Novel green synthesis of Boswellia serrata leaf aqueous extract conjugated gold nanoparticles with excellent anti‐acute myeloid leukemia property in comparison to mitoxantrone in a leukemic mice model: Introducing a new chemotherapeutic drug

2019 ◽  
Vol 34 (3) ◽  
Author(s):  
Ahmad Ahmeda ◽  
Mohammad Mahdi Zangeneh
Keyword(s):  
Gold Nanoparticles ◽  
Acute Myeloid Leukemia ◽  
Green Synthesis ◽  
Aqueous Extract ◽  
Myeloid Leukemia ◽  
Chemotherapeutic Drug ◽  
Mice Model ◽  
Boswellia Serrata ◽  
Leaf Aqueous Extract ◽  
Acute Myeloid

scholarly journals Formulation a modern chemotherapeutic drug of Ziziphora clinopodides Lam leaf aqueous extract conjugated cadmium nanoparticles and analysis of their anti-acute myeloid leukemia potentials in comparison to Daunorubicin in leukemic mouse and cellular models: Antidiabetic and Anticholinergics Potentials

2020 ◽  
Author(s):  
Behnam Mahdavi ◽  
Mohammad Mahdi Zangeneh ◽  
Sogand Paydarfar ◽  
Esmaeil Rezaeiseresht ◽  
Akram Zangeneh ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Cell Lines ◽  
Aqueous Extract ◽  
Myeloid Leukemia ◽  
Chemotherapeutic Drug ◽  
X Ray ◽  
Cellular Models ◽  
Leaf Aqueous Extract ◽  
Vis Spectroscopy ◽  
Acute Myeloid

Abstract In this study, the anti-acute myeloid leukemia (AML) effects of Ziziphora clinopodioides Lam leaf aqueous extract conjugated cadmium nanoparticles (CdNPs) were compared with daunorubicin as a common chemotherapeutic drug. To synthesize CdNPs, Z. clinopodioides aqueous extract was combined with Cd(NO 3 ) 2 .4H 2 O. For analyzing CdNPs, SEM, UV-Vis. spectroscopy, X-ray powder diffraction and Energy dispersing X-ray spectroscopy, Fourier Transform Infrared techniques were used. In FE-SEM images of CdNPs, the diameter of particle dimension was on means of 26.78 nm. To survey the cytotoxicity and anti-AML effects of Cd(NO 3 ) 2 , Z. clinopodioides, Daunorubicin, CdNPs and MTT assay was used on the human AML cell lines. The IC50 of the cadmium nanoparticles was 168, 205 and 210 µg/mL against Murine C1498, 32D/FLT3-ITD and Human HL-60/vcr cell lines, respectively. In vivo study, CdNPs like daunorubicin ameliorated importantly (P≤0.01) the biochemical, WBC, RBC, inflammatory, platelet, stereological, histopathological and cellular-molecular parameters compared to the other groups. As mentioned, the cadmium nanoparticles had significant anti-AML effects. After approving the above eventuate in the clinical trial studies, these cadmium nanoparticles could be used in humans as a chemotherapeutic medicament for the treatment of AML. Additionally, the novel nanoparticles (Cd(NO 3 ) 2 and CdNPs) were good inhibitors of the α-glycosidase, and cholinesterase enzymes.

scholarly journals Gold nanoparticles enhance the effect of tyrosine kinase inhibitors in acute myeloid leukemia therapy

2016 ◽  
pp. 641 ◽  
Author(s):  
Ciprian Tomuleasa ◽  
Bobe Petrushev ◽  
Sanda Boca ◽  
Timea Simon ◽  
Cristian Berce ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Acute Myeloid Leukemia ◽  
Tyrosine Kinase ◽  
Tyrosine Kinase Inhibitors ◽  
Myeloid Leukemia ◽  
Kinase Inhibitors ◽  
Acute Myeloid

scholarly journals Anti-leukemia properties of cadmium nanoparticles in the in vitro and in vivo condition: A chemobiological study

2021 ◽  
Author(s):  
Yudi Miao ◽  
Behnam Mahdavi ◽  
Mohammad Zangeneh
Keyword(s):  
Acute Myeloid Leukemia ◽  
Cell Lines ◽  
Aqueous Extract ◽  
Myeloid Leukemia ◽  
Antioxidant Properties ◽  
Leukemia Cell ◽  
Sem Images ◽  
Acute Myeloid

IntroductionThe present study investigated the anti-acute myeloid leukemia effects of Ziziphora clinopodides Lam leaf aqueous extract conjugated cadmium nanoparticles.Material and methodsTo synthesize CdNPs, Z. clinopodides aqueous extract was mixed with Cd(NO3)2 .4H2O. The characterization of the biosynthesized cadmium nanoparticles was carried out using many various techniques such as UV-Vis. and FT-IR spectroscopy, XRD, FE-SEM, and EDS.ResultsThe uniform spherical morphology of NPs was proved by FE-SEM images with NPs the average size of 26.78cnm. For investigating the antioxidant properties of Cd(NO3)2, Z. clinopodides, CdNPs, and Daunorubicin, the DPPH test was used. The cadmium nanoparticles inhibited half of the DPPH molecules in a concentration of 196 µg/mL. To survey the cytotoxicity and anti-acute myeloid leukemia effects of Cd(NO3)2, Z. clinopodides, CdNPs, and Daunorubicin, MTT assay was used on the human acute myeloid leukemia cell lines i.e., Murine C1498, 32D-FLT3-ITD, and Human HL-60/vcr. The IC50 of the cadmium nanoparticles was 168, 205, and 210 µg/mL against Murine C1498, 32D-FLT3-ITD, and Human HL-60/vcr cell lines, respectively. In the part of in vivo study, DMBA was used for inducing acute myeloid leukemia in mice. CdNPs similar to daunorubicin ameliorated significantly (p≤0.01) the biochemical, inflammatory, RBC, WBC, platelet, stereological, histopathological, and cellular-molecular parameters compared to the other groups.ConclusionsAs mentioned, the cadmium nanoparticles had significant anti-acute myeloid leukemia effects. After approving the above results in the clinical trial studies, these cadmium nanoparticles can be used as a chemotherapeutic drug to treat acute myeloid leukemia in humans.

Gelatin-coated Gold Nanoparticles as Carriers of FLT3 Inhibitors for Acute Myeloid Leukemia Treatment

2016 ◽  
Vol 87 (6) ◽  
pp. 927-935 ◽  
Author(s):  
Sorina Suarasan ◽  
Timea Simon ◽  
Sanda Boca ◽  
Ciprian Tomuleasa ◽  
Simion Astilean
Keyword(s):  
Gold Nanoparticles ◽  
Acute Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Flt3 Inhibitors ◽  
Leukemia Treatment ◽  
Acute Myeloid
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