Anorectal physiology validated: A repeatability study of the motor and sensory tests of anorectal function

1989 ◽  
Vol 76 (6) ◽  
pp. 607-609 ◽  
Author(s):  
J. Rogers ◽  
S. Laurberg ◽  
J. J. Misiewicz ◽  
M. M. Henry ◽  
M. Swash
Keyword(s):  
Anorectal Function ◽  
Anorectal Physiology ◽  
Sensory Tests

scholarly journals Recommendations for the Protocol of functional examination of the anorectal zone and disorders classification: the International Anorectal Physiology Working Group consensus and Russian real-world practice

2020 ◽  
Vol 92 (12) ◽  
pp. 105-119
Author(s):  
O. Yu. Fomenko ◽  
S. V. Morozov ◽  
S. Mark Scott ◽  
H. Charles Knowles ◽  
D. A. Morozov ◽  
...  
Keyword(s):  
Real World ◽  
Working Group ◽  
Anorectal Function ◽  
Anorectal Physiology ◽  
Rectal Sensation ◽  
High Resolution Manometry ◽  
Additional Information ◽  
Wide Range ◽  
Balloon Expulsion ◽  
Function Testing

This manuscript summarizes consensus reached by the International Anorectal Physiology Working Group (IAPWG) for the performance, terminology used, and interpretation of anorectal function testing including anorectal manometry (focused on high-resolution manometry), the rectal sensory test, and the balloon expulsion test. Based on these measurements, a classification system for disorders of anorectal function is proposed. Aim to provide information about methods of diagnosis and new classification of functional anorectal disorders to a wide range of specialists general practitioners, therapists, gastroenterologists, coloproctologists all who face the manifestations of these diseases in everyday practice and determine the diagnostic and therapeutic algorithm. Current paper provides agreed statements of IAPWG Consensus and comments (in italics) of Russian experts on real-world practice, mainly on methodology of examination. These comments in no way intended to detract from the provisions agreed by the international group of experts. We hope that these comments will help to improve the quality of examination based on the systematization of local experience with the use of the methods discussed and the results obtained. Key recommendations: the International Anorectal Physiology Working Group protocol for the performance of anorectal function testing recommends a standardized sequence of maneuvers to test rectoanal reflexes, anal tone and contractility, rectoanal coordination, and rectal sensation. Major findings not seen in healthy controls defined by the classification are as follows: rectoanal areflexia, anal hypotension and hypocontractility, rectal hyposensitivity, and hypersensitivity. Minor and inconclusive findings that can be present in health and require additional information prior to diagnosis include anal hypertension and dyssynergia.

Simulated stool for assessment of anorectal physiology

2020 ◽  
Vol 319 (4) ◽  
pp. G462-G468
Author(s):  
Ssu-Chi Chen ◽  
Kaori Futaba ◽  
Wing Wa Leung ◽  
Cherry Wong ◽  
Tony Mak ◽  
...  
Keyword(s):  
Anorectal Function ◽  
Anorectal Physiology ◽  
Motor Disorders ◽  
Dynamic Measurements ◽  
Rectal Compliance ◽  
Defecatory Function ◽  
Novel Technology ◽  
Patient Groups ◽  
Anorectal Diseases ◽  
Advanced Analysis

Fecal continence is maintained by several mechanisms including anatomical factors, anorectal sensation, rectal compliance, stool consistency, anal muscle strength, mobility, and psychological factors. The homeostatic balance is easily disturbed, resulting in symptoms including fecal incontinence and constipation. Current technologies for assessment of anorectal function have limitations. Overlap exist between data obtained in different patient groups, and there is lack of correlation between measurements and symptoms. This review describes a novel technology named Fecobionics for assessment of anorectal physiology. Fecobionics is a simulated stool, capable of dynamic measurements of a variety of variables during defecation in a single examination. The data facilitate novel analysis of defecatory function as well as providing the foundation for modeling studies of anorectal behavior. The advanced analysis can enhance our physiological understanding of defecation and future interdisciplinary research for unraveling defecatory function, anorectal sensory-motor disorders, and symptoms. This is a step in the direction of improved diagnosis of anorectal diseases.

scholarly journals Tu2022 Assessment of Anorectal Function in Asymptomatic Volunteers Using a New High Resolution Manometric Recording System

2012 ◽  
Vol 142 (5) ◽  
pp. S-904 ◽  
Author(s):  
Anne Brokjær ◽  
S. Mark Scott ◽  
Somnath Palit ◽  
Natalia Zarate
Keyword(s):  
High Resolution ◽  
Anorectal Function ◽  
Recording System ◽  
Asymptomatic Volunteers

scholarly journals Prevalence and Clinical Characteristics of Dyssynergic Defecation and Slow Transit Constipation in Patients with Chronic Constipation

2021 ◽  
Vol 10 (9) ◽  
pp. 2027
Author(s):  
Samuel Tanner ◽  
Ahson Chaudhry ◽  
Navneet Goraya ◽  
Rohan Badlani ◽  
Asad Jehangir ◽  
...  
Keyword(s):  
Medical History ◽  
Chronic Constipation ◽  
Clinical Characteristics ◽  
Anorectal Function ◽  
Slow Transit Constipation ◽  
Dyssynergic Defecation ◽  
Patient Demographics ◽  
Balloon Expulsion ◽  
Slow Transit ◽  
Transit Constipation

Patients with chronic constipation who do not respond to initial treatments often need further evaluation for dyssynergic defecation (DD) and slow transit constipation (STC). The aims of this study are to characterize the prevalence of DD and STC in patients referred to a motility center with chronic constipation and correlate diagnoses of DD and STC to patient demographics, medical history, and symptoms. High-resolution ARM (HR-ARM), balloon expulsion testing (BET) and whole gut transit scintigraphy (WGTS) of consecutive patients with chronic constipation were reviewed. Patients completed questionnaires describing their medical history and symptoms at the time of testing. A total of 230 patients completed HR-ARM, BET, and WGTS. Fifty (22%) patients had DD, and 127 (55%) patients had STC. Thirty patients (13%) had both DD and STC. There were no symptoms that were suggestive of STC vs. DD; however, patients with STC and DD reported more severe constipation than patients with normal transit and anorectal function. Patients with chronic constipation often need evaluation for both DD and STC to better understand their pathophysiology of symptoms and help direct treatment.

scholarly journals A Luminescence-Based Human TRPV1 Assay System for Quantifying Pungency in Spicy Foods

Foods ◽  
2021 ◽  
Vol 10 (1) ◽  
pp. 151
Author(s):  
Minami Matsuyama ◽  
Yuko Terada ◽  
Toyomi Yamazaki-Ito ◽  
Keisuke Ito
Keyword(s):  
Fluorescent Probe ◽  
Evaluation System ◽  
Food Samples ◽  
Assay System ◽  
Sensory Test ◽  
Chemosensory Receptor ◽  
Luminescence Assay ◽  
Transient Receptor ◽  
Sensory Tests ◽  
Fluorescence Dyes

The quantitation of pungency is difficult to achieve using sensory tests because of persistence, accumulation, and desensitization to the perception of pungency. Transient receptor vanilloid 1 (TRPV1), which is a chemosensory receptor, plays a pivotal role in the perception of many pungent compounds, suggesting that the activity of this receptor might be useful as an index for pungency evaluation. Although Ca2+-sensitive fluorescence dyes are commonly used for measuring human TRPV1 (hTRPV1) activity, their application is limited, as foods often contain fluorescent substances that interfere with the fluorescent signals. This study aims to design a new pungency evaluation system using hTRPV1. Instead of employing a fluorescent probe as the Ca2+ indicator, this assay system uses the luminescent protein aequorin. The luminescence assay successfully evaluated the hTRPV1 activity in foods without purification, even for those containing fluorescent substances. The hTRPV1 activity in food samples correlated strongly with the pungency intensity obtained by the human sensory test. This luminescence-based hTRPV1 assay system will be a powerful tool for objectively quantifying the pungency of spicy foods in both laboratory and industrial settings.

Sa409 TERMINOLOGY IMPACTS SIMULATED DEFECATION RESPONSES DURING ANORECTAL MANOMETRY: ANALYSIS OF THE LONDON CLASSIFICATION FOR DISORDERS OF ANORECTAL FUNCTION

2021 ◽  
Vol 160 (6) ◽  
pp. S-498
Author(s):  
Jason R. Baker ◽  
Mackenzie Jarvis ◽  
Elyse Thakur ◽  
William D. Chey ◽  
Rafat Risk ◽  
...  
Keyword(s):  
Anorectal Manometry ◽  
Anorectal Function

scholarly journals Measurement Error of a Simplified Protocol for Quantitative Sensory Tests in Chronic Pain Patients

2017 ◽  
Vol 42 (5) ◽  
pp. 660-668 ◽  
Author(s):  
Monika Müller ◽  
José Alberto Biurrun Manresa ◽  
Andreas Limacher ◽  
Konrad Streitberger ◽  
Peter Jüni ◽  
...  
Keyword(s):  
Chronic Pain ◽  
Measurement Error ◽  
Chronic Pain Patients ◽  
Quantitative Sensory Tests ◽  
Pain Patients ◽  
Sensory Tests
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