scholarly journals Analytic power and sample size calculation for the genotypic transmission/disequilibrium test in case-parent trio studies

2014 ◽  
Vol 56 (6) ◽  
pp. 1076-1092 ◽  
Author(s):  
Christoph Neumann ◽  
Margaret A. Taub ◽  
Samuel G. Younkin ◽  
Terri H. Beaty ◽  
Ingo Ruczinski ◽  
...  
2012 ◽  
Vol 53 ◽  
Author(s):  
Šarūnas Germanas ◽  
Audronė Jakaitienė

In this paper we apply Poisson distribution in order to approximate the power of the Transmission Disequilibrium Test (TDT). In this research we calculated the power of the TDT for different values of sample size n and different values of allele transmission frequencies p. The research showed that Poisson approximation have smaller errors than Normal approximation when the power is between 0.8 and 0.95 and sample size m is equal or bigger than 50.


2009 ◽  
Vol 8 (1) ◽  
pp. 1-16 ◽  
Author(s):  
Chuanwen Chen ◽  
Guang Yang ◽  
Steven Buyske ◽  
Tara Matise ◽  
Stephen J Finch ◽  
...  

2017 ◽  
Vol 23 (5) ◽  
pp. 644-646 ◽  
Author(s):  
Maria Pia Sormani

The calculation of the sample size needed for a clinical study is the challenge most frequently put to statisticians, and it is one of the most relevant issues in the study design. The correct size of the study sample optimizes the number of patients needed to get the result, that is, to detect the minimum treatment effect that is clinically relevant. Minimizing the sample size of a study has the advantage of reducing costs, enhancing feasibility, and also has ethical implications. In this brief report, I will explore the main concepts on which the sample size calculation is based.


1994 ◽  
Vol 13 (8) ◽  
pp. 859-870 ◽  
Author(s):  
Robert P. McMahon ◽  
Michael Proschan ◽  
Nancy L. Geller ◽  
Peter H. Stone ◽  
George Sopko

2007 ◽  
Vol 77 (5) ◽  
pp. 773-778 ◽  
Author(s):  
Lars Bondemark ◽  
Jola Tsiopa

Abstract Objective: To elucidate the prevalence of ectopic eruption, impaction, and primary and secondary retention as well as agenesis of the permanent second molar (M2) among adolescents. Materials and Methods: After a sample size calculation, dental records, including radiographs, of 1543 patients (722 girls and 821 boys), from three clinics in the city of Malmoe, Sweden, were retrospectively analyzed. Series of annual records and radiographs were examined for all patients from 10 to 16 years of age and were carried out during 2004–2006. The prevalence of ectopic eruption, impaction, and primary and secondary retention as well as agenesis of M2s was registered in a standardized manner and according to preset definitions. In addition, the times of emergence of the M2s were recorded. Results: The prevalence of ectopic eruption of M2 was 1.5%, the prevalence of primary retention was 0.6%, and the prevalence of impaction was 0.2%. This means that the overall prevalence of eruption disturbances was 2.3%. In addition, the prevalence of agenesis was 0.8%. The prevalence of ectopic eruption was significantly higher in the mandible. Those patients with eruption disturbances and agenesis of M2 showed significantly delayed eruption of their other M2s compared to the individuals without any eruption disturbances. Conclusions: The prevalence of eruption disturbances was higher than reported earlier, and, even if the disturbances do not occur frequently, it is important to develop an early diagnosis in order to start the treatment at the optimal time.


2015 ◽  
Vol 82 (3) ◽  
pp. 172-176 ◽  
Author(s):  
Paul Ornetti ◽  
Laure Gossec ◽  
Davy Laroche ◽  
Christophe Combescure ◽  
Maxime Dougados ◽  
...  

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