scholarly journals Stretch-Induced Drug Delivery from Superhydrophobic Polymer Composites: Use of Crack Propagation Failure Modes for Controlling Release Rates

2016 ◽  
Vol 55 (8) ◽  
pp. 2796-2800 ◽  
Author(s):  
Julia Wang ◽  
Jonah A. Kaplan ◽  
Yolonda L. Colson ◽  
Mark W. Grinstaff
Keyword(s):  
Drug Delivery ◽  
Crack Propagation ◽  
Polymer Composites ◽  
Failure Modes ◽  
Release Rates ◽  
Propagation Failure

scholarly journals Stretch-Induced Drug Delivery from Superhydrophobic Polymer Composites: Use of Crack Propagation Failure Modes for Controlling Release Rates

2016 ◽  
Vol 128 (8) ◽  
pp. 2846-2850 ◽  
Author(s):  
Julia Wang ◽  
Jonah A. Kaplan ◽  
Yolonda L. Colson ◽  
Mark W. Grinstaff
Keyword(s):  
Drug Delivery ◽  
Crack Propagation ◽  
Polymer Composites ◽  
Failure Modes ◽  
Release Rates ◽  
Propagation Failure

scholarly journals Innenrücktitelbild: Stretch-Induced Drug Delivery from Superhydrophobic Polymer Composites: Use of Crack Propagation Failure Modes for Controlling Release Rates (Angew. Chem. 8/2016)

2016 ◽  
Vol 128 (8) ◽  
pp. 2997-2997
Author(s):  
Julia Wang ◽  
Jonah A. Kaplan ◽  
Yolonda L. Colson ◽  
Mark W. Grinstaff
Keyword(s):  
Drug Delivery ◽  
Crack Propagation ◽  
Polymer Composites ◽  
Failure Modes ◽  
Release Rates ◽  
Propagation Failure

Crack Propagation and Local Failure Simulation of Reinforced Concrete Subjected to Projectile Impact Using RBSM

2016 ◽  
Author(s):  
Yoshihito Yamamoto ◽  
Soichiro Okazaki ◽  
Hikaru Nakamura ◽  
Masuhiro Beppu ◽  
Taiki Shibata
Keyword(s):  
Reinforced Concrete ◽  
Crack Propagation ◽  
High Velocity ◽  
Failure Modes ◽  
Concrete Structures ◽  
Constitutive Models ◽  
Local Failure ◽  
High Velocity Impact ◽  
Velocity Impact ◽  
Projectile Impact

In this paper, numerical simulations of reinforced mortar beams subjected to projectile impact are conducted by using the proposed 3-D Rigid-Body-Spring Model (RBSM) in order to investigate mechanisms of crack propagation and scabbing mode of concrete members under high-velocity impact. The RBSM is one of the discrete-type numerical methods, which represents a continuum material as an assemblage of rigid particle interconnected by springs. The RBSM have advantages in modeling localized and oriented phenomena, such as cracking, its propagation, frictional slip and so on, in concrete structures. The authors have already developed constitutive models for the 3D RBSM with random geometry generated Voronoi diagram in order to quantitatively evaluate the mechanical responses of concrete including softening and localization fractures, and have shown that the model can simulate cracking and various failure modes of reinforced concrete structures. In the target tests, projectile velocity is set 200m/s. The reinforced mortar beams with or without the shear reinforcing steel plates were used to investigate the effects of shear reinforcement on the crack propagation and the local failure modes. By comparing the numerical results with the test results, it is confirmed that the proposed model can reproduce well the crack propagation and the local failure behaviors. In addition, effects of the reinforcing plates on the stress wave and the crack propagation behaviors are discussed from the observation of the numerical simulation results. As a result, it was found that scabbing of reinforced mortar beams subjected to high velocity impact which is in the range of the tests is caused by mainly shear deformation of a beam.

Processing of Biodegradable Polymer Composites as A Drug Delivery System in Vitro

1999 ◽  
Vol 14 (4) ◽  
pp. 322-325
Author(s):  
S.-J. Liu ◽  
C.-H. Tsai ◽  
S.-S. Lin ◽  
S. W.-N. Ueng
Keyword(s):  
Drug Delivery ◽  
Polymer Composites ◽  
Drug Delivery System ◽  
Delivery System ◽  
Biodegradable Polymer

scholarly journals Modulating the Thermoresponse of Polymer-Protein Conjugates with Hydrogels for Controlled Release

Polymers ◽  
2021 ◽  
Vol 13 (16) ◽  
pp. 2772
Author(s):  
Vincent Huynh ◽  
Natalie Ifraimov ◽  
Ryan G. Wylie
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Ethylene Glycol ◽  
Solution Temperature ◽  
Residence Times ◽  
Release Rates ◽  
Critical Solution Temperature ◽  
Protein Conjugates ◽  
Particle Encapsulation ◽  
Glycol Methyl Ether

Sustained release is being explored to increase plasma and tissue residence times of polymer-protein therapeutics for improved efficacy. Recently, poly(oligo(ethylene glycol) methyl ether methacrylate) (PEGMA) polymers have been established as potential PEG alternatives to further decrease immunogenicity and introduce responsive or sieving properties. We developed a drug delivery system that locally depresses the lower critical solution temperature (LCST) of PEGMA-protein conjugates within zwitterionic hydrogels for controlled release. Inside the hydrogel the conjugates partially aggregate through PEGMA-PEGMA chain interactions to limit their release rates, whereas conjugates outside of the hydrogel are completely solubilized. Release can therefore be tuned by altering hydrogel components and the PEGMA’s temperature sensitivity without the need for traditional controlled release mechanisms such as particle encapsulation or affinity interactions. Combining local LCST depression technology and degradable zwitterionic hydrogels, complete release of the conjugate was achieved over 13 days.

CHAPTER 8. Integrated Polymer Composites for Electro-responsive Drug Delivery

2018 ◽  
pp. 192-208
Author(s):  
P. Pradeep ◽  
P. Kumar ◽  
Y. E. Choonara ◽  
V. Pillay
Keyword(s):  
Drug Delivery ◽  
Polymer Composites
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