Microwave-Assisted Hydrothermal Rapid Synthesis of Amorphous Calcium Phosphate Mesoporous Microspheres Using Adenosine 5′-Diphosphate and Application in pH-Responsive Drug Delivery

2015 ◽  
Vol 10 (11) ◽  
pp. 2503-2511 ◽  
Author(s):  
Chao Qi ◽  
Ying-Jie Zhu ◽  
Tuan-Wei Sun ◽  
Jin Wu ◽  
Feng Chen
Keyword(s):  
Drug Delivery ◽  
Calcium Phosphate ◽  
Amorphous Calcium Phosphate ◽  
Ph Responsive ◽  
Rapid Synthesis ◽  
Microwave Assisted ◽  
Mesoporous Microspheres

Multifunctional biodegradable mesoporous microspheres of Eu3+-doped amorphous calcium phosphate: microwave-assisted preparation, pH-sensitive drug release, and bioimaging application

2014 ◽  
Vol 2 (41) ◽  
pp. 7132-7140 ◽  
Author(s):  
Feng Chen ◽  
Peng Huang ◽  
Chao Qi ◽  
Bing-Qiang Lu ◽  
Xin-Yu Zhao ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Drug Release ◽  
Adenosine Triphosphate ◽  
Amorphous Calcium Phosphate ◽  
Solvothermal Method ◽  
Ph Sensitive ◽  
Microwave Assisted ◽  
Mesoporous Microspheres

Mesoporous microspheres of Eu3+-doped amorphous calcium phosphate are prepared using adenosine triphosphate by the microwave solvothermal method.

Porous hollow microspheres of amorphous calcium phosphate: soybean lecithin templated microwave-assisted hydrothermal synthesis and application in drug delivery

2015 ◽  
Vol 3 (9) ◽  
pp. 1823-1830 ◽  
Author(s):  
Guan-Jun Ding ◽  
Ying-Jie Zhu ◽  
Chao Qi ◽  
Bing-Qiang Lu ◽  
Feng Chen ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Hydrothermal Synthesis ◽  
Calcium Phosphate ◽  
Adenosine Triphosphate ◽  
Amorphous Calcium Phosphate ◽  
Soybean Lecithin ◽  
Hollow Microspheres ◽  
Microwave Assisted

Microwave-assisted hydrothermal synthesis of porous hollow microspheres of amorphous calcium phosphate using adenosine triphosphate, CaCl2 and soybean lecithin is reported.

Precise morphology control of phosphate-based nanospheres via magnesium and application in drug delivery

2021 ◽  
Keyword(s):  
Drug Delivery ◽  
Cell Proliferation ◽  
Calcium Phosphate ◽  
Cell Growth ◽  
Ph Responsive ◽  
Cancer Cell Growth ◽  
Rapid Synthesis ◽  
Template Free ◽  
Porous Magnesium ◽  
Strontium Phosphate

The present work investigates a template-free and rapid synthesis of phosphate-based porous nanospheres via magnesium. The study reveals the magnesium plays a guide role in the formation of amorphous porous magnesium substituted nanospheres, including calcium phosphate (CaP), strontium phosphate (SrP) and barium phosphate (BaP). Cell viabilities of three kinds of particles were evaluated and CaP nanospheres indicated best biocompatibility. Thus, amorphous magnesium substituted CaP nanospheres were chosen as doxorubicin (DOX) carrier for drug delivery in cancer treatment and pH-responsive magnesium substitution can switch on under tumour acidic microenvironment and facilitate controlled sustained DOX release. The CaP nanospheres gave a sustainable release within 150 minutes. The results showed free DOX has better efficiency at killing cancer cells than CaP/DOX at 4 h. However, CaP/DOX systems effectively suppressed the cell proliferation comparing with free DOX at 36 h. Collectively, this simple and templet-free method for synthesis of amorphous porous nanospheres could serve as a promising chemo-therapeutics delivery system and effectively inhibition of cancer cell growth.

Vesicle-like nanospheres of amorphous calcium phosphate: sonochemical synthesis using the adenosine 5′-triphosphate disodium salt and their application in pH-responsive drug delivery

2015 ◽  
Vol 3 (37) ◽  
pp. 7347-7354 ◽  
Author(s):  
Chao Qi ◽  
Ying-Jie Zhu ◽  
Yong-Gang Zhang ◽  
Ying-Ying Jiang ◽  
Jin Wu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Calcium Phosphate ◽  
Amorphous Calcium Phosphate ◽  
Disodium Salt ◽  
Ph Responsive ◽  
Sonochemical Synthesis ◽  
Drug Nanocarriers

Amorphous calcium phosphate vesicle-like nanospheres synthesized sonochemically using ATP can be used as pH-responsive drug nanocarriers.

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