scholarly journals Site-Selective C−S Bond Formation at C−Br over C−OTf and C−Cl Enabled by an Air-Stable, Easily Recoverable, and Recyclable Palladium(I) Catalyst

2018 ◽  
Vol 57 (38) ◽  
pp. 12425-12429 ◽  
Author(s):  
Thomas Scattolin ◽  
Erdem Senol ◽  
Guoyin Yin ◽  
Qianqian Guo ◽  
Franziska Schoenebeck
Keyword(s):  
Bond Formation ◽  
Site Selective

Recent Advances in C–Br Bond Formation

Synlett ◽  
2021 ◽  
Author(s):  
Ying-Yeung Yeung ◽  
Jonathan Wong
Keyword(s):  
Organic Synthesis ◽  
Aromatic Compounds ◽  
Bond Formation ◽  
Cross Coupling ◽  
Catalytic Site ◽  
Atom Transfer ◽  
Bond Forming ◽  
Recent Advances ◽  
Catalytic Asymmetric ◽  
Site Selective

AbstractOrganobromine compounds are extremely useful in organic synthesis. In this perspective, a focused discussion on some recent advancements in C–Br bond-forming reactions is presented.1 Introduction2 Selected Recent Advances2.1 Catalytic Asymmetric Bromopolycyclization of Olefinic Substrates2.2 Catalytic Asymmetric Intermolecular Bromination2.3 Some New Catalysts and Reagents for Bromination2.4 Catalytic Site-Selective Bromination of Aromatic Compounds2.5 sp3 C–H Bromination via Atom Transfer/Cross-Coupling3 Outlook

A Site‐Selective C−N Bond Formation of 2,4‐Dichloro‐5 H ‐pyrano[2,3‐ d ]pyrimidines and Amide

2021 ◽  
Vol 6 (43) ◽  
pp. 12032-12035
Author(s):  
Jinjing Qin ◽  
Zhenhua Li ◽  
Yingyan Cao ◽  
Yuanyuan Xie ◽  
Weike Su
Keyword(s):  
Bond Formation ◽  
A Site ◽  
Site Selective

scholarly journals A general method for site-selective Csp3–S bond formation via cooperative catalysis

2020 ◽  
Vol 11 (5) ◽  
pp. 1276-1282 ◽  
Author(s):  
Yuman Qin ◽  
Yujie Han ◽  
Yongzhen Tang ◽  
Junfa Wei ◽  
Mingyu Yang
Keyword(s):  
Functional Group ◽  
Bond Formation ◽  
Aliphatic Amines ◽  
Cooperative Catalysis ◽  
Site Selective ◽  
General Method

A copper-catalyzed site-selective thiolation of Csp3–H bonds of aliphatic amines was developed. The method features a broad substrate scope and good functional group tolerance.

scholarly journals Cubic Siloxanes with Both Si−H and Si−Ot Bu Groups for Site-Selective Siloxane Bond Formation

2016 ◽  
Vol 22 (39) ◽  
pp. 13737-13737
Author(s):  
Shohei Saito ◽  
Nao Yamasue ◽  
Hiroaki Wada ◽  
Atsushi Shimojima ◽  
Kazuyuki Kuroda
Keyword(s):  
Bond Formation ◽  
Siloxane Bond ◽  
Site Selective

scholarly journals Ring-size-selective construction of fluorine-containing carbocycles via intramolecular iodoarylation of 1,1-difluoro-1-alkenes

2017 ◽  
Vol 13 ◽  
pp. 2682-2689 ◽  
Author(s):  
Takeshi Fujita ◽  
Ryo Kinoshita ◽  
Tsuyoshi Takanohashi ◽  
Naoto Suzuki ◽  
Junji Ichikawa
Keyword(s):  
Bond Formation ◽  
Ring Size ◽  
Carbon Bond ◽  
Iodine Species ◽  
Carbon Carbon Bond ◽  
Site Selective

1,1-Difluoro-1-alkenes bearing a biaryl-2-yl group effectively underwent site-selective intramolecular iodoarylation by the appropriate cationic iodine species. Iodoarylation of 2-(2-aryl-3,3-difluoroallyl)biaryls proceeded via regioselective carbon–carbon bond formation at the carbon atoms in β-position to the fluorine substituents, thereby constructing dibenzo-fused six-membered carbocycles bearing a difluoroiodomethyl group. In contrast, 2-(3,3-difluoroallyl)biaryls underwent a similar cyclization at the α-carbon atoms to afford ring-difluorinated seven-membered carbocycles.

scholarly journals Site-Selective Alkoxylation of Benzylic C–H Bonds via Photoredox Catalysis

2019 ◽  
Author(s):  
Byung Joo Lee ◽  
kimberly deglopper ◽  
Tehshik Yoon
Keyword(s):  
Late Stage ◽  
Functional Group ◽  
Bond Formation ◽  
Bioactive Molecules ◽  
Site Selectivity ◽  
Wide Range ◽  
High Site ◽  
Alkoxy Groups ◽  
Site Selective ◽  
Mediated Oxidation

<div> <div> <div> <p>There are relatively few methods that accom- plish the selective alkoxylation of sp3-hybridized C–H bonds, particularly in comparison to the numerous analogous strate- gies for C–N and C–C bond formation. We report a photo- catalytic protocol for the functionalization of benzylic C–H bonds with a wide range of readily available oxygen nucleo- philes. Our strategy merges the photoredox activation of arenes with copper(II)-mediated oxidation of the resulting benzylic radicals, which enables the introduction of benzylic C–O bonds with high site selectivity, chemoselectivity, and functional group tolerance. This method enables the late- stage introduction of complex alkoxy groups into bioactive molecules, providing a practical new tool with potential appli- cations in synthesis and medicinal chemistry. </p> </div> </div> </div>

scholarly journals Cover Picture: Cubic Siloxanes with Both Si−H and Si−Ot Bu Groups for Site-Selective Siloxane Bond Formation (Chem. Eur. J. 39/2016)

2016 ◽  
Vol 22 (39) ◽  
pp. 13733-13733
Author(s):  
Shohei Saito ◽  
Nao Yamasue ◽  
Hiroaki Wada ◽  
Atsushi Shimojima ◽  
Kazuyuki Kuroda
Keyword(s):  
Bond Formation ◽  
Siloxane Bond ◽  
Site Selective

Rh-Catalyzed C–C/C–N bond formation via C–H activation: synthesis of 2H-indazol-2-yl-benzo[a]carbazoles

2019 ◽  
Vol 6 (23) ◽  
pp. 3885-3890 ◽  
Author(s):  
Sundaravel Vivek Kumar ◽  
Sonbidya Banerjee ◽  
Tharmalingam Punniyamurthy
Keyword(s):  
Ring Opening ◽  
Bond Formation ◽  
Mechanistic Studies ◽  
Site Selective

Rh-Catalyzed site-selective C–H activation and ring opening/cyclization of 7-azabenzonorbornadienes with aryl-2H-indazoles is developed to furnish indazolyl-benzocarbazole frameworks. Substrate scope and mechanistic studies are important practical features.

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