scholarly journals Impacts on product quality attributes of monoclonal antibodies produced in CHO cell bioreactor cultures during intentional mycoplasma contamination events

2020 ◽  
Vol 117 (9) ◽  
pp. 2802-2815
Author(s):  
Erica J. Fratz‐Berilla ◽  
Phillip Angart ◽  
Ryan J. Graham ◽  
David N. Powers ◽  
Adil Mohammad ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
Product Quality ◽  
Quality Attributes ◽  
Mycoplasma Contamination ◽  
Cho Cell ◽  
Bioreactor Cultures ◽  
Contamination Events

scholarly journals Impacts of intentional mycoplasma contamination on CHO cell bioreactor cultures

2019 ◽  
Vol 116 (12) ◽  
pp. 3242-3252
Author(s):  
Erica J. Fratz‐Berilla ◽  
Talia Faison ◽  
Casey L. Kohnhorst ◽  
Sai Rashmika Velugula‐Yellela ◽  
David N. Powers ◽  
...  
Keyword(s):  
Mycoplasma Contamination ◽  
Cho Cell ◽  
Bioreactor Cultures

scholarly journals Tunable Protein Crystal Size Distribution via Continuous Slug-Flow Crystallization with Spatially Varying Temperature

CrystEngComm ◽  
2021 ◽  
Author(s):  
Nicholas Mozdzierz ◽  
Moo Sun Hong ◽  
Yongkyu Lee ◽  
Moritz Benisch ◽  
Mo Jiang ◽  
...  
Keyword(s):  
Product Quality ◽  
Size Distribution ◽  
Slug Flow ◽  
Crystal Size ◽  
Quality Attributes ◽  
Crystal Size Distribution ◽  
Protein Crystal ◽  
Manufacturing Cost ◽  
Spatially Varying

Accompanied with the growth of the biopharmaceuticals market has been an interest in developing processes with increased control of product quality attributes at low manufacturing cost, with one of the...

Determination of critical quality attributes for monoclonal antibodies using quality by design principles

Biologicals ◽  
2016 ◽  
Vol 44 (5) ◽  
pp. 291-305 ◽  
Author(s):  
Nadja Alt ◽  
Taylor Y. Zhang ◽  
Paul Motchnik ◽  
Ron Taticek ◽  
Valerie Quarmby ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
Quality By Design ◽  
Design Principles ◽  
Quality Attributes ◽  
Critical Quality Attributes

Online/at‐line measurement, analysis and control of product titer and critical product quality attributes (CQAs) during process development

2020 ◽  
Vol 117 (12) ◽  
pp. 3757-3765 ◽  
Author(s):  
Letha Chemmalil ◽  
Tanushree Prabhakar ◽  
June Kuang ◽  
Jay West ◽  
Zhijun Tan ◽  
...  
Keyword(s):  
Product Quality ◽  
Process Development ◽  
Quality Attributes ◽  
Product Titer ◽  
Measurement Analysis ◽  
Line Measurement ◽  
And Control
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