Vesicle-like nanospheres of amorphous calcium phosphate: sonochemical synthesis using the adenosine 5′-triphosphate disodium salt and their application in pH-responsive drug delivery

2015 ◽  
Vol 3 (37) ◽  
pp. 7347-7354 ◽  
Author(s):  
Chao Qi ◽  
Ying-Jie Zhu ◽  
Yong-Gang Zhang ◽  
Ying-Ying Jiang ◽  
Jin Wu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Calcium Phosphate ◽  
Amorphous Calcium Phosphate ◽  
Disodium Salt ◽  
Ph Responsive ◽  
Sonochemical Synthesis ◽  
Drug Nanocarriers

Amorphous calcium phosphate vesicle-like nanospheres synthesized sonochemically using ATP can be used as pH-responsive drug nanocarriers.

In Situ Precipitation of Amorphous Calcium Phosphate and Ciprofloxacin Crystals during the Formation of Chitosan Hydrogels and Its Application for Drug Delivery Purposes

Langmuir ◽  
2012 ◽  
Vol 28 (45) ◽  
pp. 15937-15946 ◽  
Author(s):  
Stefania Nardecchia ◽  
María C. Gutiérrez ◽  
M. Concepción Serrano ◽  
Mariella Dentini ◽  
Andrea Barbetta ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Calcium Phosphate ◽  
Amorphous Calcium Phosphate ◽  
Chitosan Hydrogels

Amorphous calcium phosphate nanowires prepared using beta-glycerophosphate disodium salt as an organic phosphate source by a microwave-assisted hydrothermal method and adsorption of heavy metals in water treatment

RSC Advances ◽  
2015 ◽  
Vol 5 (50) ◽  
pp. 40154-40162 ◽  
Author(s):  
Guan-Jun Ding ◽  
Ying-Jie Zhu ◽  
Chao Qi ◽  
Tuan-Wei Sun ◽  
Jin Wu ◽  
...  
Keyword(s):  
Heavy Metals ◽  
Water Treatment ◽  
Calcium Phosphate ◽  
Hydrothermal Method ◽  
Amorphous Calcium Phosphate ◽  
Disodium Salt ◽  
Organic Phosphate ◽  
Microwave Assisted ◽  
Phosphate Source

Amorphous calcium phosphate nanowires were prepared using β-glycerophosphate disodium salt as the phosphate source by a microwave-assisted hydrothermal method.

Preparation of PEG Functionalized Nanoparticles for Drug Delivery to Cancer Cells

2014 ◽  
Vol 893 ◽  
pp. 194-197
Author(s):  
Yan Liu ◽  
Jie Ren ◽  
Jun Zhao Leng ◽  
Jian Bo Li ◽  
Li Deng
Keyword(s):  
Drug Delivery ◽  
Polyethylene Glycol ◽  
Calcium Phosphate ◽  
Zeta Potential ◽  
Cellular Uptake ◽  
Physiological Solution ◽  
Ph Responsive ◽  
Functionalized Nanoparticles ◽  
Calcium Phosphate Nanoparticles ◽  
Reverse Microemulsion Method

Nanosized calcium phosphate was prepared by a reverse microemulsion method, with a 20~40 nm diameter, which is pH-responsive, nontoxic and colloidally stable in physiological solution. Polyethylene glycol modified calcium phosphate nanoparticles shifted the zeta potential to a neutral charge, which prolonged the nanoparticle circulation time and increased cellular uptake efficacy to targeted cells. The PEG-functionalized nanoparticles exhibit a great potential for efficaciously delivering hydrophobic anticancer drug, such as paclitaxel, to cells and tumors.

scholarly journals Highly Porous Amorphous Calcium Phosphate for Drug Delivery and Bio-Medical Applications

Nanomaterials ◽  
2019 ◽  
Vol 10 (1) ◽  
pp. 20 ◽  
Author(s):  
Rui Sun ◽  
Michelle Åhlén ◽  
Cheuk-Wai Tai ◽  
Éva G. Bajnóczi ◽  
Fenne de Kleijne ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Calcium Phosphate ◽  
Amorphous Calcium Phosphate ◽  
Large Angle ◽  
Drug Carriers ◽  
Amorphous Calcium Carbonate ◽  
Practical Applications ◽  
The Stability ◽  
Highly Porous

Amorphous calcium phosphate (ACP) has shown significant effects on the biomineralization and promising applications in bio-medicine. However, the limited stability and porosity of ACP material restrict its practical applications. A storage stable highly porous ACP with Brunauer–Emmett–Teller surface area of over 400 m2/g was synthesized by introducing phosphoric acid to a methanol suspension containing amorphous calcium carbonate nanoparticles. Electron microscopy revealed that the porous ACP was constructed with aggregated ACP nanoparticles with dimensions of several nanometers. Large angle X-ray scattering revealed a short-range atomic order of <20 Å in the ACP nanoparticles. The synthesized ACP demonstrated long-term stability and did not crystallize even after storage for over 14 months in air. The stability of the ACP in water and an α-MEM cell culture medium were also examined. The stability of ACP could be tuned by adjusting its chemical composition. The ACP synthesized in this work was cytocompatible and acted as drug carriers for the bisphosphonate drug alendronate (AL) in vitro. AL-loaded ACP released ~25% of the loaded AL in the first 22 days. These properties make ACP a promising candidate material for potential application in biomedical fields such as drug delivery and bone healing.

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