scholarly journals Increased Risk of Autism Spectrum Disorders in Children Born to Women With Systemic Lupus Erythematosus: Results From a Large Population-Based Cohort

2015 ◽  
Vol 67 (12) ◽  
pp. 3201-3208 ◽  
Author(s):  
Évelyne Vinet ◽  
Christian A. Pineau ◽  
Ann E. Clarke ◽  
Susan Scott ◽  
Éric Fombonne ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Autism Spectrum Disorders ◽  
Lupus Erythematosus ◽  
Large Population ◽  
Population Based ◽  
Autism Spectrum ◽  
Systemic Lupus ◽  
Increased Risk ◽  
Spectrum Disorders

Scurvy mimicking as systemic lupus erythematosus

2021 ◽  
Vol 14 (6) ◽  
pp. e242958
Author(s):  
Narueporn Likhitweerawong ◽  
Nonglak Boonchooduang ◽  
Wipawee Morakote ◽  
Orawan Louthrenoo
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Vitamin C ◽  
Dietary Intake ◽  
Lupus Erythematosus ◽  
Delayed Diagnosis ◽  
Paediatric Population ◽  
Autism Spectrum ◽  
Systemic Lupus ◽  
Vitamin C Deficiency ◽  
Spectrum Disorders

Scurvy is a disease caused by chronic vitamin C deficiency. The greater prevalence was found in the paediatric population with neurodevelopmental disorders such as autism spectrum disorders due to their restricted dietary intake. Our case reported a child with autism who presented with arthralgia and anaemia. Systemic lupus erythematosus was the first diagnostic impression, resulting in over investigation and delayed diagnosis of vitamin C deficiency. After the child was treated with ascorbic acid, the child’s symptoms resolved. This case highlighted the importance of developmental and nutritional history taking in the paediatric population. Furthermore, parents and physicians should be concerned about nutritional status, especially in children with restrictive dietary intake.

scholarly journals Increased Risk for Substance Use-Related Problems in Autism Spectrum Disorders: A Population-Based Cohort Study

2016 ◽  
Vol 47 (1) ◽  
pp. 80-89 ◽  
Author(s):  
Agnieszka Butwicka ◽  
Niklas Långström ◽  
Henrik Larsson ◽  
Sebastian Lundström ◽  
Eva Serlachius ◽  
...  
Keyword(s):  
Substance Use ◽  
Cohort Study ◽  
Autism Spectrum Disorders ◽  
Population Based ◽  
Autism Spectrum ◽  
Increased Risk ◽  
Spectrum Disorders

Autoantibodies persist in relatives to systemic lupus erythematosus patients during 12 years follow-up

Lupus ◽  
2016 ◽  
Vol 26 (7) ◽  
pp. 723-728 ◽  
Author(s):  
H Langkilde ◽  
A Voss ◽  
N Heegaard ◽  
H Laustrup
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Autoimmune Disease ◽  
Autoimmune Diseases ◽  
Lupus Erythematosus ◽  
Population Based ◽  
Systemic Lupus ◽  
Autoantibody Production ◽  
Increased Risk ◽  
Reported Health

Background Systemic lupus erythematosus (SLE) is an autoimmune disease with presence of autoantibodies and characteristic multi-organ involvement. Relatives of SLE patients have an increased risk of autoantibody production and autoimmune diseases. Methods In 2001, 226 first degree relatives (FDRs) of a population-based cohort of SLE patients were examined for the prevalence of autoantibodies and self-reported health complaints. In 2013, 143 FDRs were re-investigated and deceased’s medical records were examined. Results Participants and non-participants were comparable regarding baseline characteristics, while deceased FDRs were older than participants, but with comparable ANA status. ANA status at baseline correlated to ANA status at follow-up. At follow-up, two FDRs reported SLE and 15 FDRs other autoimmune diseases. No observation at baseline alone could predict self-reported health. During follow-up 33 died at median age 76 years. Three deceased FDRs were diagnosed with an autoimmune disease. Conclusion The study showed that FDRs of SLE patients have an increased prevalence of ANA compared to healthy controls. The prevalence increased during follow-up, and ANA positive FDRs at baseline were prone to be ANA positive at follow-up. ANA positive FDRs had more self-reported autoimmune diseases, including SLE and rheumatoid arthritis, than reported from other population-based investigations.

scholarly journals Risk of Systemic Lupus Erythematosus in Patients With Anti-phospholipid Syndrome: A Population-Based Study

2021 ◽  
Vol 8 ◽  
Author(s):  
Hsin-Hua Chen ◽  
Ching-Heng Lin ◽  
Wen-Cheng Chao
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Population Based ◽  
Sensitivity Analyses ◽  
Research Database ◽  
Newly Diagnosed ◽  
Systemic Lupus ◽  
Population Based Study ◽  
Increased Risk ◽  
Anti Phospholipid Syndrome

Objective: To investigate the association between anti-phospholipid syndrome (APS) and the risk of newly diagnosed systemic lupus erythematosus (SLE).Methods: We used 2003–2013 data derived from Taiwan's National Health Insurance Research Database to conduct this nationwide, population-based. We identified AS patients newly diagnosed between 2005 to 2013 as the study group and applied age-sex matched (1:20) and propensity score-matched (PSM) (1:2) non-SLE individuals as controls. The association between APS and risk of incident SLE was determined by calculating hazard ratios (HRs) with 95% confidence intervals (CIs) using Cox proportional hazard regression analysis.Results: We identified 1,245 patients with APS as well as 24,900 age- and sex-matched non-APS controls and 727 APS patients as well as 1,454 PSM non-APS controls. We found that the risk for incident SLE in the APS group was 80.70 times higher than the non-APS group, and the association remained robust after PSM (HR, 28.55; 95% CI, 11.49–70.91). The increased risk for SLE in patients with APS mainly existed within 5 years after the diagnosis of APS. The sensitivity analyses found that the risk for SLE in patients with APS was consistent excluding patients with ITP/AIHA and using distinct definitions of SLE.Conclusion: The present population-based study revealed a robust association between SLE risk and recent APS and highlights the need for vigilance of SLE-associated symptoms in patients who had been diagnosed with APS.

Systemic lupus erythematosus during pregnancy is not associated with school performance in offspring – A Danish population-based study

Lupus ◽  
2020 ◽  
pp. 096120332097307
Author(s):  
Signe S Knudsen ◽  
Julia F Simard ◽  
Jakob S Knudsen ◽  
Jakob Christensen ◽  
Thomas M Laursen ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
School Performance ◽  
Lupus Erythematosus ◽  
Test Scores ◽  
Harmful Effect ◽  
Autism Spectrum ◽  
Systemic Lupus ◽  
National School ◽  
Increased Risk ◽  
In Pregnancy

Introduction Systemic lupus erythematosus (SLE) in pregnancy is considered a risk factor for a range of adverse outcomes in the offspring. Studies have indicated increased risk of neurodevelopmental disorders such as autism spectrum disorders, dyslexia and ADHD. However, the overall long-term cognitive development of children born to women with SLE has scarcely been examined. In this study, we compare test scores from the Danish National School Tests of children born to women SLE with children of the background population. Methods We included all singleton children born in Denmark between 1995 and 2008, who were listed in the Danish National School Test Register (n=738,862). Children born to women with SLE were identified through linkage of national healthcare registers. We assessed the children’s performance in the national school tests between 2nd and 8th grade, in reading and mathematics. Information on the mothers’ redeemed prescriptions in pregnancy was included in stratified analyses. Differences of mean test scores were derived from linear regressions and compared according to maternal SLE status, and predefined categories of medication exposures. Results In total, 312 (0.04%) children were born to mothers with SLE. There were no differences in performance in neither reading nor mathematics tests between those born to mothers with SLE and children born to mothers without SLE. When stratifying on medication exposures among children whose mothers had SLE, there was a non-significant tendency towards poorer results among those exposed to hydroxychloroquine and/or immunosuppressants (n=31), compared to those not exposed to these medications. A similar tendency was not observed among children whose mothers received hydroxychloroquine for non-SLE reasons (n=1,235) Conclusion This study indicates no major harmful effect on the child’s neurocognitive development from exposure in utero to SLE, hydroxychloroquine and/or immunosuppressants, as measured by school performance.

Sign in / Sign up

Export Citation Format

Share Document