Classification of early-stage non-small cell lung cancer by weighing gene expression profiles with connectivity information

2017 ◽  
Vol 60 (3) ◽  
pp. 537-546 ◽  
Author(s):  
Ao Zhang ◽  
Suyan Tian
Keyword(s):  
Gene Expression ◽  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Early Stage ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Small Cell ◽  
Small Cell Lung ◽  
Connectivity Information

scholarly journals Changes in GPX1, RHOA and NKIRAS1 gene expression profiles as potential diagnostic markers for non-small cell lung cancer

2018 ◽  
pp. 116-120
Author(s):  
И.В. Пронина ◽  
В.И. Логинов ◽  
Д.С. Ходырев ◽  
Т.П. Казубская ◽  
Э.А. Брага
Keyword(s):  
Gene Expression ◽  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Early Stage ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Small Cell ◽  
Small Cell Lung ◽  
High Prevalence

Рак лёгкого отличает высокая распространенность и смертность, связанные в значительной степени с отсутствием доступных методов ранней диагностики. Методом количественной ОТ-ПЦР показано повышение в 5 и более раз экспрессии 3 генов хромосомы 3 в большинстве образцов немелкоклеточного рака лёгкого (НМРЛ) и его гистологических подвидов: аденокарциномы легкого (АК) и плоскоклеточного рака легкого (ПРЛ). При использовании комбинации из трех генов RHOA, GPX1 и NKIRAS1 повышение экспрессии детектируется в 85% (33/39) НМРЛ, в том числе в 78% (18/23) ПРЛ и 94% АК (15/16). Интересно, что при анализе пациентов только ранних стадий (I/II) чувствительность предложенного набора генов сохраняется и даже несколько повышается. Lung cancer is distinguished by an extremely high prevalence and a high mortality rate due to its late detection and unavailability of methods for early diagnosis. Changes in gene expression were evaluated using quantitative RT-PCR. Expression of several chromosome 3 genes (specifically, RHOA, GPX1, and NKIRAS1) was shown to be increased 5 or more times in most samples of non-small cell lung cancer (NSCLC) and its histological subtypes, lung adenocarcinoma (AC) and squamous cell lung cancer (SLC). When a combination of three genes, RHOA, GPX1 and NKIRAS1, was used increased expression was detected in 85% (33/39) of NSCLC samples, including 78% (18/23) of SLC samples and 94% of AC (15/16) samples. Interestingly, when only samples from early-stage cancer (I/II) patients were analyzed, the sensitivity of the proposed set of genes was preserved and even somewhat increased.

29P RNA SEQ REVEALS GENE EXPRESSION PROFILES OF NON-SMALL CELL LUNG CANCER

Lung Cancer ◽  
2013 ◽  
Vol 80 ◽  
pp. S12-S13
Author(s):  
S. Han ◽  
H. Lee ◽  
S. Lee ◽  
W.J. Kim ◽  
Y. Oh ◽  
...  
Keyword(s):  
Gene Expression ◽  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Small Cell ◽  
Rna Seq ◽  
Small Cell Lung

Chromosomal aberrations and gene expression profiles in non-small cell lung cancer

Lung Cancer ◽  
2007 ◽  
Vol 56 (2) ◽  
pp. 175-184 ◽  
Author(s):  
E. Dehan ◽  
A. Ben-Dor ◽  
W. Liao ◽  
D. Lipson ◽  
H. Frimer ◽  
...  
Keyword(s):  
Gene Expression ◽  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Chromosomal Aberrations ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Small Cell ◽  
Small Cell Lung
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