A new generation of predictive models: The added value of hybrid models for manufacturing processes of therapeutic proteins

Family businesses are considered as an important source of economic development and growth in that they create added value by providing new products, processes and technologies. Family businesses, where family values and perspectives dominate, have begun to experience problems in adapting to such a structure in the global economy, where the rate of change has increased, and the competition is intense. In the process of restructuring, entrepreneurial orientation is vital for these businesses. From this point of view, the aim of this chapter is to define family business, to explain their characteristics and to show the two perspectives on the entrepreneurial orientation of family businesses. The concept of “family entrepreneurship” and “transgenerational entrepreneurship” is also mentioned in the chapter. In relation to what is told in the chapter, how a conservative structure has been opened to the market by its third generation, a family business in Turkey that is going through its third generation and the innovations brought about by the new generation compose the case study.

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Multivariate SPC methods for controlling manufacturing processes using predictive models – A case study in the automotive sector

Computers in Industry ◽

10.1016/j.compind.2020.103307 ◽

2020 ◽

Vol 123 ◽

pp. 103307

Author(s):

Rafael Sanchez-Marquez ◽

José Manuel Jabaloyes Vivas

Keyword(s):

Predictive Models ◽

Manufacturing Processes ◽

Automotive Sector

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How We Care for an Older Patient With Cancer

Journal of Oncology Practice ◽

10.1200/jop.2016.017608 ◽

2017 ◽

Vol 13 (2) ◽

pp. 95-102 ◽

Cited By ~ 20

Author(s):

Armin Shahrokni ◽

Soo Jung Kim ◽

George J. Bosl ◽

Beatriz Korc-Grodzicki

Keyword(s):

Predictive Models ◽

Older Patients ◽

Process Development ◽

Adverse Outcomes ◽

Added Value ◽

Cancer Center ◽

Multiple Chronic Conditions ◽

Older Patient ◽

Improve Patient Survival ◽

Patients With Cancer

As the number of older patients with cancer is increasing, oncology disciplines are faced with the challenge of managing patients with multiple chronic conditions who have difficulty maintaining independence, who may have cognitive impairment, and who also may be more vulnerable to adverse outcomes. National and international societies have recommended that all older patients with cancer undergo geriatric assessment (GA) to detect unaddressed problems and introduce interventions to augment functional status to possibly improve patient survival. Several predictive models have been developed, and evidence has shown correlation between information obtained through GA and treatment-related complications. Comprehensive geriatric evaluations and effective interventions on the basis of GA may prove to be challenging for the oncologist because of the lack of the necessary skills, time constraints, and/or limited available resources. In this article, we describe how the Geriatrics Service at Memorial Sloan Kettering Cancer Center approaches an older patient with colon cancer from presentation to the end of life, show the importance of GA at the various stages of cancer treatment, and how predictive models are used to tailor the treatment. The patient’s needs and preferences are at the core of the decision-making process. Development of a plan of care should always include the patient’s preferences, but it is particularly important in the older patient with cancer because a disease-centered approach may neglect noncancer considerations. We will elaborate on the added value of co-management between the oncologist and a geriatric nurse practitioner and on the feasibility of adapting elements of this model into busy oncology practices.

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Acceptance and commitment therapy: the new wave of cognitive behavior therapy

SCHOULID Indonesian Journal of School Counseling ◽

10.23916/schoulid.v1i1.28.1-5 ◽

2016 ◽

Vol 1 (1) ◽

pp. 1

Author(s):

Wahyu Nanda Eka Saputra ◽

Santi Widiasari

Keyword(s):

School Counselors ◽

Acceptance And Commitment Therapy ◽

Behavior Therapy ◽

Cognitive Behavior Therapy ◽

Behavioral Interventions ◽

Added Value ◽

Cognitive Behavior ◽

Commitment Therapy ◽

Acceptance And Commitment ◽

New Generation

Cognitive behavior therapy (CBT) is one of the major counseling theories today. However, reliability of this theory has received criticism from other theories, which claim to cognitive interventions do not provide added value on behavioral interventions. The theory criticized and showed dissatisfaction with the practice of CBT is the theory of Acceptance and Commitment Therapy (ACT). Furthermore, ACT is known to a new generation of CBT.ACT is one of the new counseling approach that can be applied to school counselors to deal with the issues of students in the school.

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Costs Analysis of Iron Casts Manufacturing

Archives of Foundry Engineering ◽

10.2478/v10266-012-0034-9 ◽

2012 ◽

Vol 12 (2) ◽

pp. 45-48 ◽

Cited By ~ 1

Author(s):

S. Kukla

Keyword(s):

Added Value ◽

Manufacturing Processes ◽

Production Flow ◽

Pareto Analysis ◽

Costs Analysis ◽

Constant Improvement ◽

Plant Transport

Costs Analysis of Iron Casts Manufacturing The article presents the issues of costs analysis of iron casts manufacturing using automated foundry lines. Particular attention was paid to departmental costs, conversion costs and costs of in-plant transport. After the Pareto analysis had been carried out, it was possible to set the model area of the process and focus on improving activities related to finishing of a chosen group of casts. In order to eliminate losses, the activities realised in this domain were divided into activities with added value, activities with partially added value and activities without added value. To streamline the production flow, it was proposed to change the location of workstations related to grinding, control and machining of casts. Within the process of constant improvement of manufacturing processes, the aspect of work ergonomics at a workstation was taken into account. As a result of the undertaken actions, some activities without added value were eliminated, efficiency was increased and prime costs of manufacturing casts with regard to finishing treatment were lowered.

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Laser Microdrilling of Slate Tiles

Materials ◽

10.3390/ma12030398 ◽

2019 ◽

Vol 12 (3) ◽

pp. 398 ◽

Cited By ~ 1

Author(s):

Joaquín Penide ◽

Antonio Riveiro ◽

Ramón Soto ◽

Mohamed Boutinguiza ◽

Felipe Arias-Gonzalez ◽

...

Keyword(s):

Co2 Laser ◽

Processing Parameters ◽

Added Value ◽

Lead Times ◽

Manufacturing Processes ◽

Hole Quality ◽

Natural Rock ◽

Increase Productivity ◽

New Processing ◽

Conventional Drilling

Slate is a natural rock usually used in roofs, façades, and for tiling. In spite of this broad use, the production process of slate tiles requires substantial improvements. An important quantity of slate from the quarry is wasted during the manufacturing of the final product. Furthermore, processes are not automatized and the production lead times can be considerably shortened. Therefore, new processing methods to increase productivity, reduce costs and to provide added value to the final slate product are required. Drilling is an important part of these manufacturing processes. Conventional drilling processes usually cause the breaking of the slate tiles; then, even a higher quantity of material is wasted. To overcome these problems, lasers emerge as a feasible tool to produce holes in this material, since mechanical stresses are not induced on the workpiece. In this work, we have studied the CO2 laser microdrilling of slate tiles. We used a Design of Experiments (DOE) methodology to determine the influence of the laser processing parameters on the hole quality. This work demonstrates the capability of a CO2 laser to produce holes in slate with less than 100 microns in diameter, avoiding any fracture, and with a processing time of less than 50 ms per hole. Finally, this process demonstrates the viability of the production of high-density micron-sized holes in a slate tile for water draining purposes.

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Mesoporous bioactive glasses: Relevance of their porous structure compared to that of classical bioglasses

Biomedical glasses ◽

10.1515/bglass-2015-0014 ◽

2015 ◽

Vol 1 (1) ◽

Cited By ~ 38

Author(s):

Isabel Izquierdo-Barba ◽

María Vallet-Regí

Keyword(s):

Bone Tissue ◽

Nanostructured Materials ◽

Tissue Regeneration ◽

Sol Gel ◽

Added Value ◽

Bone Tissue Regeneration ◽

Chemical Compositions ◽

Bioactive Glasses ◽

Gel Glasses ◽

New Generation

AbstractIn the last decade, the development of third generation bioceramics for Bone Tissue Regeneration has experienced significant progress with the emergence of a new generation of nanostructured materials named mesoporous bioactive glasses (MBG). This new generation of materials, also known as “templated glasses”, presents chemical compositions similar to those of conventional bioactive sol–gel glasses and the added value of an ordered mesopore arrangement. This article shows an indepth comparative study of the ordered porous structures of MBGs compared to conventional glasses (melt and solgel) andhowthese properties influence the bioactivity process. Moreover, the possibility to tailor the textural and structural properties of these nanostructured materials by an exhaustive control of the different synthesis parameters is also discussed. A brief overview regarding the possibility of using these materials as controlled drug delivery systems and as starting materials for the fabrication of 3D scaffolds for bone tissue regeneration is also given.

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