Ruthenium, rhodium, and iridium complexes featuring coumarin hydrazone derivatives: Synthesis, characterization, and preliminary investigation of their anticancer and antibacterial activity

2022 ◽  
Author(s):  
Lincoln Dkhar ◽  
Akalesh Kumar Verma ◽  
Venkanna Banothu ◽  
Werner Kaminsky ◽  
Mohan Rao Kollipara
Keyword(s):  
Antibacterial Activity ◽  
Preliminary Investigation ◽  
Iridium Complexes

Half-sandwich ruthenium, rhodium and iridium complexes featuring oxime ligands: Structural studies and preliminary investigation of in vitro and in vivo anti-tumour activities

2016 ◽  
Vol 31 (7) ◽  
pp. e3640 ◽  
Author(s):  
Narasinga Rao Palepu ◽  
Sanjay Adhikari ◽  
Richard Premkumar J ◽  
Akalesh K. Verma ◽  
Samantha L. Shepherd ◽  
...  
Keyword(s):  
Preliminary Investigation ◽  
Iridium Complexes ◽  
Structural Studies ◽  
Half Sandwich

Preliminary Investigation of the Antibacterial Activity of Psidium guajava Extracts

2015 ◽  
Vol 7 (1) ◽  
pp. 26-30 ◽  
Author(s):  
Iroha Ifeanyichukwu ◽  
Ejikeugwu Chika ◽  
Nwakaeze Emmanuel ◽  
Oji Anthonia ◽  
Afiukwa Ngozi ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Preliminary Investigation ◽  
Psidium Guajava

scholarly journals A Preliminary Investigation on the In-Vitro Antibacterial Activities of Cave Actinomycetes

2021 ◽  
Vol 16 (3) ◽  
Author(s):  
Asifa Mushtaq ◽  
Musharaf Gul ◽  
Seema Rawat ◽  
Jay Krishan Tiwari
Keyword(s):  
Antibacterial Activity ◽  
Secondary Metabolites ◽  
Scientific Community ◽  
Preliminary Investigation ◽  
Antibacterial Properties ◽  
Antibacterial Activities ◽  
Industrial Applications ◽  
Gram Positive Bacteria ◽  
Streptomyces Genus

Actinomycetes are prolific producers of secondary metabolites majority of which have phenomenal industrial applications. Actinomycetes recovered from cave habitats have generated a considerable interest among the scientific community with respect to their adaptability under such unique environmental conditions. Garhwal Himalaya, Uttarakhand abodes several pristine caves which have not been previously explored for the presence of actinomycetes. The present study has been undertaken to assess the in vitro antibacterial properties of actinomycetes recovered from some of the caves located in Garhwal Himalayan region. In the present study, a total of 127 actinomycetes were isolated from three distinct caves. Majority of the isolates exhibited antibacterial activity against gram-positive bacteria. Actinomycetes isolates RCM1 and SCMM1 were observed to evince promising antibacterial activities. Members of Streptomyces genus were found to be predominant in all the samples.

scholarly journals Preliminary Investigation of the Antibacterial Activity of Antitumor Drug 3-Amino-1,2,4-Benzotriazine-1,4-Dioxide (Tirapazamine) and its Derivatives

2020 ◽  
Vol 10 (12) ◽  
pp. 4062 ◽  
Author(s):  
Evelina Polmickaitė-Smirnova ◽  
Jonas Šarlauskas ◽  
Kastis Krikštopaitis ◽  
Živilė Lukšienė ◽  
Zita Staniulytė ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Density Functional ◽  
Preliminary Investigation ◽  
Structural Features ◽  
Antitumor Drug ◽  
Additive Effects ◽  
Bacterial Strains ◽  
Functional Theory ◽  
Inhibitory Activities

The antitumor drug 3-amino-1,2,4-benzotriazine-1,4-dioxide (tirapazamine, TPZ (1)) along with a number of newly synthesized tirapazamine derivatives (TPZs) bearing substitutions at the 3-amine position of TPZ (1) were estimated for their antibacterial activity against representative Gram-negative Escherichia coli (ATCC 25922) and Salmonella enterica (SL 5676), as well as Gram-positive Staphylococcus aureus (ATCC 25923) bacterial strains. Their activities in terms of minimum inhibitory concentrations (MICs) varied in the range of 1.1 µM (0.25 µg/mL)–413 µM (128 µg/mL). Amongst the most potent derivatives (1–6), acetyl- and methoxycarbonyl-substituted TPZs (2 and 4) were the strongest agents, which exhibited approximately 4–30 fold greater activities compared to those of TPZ (1) along with the reference drugs chloramphenicol (CAM) and nitrofurantoin (NFT). The inhibitory activities of the compounds were highly impacted by their structural features. No reliable relationships were established between activities and the electron-accepting potencies of the whole set of studied compounds, while the activities of TPZ drug (1) and the structurally uniform set of molecules (2–6) were found to increase with an increase in their electron-accepting potencies obtained by means of density functional theory (DFT) computation. A greater steric, lipophilic and polar nature of the substituents led to a lower activity of the compounds. The combined antibacterial in vitro trial gave clear evidence that TPZs coupled with the commonly utilized antibiotics ciprofloxacin (Cipro) and nitrofurantoin (NFT) could generate enhanced (suggestive of partial and virtually complete synergistic) and additive effects. The strongest effects were defined for TPZs–NFT combinations, which resulted in a notable reduction in the MICs of di-N-oxides. These preliminary findings suggest that the synthesized novel di-N-oxides might be used as sole agents or applied as antibiotic complements.

Preliminary investigation of antimicrobial activity of the skin secretions of frogs from Bangladesh

2019 ◽  
Vol 40 (4) ◽  
pp. 531-536
Author(s):  
Md. Sirajul Islam ◽  
Md. Mokhlesur Rahman ◽  
Md. Mizanur Rahaman
Keyword(s):  
Antimicrobial Activity ◽  
Antibacterial Activity ◽  
Preliminary Investigation ◽  
Gram Negative Bacteria ◽  
Gram Positive ◽  
Gram Negative ◽  
Gram Positive Bacteria ◽  
Hoplobatrachus Tigerinus ◽  
Skin Secretions ◽  
Polypedates Leucomystax

Abstract Amphibians, like some animals and plants, defend themselves against various pathogenic organisms by producing and secreting various peptides and small molecules from granular skin glands. In this study, we evaluated for the first time, the antibiotic activity of the skin secretions of 8 different frog species (Euphlyctis cyanophlyctis, E. hexadactylus, Fejervarya teraiensis, F. asmati, F. syhadrensis, Hoplobatrachus tigerinus, Microhyla ornata and Polypedates leucomystax) from Bangladesh. These secretions were collected by a nonlethal approach through chemical stimulation and the antibacterial activity was evaluated by broth macrodilution method against some Gram-positive and Gram-negative bacteria. Our study revealed that all the skin secretions (8 out of 8) from the selected frogs have antimicrobial activity against Gram-positive bacteria and 7 out of 8 skin secretions possess antibacterial activity against Gram-negative bacteria tested. Further analysis of data showed that these secretions are significantly more effective against Gram-positive bacteria than Gram-negative bacteria.

scholarly journals Preliminary investigation on the antibacterial activity of mango (Mangifera indica L: Anacardiaceae) seed kernel

2010 ◽  
Vol 3 (9) ◽  
pp. 707-710 ◽  
Author(s):  
Jasminder Kaur ◽  
Xavier Rathinam ◽  
Marimuthu Kasi ◽  
Khoo Miew Leng ◽  
Rajasekaran Ayyalu ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Mangifera Indica ◽  
Preliminary Investigation ◽  
Seed Kernel

scholarly journals Synthesis and Biological Evaluation of 7-O-Modified Formononetin Derivatives

2008 ◽  
Vol 2008 ◽  
pp. 1-4 ◽  
Author(s):  
Ying Yang ◽  
Wen-Jun Mao ◽  
Huan-Qiu Li ◽  
Tao-Tao Zhu ◽  
Lei Shi ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Cell Line ◽  
Jurkat Cell ◽  
Preliminary Investigation ◽  
Biological Evaluation ◽  
Bacterial Strains ◽  
Chemical Structures ◽  
Structure Activity ◽  
Synthesis And Biological Evaluation ◽  
Antiproliferative Activities

Three series of novel formononetin derivatives were synthesized, in which formononetin and heterocyclic moieties were separated by 2-carbon, 3-carbon, and 4-carbon spacers. The chemical structures of these compounds were confirmed. All the derivatives were screened for antiproliferative activities against Jurkat cell line and HepG-2 cell line. In this paper, compounds prepared were also screened for their antibacterial activity of six bacterial strains. Compound 3b exihibited promising antibacterial activity against B. subtilis with minimal inhibitory concentration (MIC) value of 0.78 μg/mL, and compound 5e showed significant antiproliferative activities against Jurkat cell growth with IC50 of 1.35×10−4 μg/mL. The preliminary investigation of structure-activity relationships (SARs) was also discussed based on the obtained experimental data.

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