Growth factor sustained delivery from poly‐lactic‐co‐glycolic acid microcarriers and its mass transfer modeling by finite element in a dynamic and static three‐dimensional environment bioengineered with stem cells

2019 ◽  
Vol 116 (7) ◽  
pp. 1777-1794 ◽  
Author(s):  
Emanuele Trucillo ◽  
Bruno Bisceglia ◽  
Giovanni Valdrè ◽  
Emanuele Giordano ◽  
Ernesto Reverchon ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mass Transfer ◽  
Finite Element ◽  
Growth Factor ◽  
Glycolic Acid ◽  
Three Dimensional ◽  
Sustained Delivery ◽  
Mass Transfer Modeling

scholarly journals Synthesis of embryonic tendon-like tissue by human marrow stromal/mesenchymal stem cells requires a three-dimensional environment and transforming growth factor β3

2010 ◽  
Vol 29 (8) ◽  
pp. 668-677 ◽  
Author(s):  
Zoher Kapacee ◽  
Ching-Yan Chloé Yeung ◽  
Yinhui Lu ◽  
David Crabtree ◽  
David F. Holmes ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Growth Factor ◽  
Transforming Growth Factor ◽  
Three Dimensional ◽  
Embryonic Tendon

Epidermal growth factor and three‐dimensional scaffolds provide conducive environment for differentiation of mouse embryonic stem cells into oocyte‐like cells

2020 ◽  
Vol 44 (9) ◽  
pp. 1850-1859
Author(s):  
Azam Soleimani ◽  
Nehleh Zarei Fard ◽  
Tahereh Talaei‐Khozani ◽  
Soghra Bahmanpour
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Three Dimensional ◽  
Embryonic Stem ◽  
Mouse Embryonic Stem Cells ◽  
Epidermal Growth ◽  
Conducive Environment

EVALUATION OF THREE DIMENSIONAL CONSTRUCT ENGINEERED FROM POLY(LACTIC-CO-GLYCOLIC ACID)/FIBRIN HYBRID SCAFFOLD USING RABBIT BONE MARROW MESENCHYMAL STEM CELLS FOR OSTEOCHONDRAL DEFECT REPAIR

2015 ◽  
Vol 77 (25) ◽  
Author(s):  
Rozlin Abdul Rahman ◽  
Norhamiza Mohamad Sukri ◽  
Noorhidayah Md Nazir ◽  
Muhammad Aa’zamuddin Ahmad Radzi ◽  
Ahmad Hafiz Zulkifly ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Glycolic Acid ◽  
Osteochondral Defect ◽  
Rabbit Model ◽  
Three Dimensional ◽  
Marker Genes ◽  
Repair Capacity ◽  
Marrow Mesenchymal Stem Cells

Articular cartilage has poor repair capacity due to its avascular and aneural properties and has relatively few cells. This study investigated the ability of autologous implantation approach using three dimensional (3D) constructs engineered from bone marrow mesenchymal stem cells (BMSCs) seeded on poly(lactic-co-glycolic acid) (PLGA) with or without fibrin as cells carrier for the repair of osteochondral defect in rabbit model. The engineered 3D constructs – PLGA/Fibrin/BMSCs and PLGA/BMSCs – were cultured for 3 weeks in vitro and implanted autologously to the osteochondral defect created in the rabbit knee. The in vivo constructs were harvested and evaluated by means of gross observation, histology assessment, gene expression study, sulphated glycosaminoglycan (sGAG) production assay and biomechanical evaluation at 6 and 12 weeks post implantation. The results showed that the osteochondral defects treated with the PLGA/Fibrin/BMSCs constructs exhibited better repairment, more cartilaginous extracellular matrix, higher sGAG production, superior compressive strength and more intense expression of chondrogenic marker genes than the PLGA/BMSCs group. This study suggested that the PLGA/Fibrin/BMSCs has the potential to treat osteochondral defect and may be presented as a viable therapeutic option for those who would be in need from the life-extending benefits of tissue replacement or repair.

scholarly journals Measuring Three-Dimensional Traction Force of Mesenchymal Stem Cells on a Two-Dimensional Compliant Substrate by the Finite Element Method

2015 ◽  
Vol 108 (2) ◽  
pp. 306a
Author(s):  
Hung-huei Lee ◽  
Hsuan Yang ◽  
Yu-chi Ai ◽  
Keng-hui Lin ◽  
Jia-yang Juang
Keyword(s):  
Finite Element Method ◽  
Stem Cells ◽  
Finite Element ◽  
Mesenchymal Stem Cells ◽  
Three Dimensional ◽  
Traction Force ◽  
Two Dimensional ◽  
The Finite Element Method ◽  
Compliant Substrate ◽  
Element Method

Sustained delivery of vascular endothelial growth factor using a dextran/poly(lactic-co-glycolic acid)-combined microsphere system for therapeutic neovascularization

2018 ◽  
Vol 34 (1) ◽  
pp. 167-176 ◽  
Author(s):  
Zhen Dong Zhang ◽  
Ying Qi Xu ◽  
Feng Chen ◽  
Jun Fu Luo ◽  
Chong Dong Liu
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Glycolic Acid ◽  
Vascular Endothelial ◽  
Sustained Delivery ◽  
Endothelial Growth Factor

Three-dimensional mass transfer modeling of ibuprofen adsorption on activated carbon prepared by sonication

2018 ◽  
Vol 341 ◽  
pp. 65-74 ◽  
Author(s):  
A.C. Fröhlich ◽  
R. Ocampo-Pérez ◽  
V. Diaz-Blancas ◽  
N.P.G. Salau ◽  
G.L. Dotto
Keyword(s):  
Mass Transfer ◽  
Activated Carbon ◽  
Three Dimensional ◽  
Mass Transfer Modeling
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