Efficient One Pot Synthesis of Phenylimidazo[1,2‐ a ]pyridine Derivatives using Multifunctional Copper Catalyst Supported on β‐Cyclodextrin Functionalized Magnetic Graphene oxide

2020 ◽  
Vol 34 (11) ◽  
Author(s):  
Saeed Bahadorikhalili ◽  
Khodadad Malek ◽  
Mohammad Mahdavi
Keyword(s):  
Graphene Oxide ◽  
Copper Catalyst ◽  
Pyridine Derivatives ◽  
One Pot ◽  
Magnetic Graphene Oxide ◽  
One Pot Synthesis ◽  
Magnetic Graphene

scholarly journals Cysteic acid grafted to magnetic graphene oxide as a promising recoverable solid acid catalyst for the synthesis of diverse 4H-chromene

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Firouz Matloubi Moghaddam ◽  
Mohammad Eslami ◽  
Golfamsadat Hoda
Keyword(s):  
Graphene Oxide ◽  
Solid Acid ◽  
Solid Acid Catalyst ◽  
Acid Catalyst ◽  
Cysteic Acid ◽  
One Pot ◽  
Magnetic Graphene Oxide ◽  
Magnetic Graphene ◽  
Synthesis Methodology ◽  
Short Time

Abstract4H-chromenes play a significant role in natural and pharmacological products. Despite continuous advances in the synthesis methodology of these compounds, there is still a lack of a green and efficient method. In this study, we have designed cysteic acid chemically attached to magnetic graphene oxide (MNPs·GO-CysA) as an efficient and reusable solid acid catalyst to synthesize 4H-chromene skeletons via a one-pot three components reaction of an enolizable compound, malononitrile, an aldehyde or isatin, and a mixture of water–ethanol as a green solvent. This new heterogeneous catalyst provides desired products with a good to excellent yield, short time, and mild condition. This procedure presents an environmentally friendly approach for the synthesis of a great number of 4H-chromene derivatives.

Enhanced adsorption of malathion and phoxim by a three-dimensional magnetic graphene oxide-functionalized citrus peel-derived bio-composite

2021 ◽  
Author(s):  
Shurui Cao ◽  
Yue Zhou ◽  
Cunxian Xi ◽  
Tiantian Tang ◽  
Zhiqiong Chen
Keyword(s):  
Graphene Oxide ◽  
Three Dimensional ◽  
One Pot ◽  
Citrus Peel ◽  
Magnetic Graphene Oxide ◽  
Magnetic Graphene ◽  
Enhanced Adsorption

Integrating the steps of direct magnetization and one-pot pyrolysis, a three-dimensional (3D) magnetic graphene oxide-functionalized citrus peel-derived bio-composite (mGOBC) was synthesized and characterized successfully, which was proved to possess three-dimensional...

Development of A Novel System Based on Green Magnetic / Graphene Oxide / Chitosan /Allium Sativum / Quercus / Nanocomposite for Targeted Release of Doxorubicin Anti-Cancer Drug

2020 ◽  
Vol 20 (9) ◽  
pp. 1094-1104 ◽  
Author(s):  
Omid Arjmand ◽  
Mehdi Ardjmand ◽  
Ali M. Amani ◽  
Mohmmad H. Eikani
Keyword(s):  
Graphene Oxide ◽  
Allium Sativum ◽  
Cytotoxicity Assay ◽  
Targeted Treatment ◽  
Cancer Drug ◽  
Magnetic Graphene Oxide ◽  
Magnetic Graphene ◽  
Anti Cancer ◽  
Cancerous Cells ◽  
Targeted Release

Background: Doxorubicin, as a strong anti-cancer agent for clinical treatment of various cancer types along with other drugs, is widely utilized. Due to the physiology of the human body and cancerous tissues, the applicability of doxorubicin is still limited and the targeted treatment of the different types of cancers is considered. Also, the side effects of the conventional forms of chemotherapy medicines, damaging and stressing the normal cells are considerable. Objective: This study introduces a novel and effective system for the targeted release of doxorubicin by successfully fabricating the green magnetic graphene oxide, chitosan, allium sativum, and quercus nanocomposite. Methods: The in vitro release of doxorubicin loaded on the nanocomposite was evaluated and investigated at pH 7.4 and 6.5, respectively. The drug diffusivity in the plasma environment was assessed for a more accurate analysis of the drug diffusion process. The nanocomposite loaded drug release mechanism and kinetics, as well as cytotoxicity assay was investigated. Results: The efficiency of the drug encapsulation was significantly enhanced using natural extract ingredients and consequently, the efficacy of the targeted treatment of cancerous tissues was improved. The developed nanocomposite provided a controlled release of doxorubicin in similar acidic conditions of the normal and cancerous cells and affirming that the fabricated system is thoroughly pH-dependent. Conclusion: The cytotoxicity assay confirmed that the fabricated nanocomposite at a high growth rate of cancerous cells has an anticancer property and acts as a toxic agent against tumor cells, suggesting that in conjunction with doxorubicin, it can be highly improved for killing cancerous cells.

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