Apoptosis initiated by dependence receptors: a new paradigm for cell death?

BioEssays ◽  
2004 ◽  
Vol 26 (6) ◽  
pp. 656-664 ◽  
Author(s):  
Alan G. Porter ◽  
Saravanakumar Dhakshinamoorthy
Keyword(s):  
Cell Death ◽  
New Paradigm ◽  
Dependence Receptors

scholarly journals Correction to: Pyroptosis: a new paradigm of cell death for fighting against cancer

2021 ◽  
Vol 40 (1) ◽  
Author(s):  
Yixin Tan ◽  
Quanzhu Chen ◽  
Xiaoling Li ◽  
Zhaoyang Zeng ◽  
Wei Xiong ◽  
...  
Keyword(s):  
Cell Death ◽  
New Paradigm

scholarly journals Super-human cell death detection with biomarker-optimized neural networks

2020 ◽  
Author(s):  
Jeremy W. Linsley ◽  
Drew A. Linsley ◽  
Josh Lamstein ◽  
Gennadi Ryan ◽  
Kevan Shah ◽  
...  
Keyword(s):  
Neural Networks ◽  
Cell Death ◽  
High Throughput ◽  
High Throughput Screening ◽  
Morphological Characteristics ◽  
Ground Truth ◽  
Cell Types ◽  
Live Cells ◽  
New Paradigm ◽  
Cell Vitality

AbstractCell death is an essential process in biology that must be accounted for in live microscopy experiments. Nevertheless, cell death is difficult to detect without perturbing experiments with stains, dyes or biosensors that can bias experimental outcomes, lead to inconsistent results, and reduce the number of processes that can be simultaneously labelled. These additional steps also make live microscopy difficult to scale for high-throughput screening because of the cost, labor, and analysis they entail. We address this fundamental limitation of live microscopy with biomarker-optimized convolutional neural networks (BO-CNN): computer vision models trained with a ground truth biosensor that detect live cells with superhuman, 96% accuracy more than 100 times faster than previous methods. Our models learn to identify important morphological characteristics associated with cell vitality without human input or additional perturbations, and to generalize to other imaging modalities and cell types for which they have no specialized training. We demonstrate that we can interpret decisions from BO-CNN models to gain biological insight into the patterns they use to achieve superhuman accuracy. The BO-CNN approach is broadly useful for live microscopy, and affords a powerful new paradigm for advancing the state of high-throughput imaging in a variety of contexts.

scholarly journals EphB3 receptors function as dependence receptors to mediate oligodendrocyte cell death following contusive spinal cord injury

2015 ◽  
Vol 6 (10) ◽  
pp. e1922-e1922 ◽  
Author(s):  
Y Tsenkina ◽  
J Ricard ◽  
E Runko ◽  
M M Quiala- Acosta ◽  
J Mier ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Cell Death ◽  
Cord Injury ◽  
Contusive Spinal Cord Injury ◽  
Dependence Receptors

The role of necroptosis and apoptosis through the oxidative stress pathway in the liver of selenium-deficient swine

Metallomics ◽  
2020 ◽  
Vol 12 (4) ◽  
pp. 607-616 ◽  
Author(s):  
Yuan Zhang ◽  
Dahai Yu ◽  
Jiuli Zhang ◽  
Jun Bao ◽  
Chaohua Tang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cell Death ◽  
Liver Damage ◽  
New Paradigm ◽  
Oxidative Stress Pathway ◽  
Se Deficiency ◽  
Stress Pathway

Necroptosis is regarded as a new paradigm of cell death that plays a key role in the liver damage observed with selenium (Se) deficiency.

scholarly journals Dependence receptors: a new paradigm in cell signaling and cancer therapy

Oncogene ◽  
2010 ◽  
Vol 29 (13) ◽  
pp. 1865-1882 ◽  
Author(s):  
D Goldschneider ◽  
P Mehlen
Keyword(s):  
Cancer Therapy ◽  
Cell Signaling ◽  
New Paradigm ◽  
Dependence Receptors

scholarly journals Electrochemical Response of Cells Using Bioactive Plant Isolates

2021 ◽  
Author(s):  
Elvis K. Tiburu ◽  
Richard Asiamah ◽  
Bernard O. Asimeng ◽  
Samuel Kojo Kwofie ◽  
Emmanuel Nyankson ◽  
...  
Keyword(s):  
Cell Death ◽  
Bioactive Compounds ◽  
Model Systems ◽  
New Paradigm ◽  
Plant Metabolites ◽  
Tropical Regions ◽  
Biological Interface ◽  
Healthcare Needs ◽  
Electrochemical Response ◽  
Sensing Material

Traditional herbal medical practices continue to be part of the healthcare needs of the world especially residents of sub-Sahara Africa (sSA). However, the mechanism of action of the plant metabolites to elicit their potency continue to be a mystery due to the lack of standardized methods. The mechanism of plant bioactive compounds to cause cell death is gradually being linked to membrane polarization and depolarization behaviour. The current work seeks to probe the electrochemical response of model cells using bioactive compounds captured in bio-zeolites or membrane mimetics. The voltage and current fluctuations emanating from such studies will establish a correlation between cell death and membrane depolarization. It will be a useful biological interface sensing material with the potential to identify plant metabolites that can selectively detect and destroy diseased cells. Several model membranes have already been developed for biomedical applications and this new paradigm will elevate the usefulness of these model systems. The concept was investigated using extracts from Dioclea reflexa (DR) hook which belongs to the leguminous family. There are certain class of compounds in Dioclea reflexa (DR) that have clinical usefulness in both temperate and tropical regions, however the identity of the bioactive compounds responsible for inducing cell death continue to be a major challenge.

scholarly journals Control of cell death/survival balance by the MET dependence receptor

eLife ◽  
2020 ◽  
Vol 9 ◽  
Author(s):  
Leslie Duplaquet ◽  
Catherine Leroy ◽  
Audrey Vinchent ◽  
Sonia Paget ◽  
Jonathan Lefebvre ◽  
...  
Keyword(s):  
Cell Death ◽  
Caspase Cleavage ◽  
Physiological Importance ◽  
Signaling Mechanisms ◽  
Caspase Cleavage Site ◽  
Dependence Receptors ◽  
Dependence Receptor ◽  
Shed Light ◽  
Membrane Region

Control of cell death/survival balance is an important feature to maintain tissue homeostasis. Dependence receptors are able to induce either survival or cell death in presence or absence of their ligand, respectively. However, their precise mechanism of action and their physiological importance are still elusive for most of them including the MET receptor. We evidence that pro-apoptotic fragment generated by caspase cleavage of MET localizes to the mitochondria-associated membrane region. This fragment triggers a calcium transfer from endoplasmic reticulum to mitochondria, which is instrumental for the apoptotic action of the receptor. Knock-in mice bearing a mutation of MET caspase cleavage site highlighted that p40MET production is important for FAS-driven hepatocyte apoptosis, and demonstrate that MET acts as a dependence receptor in vivo. Our data shed light on new signaling mechanisms for dependence receptors’ control of cell survival/death balance, which may offer new clues for the pathophysiology of epithelial structures.

scholarly journals Pyroptosis: a new paradigm of cell death for fighting against cancer

2021 ◽  
Vol 40 (1) ◽  
Author(s):  
Yixin Tan ◽  
Quanzhu Chen ◽  
Xiaoling Li ◽  
Zhaoyang Zeng ◽  
Wei Xiong ◽  
...  
Keyword(s):  
Cell Death ◽  
Tumor Immunity ◽  
Immune Therapy ◽  
Main Body ◽  
Cancer Therapies ◽  
Microbial Infection ◽  
New Paradigm ◽  
Tumor Microenvironments ◽  
Regulated Cell Death ◽  
Tumor Suppressive Function

Abstract Background Unraveling the mystery of cell death is one of the most fundamental progresses of life sciences during the past decades. Regulated cell death (RCD) or programmed cell death (PCD) is not only essential in embryonic development, but also plays an important role in the occurrence and progression of diseases, especially cancers. Escaping of cell death is one of hallmarks of cancer. Main body Pyroptosis is an inflammatory cell death usually caused by microbial infection, accompanied by activation of inflammasomes and maturation of pro-inflammatory cytokines interleukin-1β (IL-1β) and interleukin-18 (IL-18). Gasdermin family proteins are the executors of pyroptosis. Cytotoxic N-terminal of gasdermins generated from caspases or granzymes proteases mediated cleavage of gasdermin proteins oligomerizes and forms pore across cell membrane, leading to release of IL-1β, IL-18. Pyroptosis exerts tumor suppression function and evokes anti-tumor immune responses. Therapeutic regimens, including chemotherapy, radiotherapy, targeted therapy and immune therapy, induce pyroptosis in cancer, which potentiate local and systemic anti-tumor immunity. On the other hand, pyroptosis of normal cells attributes to side effects of anti-cancer therapies. Conclusion In this review, we focus on the regulatory mechanisms of pyroptosis and the tumor suppressive function of pyroptosis. We discuss the attribution of pyroptosis in reprogramming tumor microenvironments and restoration of anti-tumor immunity and its potential application in cancer immune therapy.

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