As an alternative to surmount the weakness of
natural enzymes, nanozymes have recently attracted extensive attention from early
disease diagnosis to tumor therapy. However, due to the lack of enzyme-like
molecular recognition units, the poor substrate selectivity of nanozyme-catalyzed
reaction significantly restricts their widespread applications. By biomimicking
the ingenuity of metabolism process in living, herein we report a multiple-nanozymes
system capable of improving the substrate selectivity via cascade reactions in
a confined space. As a showcase, the nitrogen-doped carbon nanocages (NCNC) and
Prussian blue nanoparticles (PB NPs) were successfully coupled in a microfluidic
device to highly selective oxidation and detection of ascorbic acid (AA, an
important electron donor and catalyst for alleviation of oxidative stress) against
other interferences. It was revealed that the products of the prior nanozymatic
reaction were effectively <a></a><a>screened</a> as the reactants of the next
one, thus stepwise improving the overall selectivity of the all-nanozyme
system. This work may open a new door to improve the selectivity of
all-nanozyme-system for prospect applications.
Tumor Therapy: Pd‐Single‐Atom Coordinated Biocatalysts for Chem‐/Sono‐/Photo‐Trimodal Tumor Therapies (Adv. Mater. 29/2021)
