Possibilities of correction of menopausal disorders in women with the use of medicine Menopace

2016 ◽  
pp. 95-100
Author(s):  
G.I. Reznichenko ◽  
◽  
N.Yu. Reznichenko ◽  
V.Yu. Potebnya ◽  
K.I. Kovalenko ◽  
...  
Keyword(s):  
General Condition ◽  
Clinical Symptoms ◽  
Average Score ◽  
Control Group ◽  
Climacteric Syndrome ◽  
Basic Subgroup ◽  
Menopausal Syndrome ◽  
Natural Menopause ◽  
Surgical Menopause ◽  
Observation Period

The objective: to determine the efficacy of medicine «Menopace» in treatment of women with natural and surgical menopause. Patients and methods. 20 women (I group) with a natural menopause were examined (basic subgroup consisted of 10 patients who used Menopace for 3 months; control subgroup consisted of 10 patients). 20 women (II group) with surgical menopause were examined (basic subgroup consisted of 10 patients who received Menopace for 3 months; control subgroup consisted of 10 patients). Results. The average score of neurovegetative and emotional manifestations of climacteric syndrome during the observation period decreased in women with natural and surgical menopause who used Menopace, compared with subgroups of patients who had not used the medicine. Conclusions. 1. The use of the medicine Menopace in women with natural menopause after 3 months showed the disappearance of clinical symptoms of climacteric syndrome in 70% of the cases, and significant improvement in general condition in 30% of cases. 2. During surgical menopause after 1 month of treatment with Menopace manifestations of sweating were observed 4.5 times less often than in control group, tides were observed 7 times less often than in control group. Neurovegetative and psychoemotional symptoms of menopause were absent in 80% of women after 3 months of treatment and in 20% of cases significant improvement was shown. 3. The obtained results give grounds to recommend wide use of Menopace in practical work for the treatment of menopausal syndrome during natural and surgical menopause. Key words: menopause, therapy, Menopace.

scholarly journals Evaluation of the effectiveness of ARVI treatment regimen including etiotropic (enisamium iodide) and symptomatic treatment

2020 ◽  
Vol 92 (3) ◽  
pp. 50-55
Author(s):  
D. A. Lioznov ◽  
E. J. Karnaukhova ◽  
T. G. Zubkova ◽  
E. V. Shakhlanskaya
Keyword(s):  
Influenza A ◽  
Viral Infections ◽  
Clinical Symptoms ◽  
Randomized Study ◽  
Antiviral Drug ◽  
Main Group ◽  
Average Score ◽  
Control Group ◽  
Symptomatic Therapy ◽  
Respiratory Viral Infections

Aim. To assess the effectiveness of the use of the antiviral drug enisamium iodide in the complex treatment of acute respiratory viral infections (ARVI) caused by various pathogens in routine clinical practice. Materials and methods. А prospective randomized study included 134 patients who were treated in the epidemic season of influenza and ARVI in 20182019. All patients were examined for the presence of influenza A and B viruses, respiratory syncytial virus, human metapneumovirus, parainfluenza virus, coronaviruses, rhinoviruses, adenoviruses in nasopharyngeal swabs by PCR. Patients of the main group received enisamium iodide along with symptomatic therapy, the control group received only symptomatic therapy. The primary parameter of the effectiveness of therapy was evaluated on the scale of the general severity of the manifestations of ARVI (Total Symptom Score TSS) from the 2nd to the 4th day and by the secondary criteria of effectiveness: assessment of the duration of ARVI, the severity of fever, the proportion of patients with normal body temperature, the duration of the main clinical symptoms of acute respiratory viral infections, the proportion of patients in whom complications requiring antibiotics were noted, the dynamics of interferon status on the 6th day. To conduct a statistical analysis, depending on the efficiency parameter, the ANCOVA method with a fixed group factor and an initial score on the TSS severity scale was used as covariates, a criterion for comparing quantitative indicators in two independent groups. Results. According to the results of the analysis of the primary efficacy parameter, the median (interquartile range) of the average score on the scale of the general severity of ARVI manifestations in the main group was 4.33 (3.675.83), in the comparison group 6.00 (4.677.25; p0.001). The duration of systemic and local manifestations of acute respiratory viral infections was statistically significantly less in the main group (p=0.002 and p=0.019, respectively). Prescription of additional therapy was required in 2 (2.9%) patients of the main group (patients taking enisamium iodide), compared with 8 (11.9%) patients in the control group. Serum levels of interferon  and interferon  on the last day of treatment were statistically significantly higher in patients of the main group compared with the control group (p0.001). Treatment (excellent) was evaluated by 42 (62.7%) patients, while in the control group only 17 (25.8%) patients gave similar ratings. Both patients (p0.001) and doctors (p0.002) rated therapy tolerance better in the study group. Conclusion. The results confirmed the safety and effectiveness of enisamium iodide as a treatment for ARVI and influenza. The antiviral, interferonogenic and anti-inflammatory properties of the drug are involved in the formation of an antiviral response and reduce the risk of complications, which makes it possible to reduce the number of symptomatic agents used.

Indicators of the immune system after correction of climacteric syndrome in women with uterine leiomyoma and endometrial hyperplasia

2020 ◽  
pp. 72-79
Author(s):  
L.I. Butina ◽  
◽  
L.P. Shelestova ◽  
F.A. Khancha ◽  
A.L. Ostroukh ◽  
...  
Keyword(s):  
Immune System ◽  
Uterine Leiomyoma ◽  
Endometrial Hyperplasia ◽  
Control Group ◽  
Climacteric Syndrome ◽  
Natural Menopause ◽  
Healthy Women ◽  
Prevention And Treatment ◽  
Before And After ◽  
One Year

The objective: to evaluate the effectiveness of the correction of climacteric syndrome (CS) with the use the method of sequential prevention and treatment of CS in women with uterine leiomyoma (UL) and endometrial hyperplasia (EH) based on studies of indicators of the immune system. Materials and methods. On the basis of prognosis using a mathematical model some groups of women with UL and EH in the period of before and after menopause, with the risk of development of disorders in menopause were chosen and the state of the immune system before and after the correction of climacteric syndrome with the use the method of sequential prevention and treatment of CS were evaluated. The prevention of CS was carried out in 184 women aged 40 to 53 years with the presence of signs of UL and EH, in which after menstruation was delayed for 3–6 months, uterine bleeding and symptoms of CS were observed. These women underwent CS prevention for one year with the use of a contraceptive containing of the natural estrogen estradiol valerate and gestagen dienogest. The women were divided into groups depending on the presence or absence of signs of CS, UL and EH: women with UL and CS (n=60), women with UL without CS (n=37), women with EH and CS (n=37), women with EH without CS (n=25), women with CS without UL and EH (n = 25). Women with UL and CS who constituted the main group (n=60), additionally used an immunomodulator that contains meglumine acridonacetate and suppositories containing recombinant alpha interferon 2. The control group consisted 50 women of the same age category without the presence of CS, UL and EH After the prevention in 24 women of the main group (n=60), the menstrual function was recovered and the symptoms of CS disappeared. In remaining 36 women the menopause was developed and they amounted to 1 treatment-and-prophylactic (1-T-P) group of women who were prescribed the treatment complex developed and proposed by us. In these women we investigated the effectiveness of the correction of climacteric syndrome with the use the method of sequential prevention and treatment of symptoms of CS. The treatment of CS, which included a complex of drugs: a combined herbal preparation containing cimicifuga, a preparation from the microalgae Spirulina platensis, pectin and a drug with the active substance mebicar, was carried out for one year in 193 women aged 48 to 60 years. These women consisted of women with UL and CS after prophylaxis – 1 treatment-and-prophylactic (1-T-P) group (n=36), of women without prior prevention: women with UL, CS and natural menopause – 1-treatment (1-T) group (n=31), women of 2 – treatment (2-T) group with UL without CS (n=40), women of 3 – treatment (3-T) group with EH and CS (n=25), women of 4 – treatment (4-T) group with EH without CS (n=27), women of 5 – treatment (5-T) group with CS without UL and EH (n=34). The control group consisted of 35 women of the same age category without the presence of UL, EH and CS. The signs of uterine leiomyoma (UL) and endometrial hyperplasia (EH) were determined according to ultrasound examination of the uterine and the results of histological investigations of the endometrium. The intensity of the symptoms of CS was evaluated using a modified Cooperman index (MCI). To assess the effectiveness of correction of CS in women with UL and EH by an enzyme immunoassay, the level of Ig A, G, M, interleukins 1 and 2 (IL-1, IL-2) of tumor necrosis factor (TNF) was studied before and after the use of prevention and treatment of CS. Group comparisons were performed using the angular Fischer transform. Parametric indicators at normal distribution were compared using Student’s t criterion. In the work, their quantitative values are given in the form of arithmetic mean and its error. Results. After the treatment in women with EH and CS (n=25) in women with CS without UL and EH (n=34) indicators of humoral immunity IgA, IgM, IgG, IL-1, IL-2 and TNF did not significantly differ from those in healthy women in the menopause (р>0,05). In women after consistent prevention and treatment of CS of 1 T-P group (n=36), we observed the increase of the level of IgA for 29%, IgM for 25%, decrease the level of IL-1 to 1,3 times, and TNF level – to 1,8 times. In women without prophylaxis of CS of 1-T group (n=31) we observed the increase of the level of IgA for 25%, IgM for 19%, compared with the indicators before the treatment (р<0.05), and the IgG and TNF level after the treatment does not differ from the indicators in healthy women in the menopause (р>0.05), the level of the IL-1 remained to 1,6 times higher compared with healthy women (р<0.05). The consistent use of prevention and treatment by our worked out method allows to reduce the intensity of CS in women with UL and CS after prevention (n=36) according to the MCI data by 1,26 times in comparison with women in the group with CS, UL and natural menopause (n=31), by 1,28 times in comparison with women in the group with EH and CS (n=25), by 1,39 times in comparison with women in the group with CS without UL and EH (n=25) after treatment according to our method, without previous prevention. Conclusions. The application of the correction of CS with the use of the method of consistent prevention and treatment of CS allows to reduce the intensity of symptoms of CS in women with UL and CS according to the MCI data by 1.26–1.39 times, recover the indicators of humoral link of immune system and prevent the exhaustion of antitumor protection factors. Keywords: climacteric syndrome, prevention, treatment, uterine leiomyoma, endometrial hyperplasia, immune system.

scholarly journals Search of ways to menopausal hormonal therapy and correction of bacterial vaginosis against the climacteric syndrome

2021 ◽  
pp. 73-78
Author(s):  
G.I. Reznichenko ◽  
N.Y. Reznichenko
Keyword(s):  
Bacterial Vaginosis ◽  
Standard Treatment ◽  
High Efficiency ◽  
Life Quality ◽  
Control Group ◽  
Climacteric Syndrome ◽  
Natural Menopause ◽  
Study Objective ◽  
Micronized Progesterone

Study objective: optimization of the treatment of climacteric syndrome (CS) and improvement of the life quality in women with bacterial vaginosis (BV) during menopause. Materials and methods. 58 women with natural menopause were examined, 38 of whom were diagnosed with BV. To correct the CS patient used the drug 17β-estradiol Divigel transdermal in combination with micronized progesterone orally. Patients with BV were divided into 2 subgroups: 15 women received standard treatment with metronidazole gel (comparison subgroup), 23 women additionally used Lactagel (main subgroup). The control group included 20 patients with CS without BV. The severity of CS was assessed with MRS scale. Microscopic and bacteriological examination of vaginal discharge was performed to determine the infectious agent, and the species composition of pathogens was determined with a polymerase chain reaction. BV was diagnosed according to Amsel criteria. CQLS questionnaire was used to assess the quality of life of patients with BV. The treatment effectiveness was assessed after 1 and 3 months from the start of treatment.Results. Divigel in women with uterus in combination with oral micronized progesterone has shown high efficiency in the CS correction within a month from the start of treatment. The most significant was the decrease in neurovegetative and psychoemotional symptoms after 3 months from the start of treatment. Lactagel in the therapy of patients with BV on the background of CS allowed increasing the lactobacilli content to the value in patients without BV, restoring the normal vaginal biotope and preventing of the disease recurrence, in contrast to the subgroup of patients who received standard treatment. Lactagel made it possible to improve the life quality of patients to an average level and to increase the overall level of life satisfaction, in contrast to the subgroup with standard treatment where these levels have remained low.Conclusions. Developed approaches to menopausal hormone therapy and BV therapy against the background of natural menopause allows optimizing treatment, improving the life quality of patients, which allows recommending them for widespread use in clinical practice.

Analysis of clusters of menopausal disorders associated with a decrease in the quality of life in postovarectomy and climacteric syndromes

2021 ◽  
pp. 64-71
Author(s):  
Neufeld I.V. ◽  
Bobyleva I.V. ◽  
Zhirnyakov A.I. ◽  
Kuznetsova M.V. ◽  
Rogozhina I.E.
Keyword(s):  
Quality Of Life ◽  
Sleep Disturbances ◽  
Estrogen Deficiency ◽  
Menopausal Symptoms ◽  
Moderate Degree ◽  
Bilateral Oophorectomy ◽  
Menopausal Syndrome ◽  
Natural Menopause ◽  
Surgical Menopause

The decline in the quality of life due to various menopausal disorders in the early postmenopausal period is actually the main reason that leads a woman to seek medical help. Despite this, not enough attention is paid to this problem. Currently, the concept of the formation of individual menopausal symptoms into clusters is emerging to optimize treatment and diagnostic algorithms for managing this category of patients. The aim was a comparative analysis of the menopausal disorders most associated with a decrease in the quality of life. Included were 230 women with climacteric disorders (95 with bilateral oophorectomy; 135 with natural menopause). The assessment of the severity of climacteric disorders was carried out according to the Kuperman index modified by E.V. Uvarova. The SF-36 Health Status Survey was used to assess the quality of life. The average age of patients with surgical menopause was 47.9±2.2 years, with natural menopause - 53.6±3.5 years (p˂0.05). The duration of the estrogen deficiency state in the groups was comparable - 2.8 ± 0.6 years (p>0.05). All patients had a moderate degree of menopausal syndrome (p>0.05), however, the values of the modified menopausal index differed significantly: with postovarectomy syndrome - 57.8±1.1 points, with menopausal syndrome - 49.7±0.9 points (р <0.05). In both groups, a decrease in the quality of life was observed: the total physical component (with postovarectomy syndrome up to 57.2 (36.6; 72.7), with menopause - up to 68.4 (49.3; 83.5)) and the total psychological component (up to 53.9 (42.9; 76.7) and 64.1 (47.3; 84.5), respectively). In contrast to our approach, the formation of clusters of menopausal symptoms, based on the generally accepted approach to the analysis of climacteric disorders (psychological, vasomotor, somatic), provided a significantly smaller sample coverage (with surgical menopause - 68.5%, with natural - 62.6% variance) With a duration of estrogen deficiency of 2.8 ± 0.6 years, the cluster of menopausal disorders, which has the maximum negative effect on the quality of life, includes symptoms: hot flashes, cognitive disorders, sleep disturbances, anxiety, and covers 80.3% of the variance in postovarectomy syndrome, in menopausal - 73.6%. Knowledge of this fact contributes to the identification of risk groups and allows formulating new algorithms for the management of postmenopausal women.

scholarly journals SPONTANEOUS SYMULIDOTOXICOSE OF CATTLE IN СОNDITIONS THE CENTRAL NON-CNERNOZEM ZONE OF RUSSIA

2019 ◽  
pp. 174-177
Author(s):  
Vasilevich ◽  
Zinovieva ◽  
Kaplich
Keyword(s):  
Clinical Symptoms ◽  
Natural Resistance ◽  
Control Group ◽  
Immune Reactivity ◽  
Blood Profile ◽  
Maximum Change ◽  
Morphological Composition ◽  
Young Cattle ◽  
Experimental Group ◽  
Observation Period

Studies have been conducted on the acute course of simulidotoxicosis of young cattle in the territory of the central non-chernozem zone of Russia. The changes in the morphological composition of the blood, immune reactivity and natural resistance of animals with simulidotoxicosis were studied. Simulids as active bloodsuckers cause a decrease in animal productivity. In addition, they are specific and mechanical carriers of pathogens of a number of animal diseases. In the study area, there are frequent cases of the disease simulidotoxicosis, often ending in the death of animals, especially young cattle.A comparative analysis has shown that the manifestation of acute simulidotoxicosis is similar in young and adult animals. Blood was examined after 4, 8, 12, 24, 48 and 96 hours to study the morphological and biochemical parameters of the disease. The following cases were registered 4 hours after the onset of the clinical picture with spontaneous simuliotoxicosis: the erythrocytes in the experimental group were lower by 14.6% compared with the control group. Leukocytes were increased by 47.7%, hemoglobin was decreased by 2.5%. The dynamics of changes after 48 hours after the onset of the disease red blood cells decreased by 36.8%, leukocytes increased by 49.2%, hemoglobin decreased by 52.1%. After 8–24 hours, leukopenia is noted in animals, but after 48 hours the blood profile lines up. There is a decrease in leukocytes, a decrease in total protein and albumin during the entire observation period. When studying leukograms, eosinophilia was noted with an increased content of stab and segmented neutrophils, with a maximum change of 48 hours from the onset of the first symptoms of the disease in animals. Еrythropenia with anemia is characteristic of natural simulidotoxicosis at the onset of the disease, and leukopenia is registered on the first 24 hours after the onset of clinical symptoms, which after 48 hours of observation is replaced by leukocytosis.

scholarly journals Experience with alternative therapies in women with menopausal metabolic syndrome

2021 ◽  
Vol 1 ◽  
pp. 26-28
Author(s):  
O.V.  Stefanovskaya ◽  
L.V. Akker ◽  
A.I.  Galchenko
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Alternative Therapies ◽  
Middle Level ◽  
Climacteric Syndrome ◽  
Anthropometric Parameters ◽  
Menopausal Syndrome ◽  
Natural Menopause ◽  
Lipid Exchange ◽  
The Metabolic Syndrome

You study the influence of alternative therapies drug «Klimadynon®» in menopausal’nym patients with metabolic syndrome in the climacteric syndrome, weight, blood pressure, carbohydrate and lipid metabolism. Surveyed 38 patients aged 45 to 61 years (mean age 53,6±0,6 years) who were in natural menopause and had a series of violations within the framework of the metabolic syndrome (excess weight or obesity on abdominal’nomu type 2, type IMD dislipidemiu, arterial hypertension). Correction for climacteric disorders has been appointed an alternate method of treatment – «Klimadynon®» to 1 tablet 2 times daily. Estimated climacteric syndrome using modified menopausal index (E.V. Uvarova, 1983), carbohydrate, lipid Exchange, anthropometric parameters, level of HELL originally, after 3 and 6 months of initiating treatment. Against the backdrop of the reception of an alternative method of treatment with «Klimadynon®» we got the better of menopausal syndrome: in 13,3 % of heavy gravity menopausal syndrome has moved to middle level, in 52,6 % of the average degree of menopausal syndrome has moved into easy. Accurately noted improvements in the level of blood sugar on an empty stomach, reducing insulinorezisten- tnosti in women with menopausal’nym metabolic syndrome with therapy. «Klimadynon®» anticonvulsant therapy has statistically significant antiaterogennomu shift indicator of lipid Exchange in women. A tendency towards lower body mass index, waist, blood pressure. Thus, the application of the «Klimadynon®» in women with abnormal klimaksom and menopausal’nym metabolic syndrome could be a good option alternative therapies and significantly improve their quality of life.

scholarly journals THE STUDY OF PATHOGENIC PROPERTIES OF ENTEROCOCCI ISOLATED FROM THE CARPATHIAN CHEESE

2020 ◽  
Vol 21 (1) ◽  
pp. 119-125
Author(s):  
I. I. Kushnir
Keyword(s):  
Body Weight ◽  
Clinical Condition ◽  
Clinical Symptoms ◽  
Light Stimulus ◽  
Acute Poisoning ◽  
Laboratory Animals ◽  
Control Group ◽  
Anaerobic Microorganisms ◽  
Observation Period

The article present the results of the studies pathogenic properties of enterococci isolated from the Carpathian brynza. Due to the high enzymatic activity enterococci give food unique taste properties. However, scientists have an ambiguous attitude to them, primarily due to the acquisition of resistance to antimicrobials by these microorganisms, and the ability of certain species to cause various diseases in humans and animals. In the determining of infectivity was found that the intra-gastric administration of live enterococci at a dose of 108 CFU per animal, and in the study of toxicity - inactivated microorganisms, white mice remained alive. During the 14-day of observation period, the laboratory animals were active, had a satisfactory appetite, and maintained reflex excitability for sound and light stimulus. Therefore, the studied strains of enterococci E. durans SB6, E. faecium SB 12, E. durans SB18, E. durans SB20 are not infectious and non-toxic, as they did not cause any clinical symptoms and abnormalities in the overall condition of white mice. The tested strains of enterococci don’t have enzymes which are related to the factors of pathogenicity, in particular, they did not have the catalase activity, which have pathogenic aerobic and facultative anaerobic microorganisms, did not produce lecithinase, which causes the de-polymerization of cell membranes of the microorganisms. In addition, the tested microorganisms did not produce plasma-coagulase and fibrinolysin that indicate on the apatogenic properties of the studied microorganisms. The tested strains of enterococci did not cause an irritating effect on the mucous membrane of the eye. In the determination of acute toxicity, it was found out that intra-gastric administration of the tested strains did not cause signs of acute poisoning, death and diseases of laboratory animals. At the same time, during the 14-day of observation period, no changes in the clinical condition were detected in the animals. In long-term use of enterococci, for 28 days, no changes in the clinical condition of laboratory animals were detected, but observed an increase in body weight of the animals. In particular, on the 28th day of the experiment was noted an increase in body weight of the animals which were administered strains of E. durans SB6, E. faecium SB 12, E. durans SB18, E. durans SB20, respectively, on 7.7, 7.5, 7, 32 and 10.2 %, compared to the values of animals of the control group.

Changes in Platelet Aggregability after Ovariectomy

1979 ◽  
Vol 42 (04) ◽  
pp. 1332-1339 ◽  
Author(s):  
Hiroh Yamazaki ◽  
Takeshi Motomiya ◽  
Minoru Sonoda ◽  
Noboru Miyagawa
Keyword(s):  
Platelet Count ◽  
Platelet Activation ◽  
Ovarian Hormones ◽  
Control Group ◽  
Platelet Aggregability ◽  
Appearance Rate ◽  
Before And After ◽  
The Difference ◽  
Induced Aggregation ◽  
Observation Period

SummaryChanges in platelets in 48 patients with uterine myoma before and after hysterectomy with and without ovariectomy were examined. Bilateral ovariectomy in 25 cases (ovariec-tomized group) and unilateral or non-ovariectomy in 23 cases (control group) were performed at the hysterectomy. Platelet count and an appearance rate of secondary aggregation decreased at one day after and increased at one week after the operation, similarly in both the ovariectomized and the control group. The appearance rate of secondary aggregation was reflected in an intensity of aggregation at 5 min after the addition of reagent to PRP. At one month after the operation, the appearance rate of secondary aggregation induced by 3 μM ADP showed a statistically significant decrease in comparison with the preoperation value (P <0.05) and the enhancement of 5-min aggregation was still observed in the control group, while ceased in the ovariectomized group. The difference between the two groups was significant (P < 0.05). There was almost no change in the speed and intensity of primary and secondary aggregation during the observation period. No significant differences in collagen-induced aggregation were noted between the two groups. The results suggest that ovarian hormones, mainly estrogen, facilitate platelet activation which is mediated by the so-called secondary aggregation.

Penerapan Model Pembelajaran Problem Based Learning dalam Pembelajaran Matematika di Kelas VIII SMPN 28 Padang

2017 ◽  
Vol 1 (2) ◽  
pp. 225-236
Author(s):  
Andi Susanto ◽  
Sony Ariadi
Keyword(s):  
High School ◽  
Problem Solving ◽  
Junior High School ◽  
Problem Based Learning ◽  
Average Score ◽  
Control Group ◽  
Learning Problem ◽  
Math Ability ◽  
Class Viii ◽  
Randomized Control

This reseach is aimed at knowing the students ability in both solving the math problem and connection those who are taught by Problem Based Learning at class VIII of the Junior High school 28 Padang 2017/2018. This research is categorized as quasy Experimental Research, by using Randomized Control Group Only Design. After implementing the Problem Based Leaning, the student was directly given the test as the result showed that the score  of the student who belong to the experimental class in  problem solving recorded as 74,00 while those who were in the control class only refers to 72,30. The test average score on the experimental class in term of math connection ability was 68,73; while in the control class recorded as 62,43. The T- Test showed that T-Table equals to 1,64 with the degree of reliability 95% . This fact reveals that the students’ ability in solving the problem after being taught through Problem Based Learning is higher than in control class with T-count equals to 3,71; while their connection math ability through Problem Based Learning Model in the Experimental Class is higher than control with T-count 2.17.Keywords: Problem Based Learning, problem solving, mathematics connection

Modern approaches to the treatment of mastitis in women of reproductive age

2016 ◽  
pp. 191-108
Author(s):  
A.A. Sukhanova ◽  
◽  
Yu.M. Melnik ◽  
O.O. Karlova ◽  
◽  
...  
Keyword(s):  
Ultrasound Examination ◽  
Clinical Signs ◽  
Reproductive Age ◽  
Herbal Remedies ◽  
Control Group ◽  
Women Of Reproductive Age ◽  
Clinical Method ◽  
Gynecological Examination ◽  
Study Results ◽  
Observation Period

The aim of the study: to study the efficacy and safety of use Mastofemin in the treatment of various forms of mastitis in women of reproductive age. Materials and methods. The study included 62 women of reproductive age (mean age of 33.5±2.3 years) who were screened in the Kiev city center reproductive and perinatal medicine. Women were divided into 2 groups. The first (main) group consisted of 32 patients who received the proposed treatment using herbal remedies Mastofemin 1 capsule 2 times per day for 3 months; 30 patients of the second (control) group were under observation and received no treatment. These groups were representative and homogeneous on age, clinical symptoms and sonographic characteristics. The clinical method included evaluation of complaints of patients, anamnesis, presence of concomitant gynecologic pathology, inspection, palpation of the lymph nodes and the breast and obtaining a discharge from the nipples to conduct cytological examination, which allowed excluding from the study women with suspected malignancy of the process. All the patients were performed ultrasound examination of the breast. The review was supplemented with vaginal gynecological examination and ultrasound examination of small pelvis organs to assess the condition of the uterus and its appendages, the diagnosis of gynecological diseases. Results. Summarizing obtained in this study results one should stress the positive long-term effect of applying Mastofemin for the treatment of proliferative changes of the breast in women of reproductive age. This is manifested by a decrease in the intensity of clinical signs of mastitis, consistent with the results of sonographic control. Established positive dynamics in the treatment of cystic mastitis, dectective and when combined cystic mastopathy with dectective. In the control group of patients for a given observation period (6 months) no significant changes in clinical signs of mastitis and sonographic characteristics. Regression of disease has not occurred in any of the patients, in 2 patients increased sensitivity of the breast after 6 months moved to the soreness. Sonographic characteristics of mastitis during the observation period did not change. Thus, the use of Mastofemin aimed at pathogenetic treatment of mastitis and prevention of breast cancer. Conclusion. Application of Mastofemin during the treatment of mastitis in women of reproductive age significantly improves the clinical condition of patients; reduce the subjective and objective symptoms of the disease. The positive effect of the treatment with Mastofemin proved in the case of the treatment of sonographic following forms of mastitis: cystic mastopathy, cystic mastopathy with dectectasy. Mastofemin may be the drug of choice for complex conservative monotherapy in women of reproductive age with proliferative changes in the breast, and can also be used as part of complex treatment in patients with diffuse changes of the breast when combined with hyperplastic processes of the myometrium and endometrium. Keywords: mastopathy, breast gland, herbal medicine, herbal remedies, Mastofemin.

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