 10 (1) ◽

Cited By ~ 1

Author(s):

Nathália Carolina Tomazelli Crespo ◽

Rosimere Ferreira Santana ◽

Valdecyr Herdy Alves ◽

Audrey Vidal Pereira ◽

Giovanna Rosario Soanno Marchiori ◽

...

Keyword(s):

Human Milk ◽

Sleep Pattern ◽

No Donors ◽

Tissue Integrity ◽

Disturbed Sleep ◽

Nursing Diagnosis ◽

Milk Bank ◽

Las Mujeres ◽

Human Milk Bank ◽

Milk Banks

Objetivo: conhecer o perfil de Diagnósticos de Enfermagem em mulheres nutrizes atendidas no Banco de Leite Humano. Metodologia: estudo descritivo, com 30 mulheres atendidas no Banco de Leite Humano entre doadoras e não doadoras. Os dados foram coletados nos meses de março a maio de 2012. A análise se deu por meio de estatística descritiva. Resultados: os diagnósticos foram descritos para dois grupos: Não doadoras: Disposição para conhecimento melhorado (100,0%), Risco de infecção (80,9%), Integridade Tissular prejudicada (80,9%), Padrão de sono prejudicado (76,1%), Conhecimento deficiente (66,6%), Ansiedade (52,3%); Em Doadoras: Padrão de sono prejudicado (77,7%) e Ansiedade (55,5%). Conclusão: a taxonomia diagnóstica encontra-se de acordo com a população estudada. Validou-se a necessidade do uso dessa tecnologia como um sistema padrão de linguagem.Descritores: Bancos de leite; Diagnóstico de enfermagem; Cuidados de enfermagem; Saúde da mulher; Aleitamento materno.NURSING DIAGNOSIS IDENTIFIED IN WOMEN AT THE HUMAN MILK BANKObjective: to know the profile of Nursing Diagnosis in women hosted in the Human Milk Bank. Methodology: descriptive study, with 30 women attended at the Human Milk Bank between donors and no donors. Data were collected from March to May 2012. The analysis was done through simple descriptive statistics. Results: diagnosis were described for two groups: No donors: Readiness for enhanced knowledge (100.0%), Risk for infection (80.9%), Impaired tissue integrity (80.9%), Disturbed sleep pattern (76.1%), Deficient knowledge (66.6%), Anxiety (52.3%); In Donors: Disturbed sleep pattern (77.7%) and Anxiety (55.5%). Conclusion: the diagnostic taxonomy is in agreement with the studied population. The need to use this technology as a standard language system was validated.Descriptors: Milk banks; Nursing diagnosis; Nursing care; Women’s health; Breastfeeding.ENFERMERÍA DE DIAGNÓSTICO IDENTIFICADOS EN MUJERES ASISTIDA EN BANCO DE LECHE HUMANAObjetivo: conocer el perfil de los diagnósticos de enfermería de las mujeres dio la bienvenida al Banco de Leche Humana. Metodology: estúdio descriptivo, con 30 mujeres atendidas enel Banco de Leche Humana entre los donantes y no donantes. Los datos fueron recolectados entre marzo y mayo de 2012. El análisis se realizó utilizando estadísticas descriptivas simples. Resultados: los diagnósticos han sido descritos por dos grupos: No donantes: Disposición para mejorar los conocimientos (100%), Riesgo de infección (80,9%), Deterioro de la integridade cutánea (80,9%), Trastorno del patrón de sueño (76, 1%), Conocimientos deficientes (66,6%), Ansiedad (52,3%); Em Donantes: Trastorno del patrón de sueño (77,7%) y Ansiedad (55,5%). Conclusión: la taxonomía diagnóstica es función de la población estudiada. Han verificado la necesidad de la utilización de esta tecnología como un sistema estándar de lenguaje.Descriptores: Bancos de leche; Diagnóstico de enfermería; Atención de enfermería; Salud de lamujer; Lactancia materna.

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