Ferrocenylmethylation of estrone and estradiol: Structure, electrochemistry, and antiproliferative activity of new ferrocene–steroid conjugates

2020 ◽  
Vol 34 (10) ◽  
Author(s):  
Vidak Raičević ◽  
Niko Radulović ◽  
Ljiljana Jovanović ◽  
Marko Rodić ◽  
Ivana Kuzminac ◽  
...  
Keyword(s):  
Antiproliferative Activity ◽  
Steroid Conjugates

Water soluble palladium(ii) and platinum(ii) acyclic diaminocarbene complexes: solution behavior, DNA binding, and antiproliferative activity

2020 ◽  
Vol 44 (15) ◽  
pp. 5762-5773 ◽  
Author(s):  
Tatiyana V. Serebryanskaya ◽  
Mikhail A. Kinzhalov ◽  
Vladimir Bakulev ◽  
Georgii Alekseev ◽  
Anastasiya Andreeva ◽  
...  
Keyword(s):  
Dna Binding ◽  
Antiproliferative Activity ◽  
Water Soluble ◽  
Solution Behavior ◽  
Antitumor Potential ◽  
Acyclic Diaminocarbene

Water soluble Pd(ii) and Pt(ii)–ADC species synthesized via the metal-mediated coupling of isocyanides and 1,2-diaminobenzene have demonstrated antitumor potential.

Antiproliferative activity of ent-abietane lactones against resistant human cancer cell lines

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
N Duarte ◽  
H Lage ◽  
MJU Ferreira
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Antiproliferative Activity ◽  
Human Cancer ◽  
Cancer Cell Lines ◽  
Human Cancer Cell ◽  
Human Cancer Cell Lines

In vitro and in vivo antiproliferative activity of arucanolide isolated from Calea pinnatifida

Planta Medica ◽  
2010 ◽  
Vol 76 (12) ◽  
Author(s):  
G Marchetti ◽  
K Silva ◽  
A Ruiz ◽  
I Sousa ◽  
S Tinti ◽  
...  
Keyword(s):  
Antiproliferative Activity

Trigona laeviceps propolis: Chemical compositions and antiproliferative activity on cancer cell lines

Planta Medica ◽  
2011 ◽  
Vol 77 (12) ◽  
Author(s):  
C Chanchao ◽  
S Umthong ◽  
P Phuwapraisirisan ◽  
S Puthong
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Antiproliferative Activity ◽  
Cancer Cell Lines ◽  
Chemical Compositions

Selective antiproliferative activity of spinasterol from Physospemum verticillatum against A549 and COR-L23 cancer cells

Planta Medica ◽  
2012 ◽  
Vol 78 (11) ◽  
Author(s):  
R Tundis ◽  
B Deguin ◽  
MR Loizzo ◽  
M Bonesi ◽  
S Michel ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Antiproliferative Activity

Sesquiterpenes from Neurolaena lobata with antiproliferative activity

2017 ◽  
Author(s):  
A Vasas ◽  
I Lajter ◽  
P Forgó ◽  
N Kúsz ◽  
N Bózsity ◽  
...  
Keyword(s):  
Antiproliferative Activity

METABOLISM OF PREGNENOLONE-3-SULPHATE IN THE PERFUSED DOG LIVER

1965 ◽  
Vol 49 (3) ◽  
pp. 427-435 ◽  
Author(s):  
K. D. Voigt ◽  
J. Tamm ◽  
U. Volkwein ◽  
H. Schedewie
Keyword(s):  
Metabolic Pathways ◽  
Dog Liver ◽  
Steroid Conjugates

ABSTRACT Pregnenolone-sulphate (400 mg) was perfused through isolated dog livers. The following steroids were isolated in the perfusate: pregnenolone, progesterone, dehydroepiandrosterone, androst-5-ene-diol and the two steroid conjugates, i. e. pregnenolone-sulphate and dehydroepiandrosterone-sulphate. Two »free« steroids and one steroid conjugate could not be characterized. A tentative scheme for the metabolic pathways of pregnenolone-sulphate is presented.

Synthesis, Characterization and Antiproliferative Activity Assessment of a Novel 1H-5-mercapto-1,2,4 Triazole Derivative

2017 ◽  
Vol 68 (4) ◽  
pp. 745-747 ◽  
Author(s):  
Marius Mioc ◽  
Sorin Avram ◽  
Vasile Bercean ◽  
Mihaela Balan Porcarasu ◽  
Codruta Soica ◽  
...  
Keyword(s):  
Antiproliferative Activity ◽  
Biological Activities ◽  
Cancer Cell Line ◽  
Vascular Endothelial ◽  
Triazole Derivative ◽  
Activity Assessment ◽  
Wide Range ◽  
Specific Receptors ◽  
Endothelial Growth Factor ◽  
Selection Of

Angiogenesis plays an important function in tumor proliferation, one of the main angiogenic promoters being the vascular endothelial growth factor (VEGF) which activates specific receptors, particularly VEGFR-2. Thus, VEGFR-2 has become an essential therapeutic target in the development of new antitumor drugs. 1,2,4-triazoles show a wide range of biological activities, including antitumor effect, which was documented by numerous reports. In the current study the selection of 5-mercapto-1,2,4-triazole structure (1H-3-styryl-5-benzylidenehydrazino-carbonyl-methylsulfanil-1,2,4-triazole, Tz3a.7) was conducted based on molecular docking that emphasized it as suitable ligand for VEGFR-2 and EGFR1 receptors. Compound Tz3a.7 was synthesized and physicochemically and biologically evaluated thus revealing a moderate antiproliferative activity against breast cancer cell line MDA-MB-231.

Changes in Phytochemical Content and Antiproliferative Activity of Germinated Geunnun and Ilpum Rice Varieties

2013 ◽  
Vol 42 (7) ◽  
pp. 1157-1161 ◽  
Author(s):  
Jeehye Sung ◽  
Junsoo Lee ◽  
Sea-Kwan Oh ◽  
Jeom-Sig Lee ◽  
Won-Seok Choi
Keyword(s):  
Antiproliferative Activity ◽  
Rice Varieties ◽  
Phytochemical Content

3D-QSAR, Virtual Screening, Docking and Design of Dual PI3K/mTOR Inhibitors with Enhanced Antiproliferative Activity

2017 ◽  
Vol 20 (4) ◽  
Author(s):  
Jelena Oluić ◽  
Katarina Nikolic ◽  
Jelica Vucicevic ◽  
Zarko Gagic ◽  
Slavica Filipic ◽  
...  
Keyword(s):  
Virtual Screening ◽  
Antiproliferative Activity ◽  
Mtor Inhibitors ◽  
3D Qsar
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