scholarly journals Contribution of Mast Cell-Derived Interleukin-1β to Uric Acid Crystal-Induced Acute Arthritis in Mice

2014 ◽  
Vol 66 (10) ◽  
pp. 2881-2891 ◽  
Author(s):  
Laurent L. Reber ◽  
Thomas Marichal ◽  
Jeremy Sokolove ◽  
Philipp Starkl ◽  
Nicolas Gaudenzio ◽  
...  
Keyword(s):  
Mast Cell ◽  
Uric Acid ◽  
Interleukin 1Β ◽  
Uric Acid Crystal ◽  
Acute Arthritis ◽  
Acid Crystal

An in Situ Atomic Force Microscopy Study of Uric Acid Crystal Growth

2005 ◽  
Vol 109 (20) ◽  
pp. 9989-9995 ◽  
Author(s):  
Ryan E. Sours ◽  
Amanuel Z. Zellelow ◽  
Jennifer A. Swift
Keyword(s):  
Atomic Force Microscopy ◽  
Uric Acid ◽  
Crystal Growth ◽  
Microscopy Study ◽  
Atomic Force Microscopy Study ◽  
Uric Acid Crystal ◽  
Force Microscopy ◽  
Acid Crystal ◽  
Atomic Force

scholarly journals Gout - asymptomatic hyperuricemia with/without asymptomatic monosodium urate crystal deposition: To be treated or not?

2019 ◽  
Vol 147 (11-12) ◽  
pp. 777-781
Author(s):  
Marija Radak-Perovic ◽  
Mirjana Zlatkovic-Svenda
Keyword(s):  
Uric Acid ◽  
Imaging Techniques ◽  
Serum Uric Acid Level ◽  
Tumor Lysis Syndrome ◽  
Chronic Inflammatory Disease ◽  
Low Grade ◽  
Crystal Deposition ◽  
Uric Acid Crystal ◽  
Acid Crystal ◽  
Xanthine Oxidase Inhibitors

Elevation of serum uric acid level without clinically visible arthritis (known as asymptomatic hyperuricemia) is not traditionally considered to be gout disease, but only a possible cause of it, even though it may be accompanied by tissue uric acid crystal deposition. On the other hand, gout is traditionally recognized as recurrent, overt arthritis, visible only after a long period of time due to uric acid accumulation in joints. Advanced imaging techniques have substantially changed the perception of this problem, identifying gout as a low-grade chronic inflammatory disease from the very beginning, visible only by phases of acute arthritis attacks. According to ultrasonography, uric acid crystal hyperechoic aggregates (tophi) are seen not only in the symptomatic gout disease phase, but also in the preceding ? asymptomatic (latent) ? gout phase. New perception of the problem was approved by the recently described NETs (neutrophil extracellular traps) phenomenon. Also, hyperuricemia has recently been identified as a systemic disorder, responsible not only for the apparent gout arthritis, but also for the renal and cardiovascular disease occurrence and progression. Positive effect of urate-lowering therapy (xanthine oxidase inhibitors and uricosurics) on hypertension and chronic kidney disease indicates a possibility of its utility in asymptomatic hyperuricemia and asymptomatic gout therapy, apart from the use in clinically manifested gout treatment and for certain conditions, such as tumor lysis syndrome.

scholarly journals P2772A novel approach for uric acid crystal detection in human coronary arteries with polarization-sensitive micro-OCT

2018 ◽  
Vol 39 (suppl_1) ◽  
Author(s):  
K Nishimiya ◽  
G Sharma ◽  
K Singh ◽  
H Osman ◽  
J A Gardecki ◽  
...  
Keyword(s):  
Uric Acid ◽  
Coronary Arteries ◽  
Uric Acid Crystal ◽  
Acid Crystal ◽  
Novel Approach

The crystal arthropathies

2011 ◽  
pp. 269-280
Author(s):  
Alan J. Hakim ◽  
Gavin P.R. Clunie ◽  
Inam Haq
Keyword(s):  
Uric Acid ◽  
Calcium Phosphate ◽  
Calcium Oxalate ◽  
Calcium Pyrophosphate ◽  
Calcium Pyrophosphate Dihydrate ◽  
Basic Calcium Phosphate ◽  
Uric Acid Crystal ◽  
Acid Crystal ◽  
Crystal Arthropathies ◽  
Uric Acid Nephrolithiasis

Gout and hyperuricaemia 270 Calcium pyrophosphate dihydrate disease 276 Basic calcium phosphate associated disease 279 Calcium oxalate arthritis 280 The crystal arthropathies include gout, calcium pyrophosphate deposition disease (CPPD) or pseudogout, basic calcium phosphate (BCP) associated syndromes, and calcium oxalate arthritis. • In its most general sense, gout is a group of conditions characterized by hyperuricaemia and uric acid crystal formation. These clinical conditions include arthritis, tophaceous gout, uric acid nephrolithiasis, and gouty nephropathy. In its more commonly assumed definition, gout refers to the acute inflammatory arthropathy caused by uric acid crystal deposition....

scholarly journals Complement C5a potentiates uric acid crystal-induced IL-1β production

2014 ◽  
Vol 44 (12) ◽  
pp. 3669-3679 ◽  
Author(s):  
Ling-Ling An ◽  
Payal Mehta ◽  
Linda Xu ◽  
Sean Turman ◽  
Thornik Reimer ◽  
...  
Keyword(s):  
Uric Acid ◽  
Uric Acid Crystal ◽  
Acid Crystal ◽  
Complement C5a

Adhesion Properties of Uric Acid Crystal Surfaces

Langmuir ◽  
2012 ◽  
Vol 28 (19) ◽  
pp. 7401-7406 ◽  
Author(s):  
Janeth B. Presores ◽  
Jennifer A. Swift
Keyword(s):  
Uric Acid ◽  
Crystal Surfaces ◽  
Uric Acid Crystal ◽  
Adhesion Properties ◽  
Acid Crystal

scholarly journals The tyrosine kinase inhibitor imatinib mesylate suppresses uric acid crystal-induced acute gouty arthritis in mice

PLoS ONE ◽  
2017 ◽  
Vol 12 (10) ◽  
pp. e0185704 ◽  
Author(s):  
Laurent L. Reber ◽  
Philipp Starkl ◽  
Bianca Balbino ◽  
Riccardo Sibilano ◽  
Nicolas Gaudenzio ◽  
...  
Keyword(s):  
Uric Acid ◽  
Tyrosine Kinase ◽  
Tyrosine Kinase Inhibitor ◽  
Imatinib Mesylate ◽  
Kinase Inhibitor ◽  
Gouty Arthritis ◽  
Uric Acid Crystal ◽  
Acute Gouty Arthritis ◽  
Acid Crystal

Review of the ophthalmic manifestations of gout and uric acid crystal deposition

2016 ◽  
Vol 45 (1) ◽  
pp. 73-80 ◽  
Author(s):  
Jack Ao ◽  
Fiona Goldblatt ◽  
Robert J Casson
Keyword(s):  
Uric Acid ◽  
Crystal Deposition ◽  
Uric Acid Crystal ◽  
Acid Crystal ◽  
Ophthalmic Manifestations

Uric acid crystal-induced nephropathy: Evidence for a specific renal lesion in a gouty family

1981 ◽  
Vol 135 (2) ◽  
pp. 159-168 ◽  
Author(s):  
D. A. Farebrother ◽  
J. R. Pincott ◽  
H. A. Simmons ◽  
D. J. Warren ◽  
M. J. Dillon ◽  
...  
Keyword(s):  
Uric Acid ◽  
Renal Lesion ◽  
Uric Acid Crystal ◽  
Acid Crystal
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