scholarly journals Pro12Ala polymorphism of peroxisome proliferator activated receptor gamma 2 may be associated with adverse neurodevelopment in European preterm babies

2021 ◽  
Author(s):  
Suresh Victor ◽  
Andrew Chew ◽  
Shona Falconer
Keyword(s):  
Peroxisome Proliferator ◽  
Pro12ala Polymorphism ◽  
Peroxisome Proliferator Activated Receptor ◽  
Preterm Babies

Association of Pro12Ala polymorphism in peroxisome proliferator-activated receptor gamma with polycystic ovary syndrome: a meta-analysis

2012 ◽  
Vol 39 (10) ◽  
pp. 9649-9660 ◽  
Author(s):  
Song-tao Tang ◽  
Chang-jiang Wang ◽  
Hai-qin Tang ◽  
Wen-jia Peng ◽  
You-min Wang ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Meta Analysis ◽  
Peroxisome Proliferator ◽  
Pro12ala Polymorphism ◽  
Ovary Syndrome ◽  
Peroxisome Proliferator Activated Receptor

Association of Peroxisome Proliferator-Activated Receptor-Gamma 2 Pro12Ala Polymorphism with Advanced-Stage Endometriosis

2010 ◽  
pp. no-no
Author(s):  
Kyu Ri Hwang ◽  
Young Min Choi ◽  
Jong Mee Kim ◽  
Gyoung Hoon Lee ◽  
Jin Ju Kim ◽  
...  
Keyword(s):  
Peroxisome Proliferator ◽  
Advanced Stage ◽  
Pro12ala Polymorphism ◽  
Peroxisome Proliferator Activated Receptor

scholarly journals Polymorphism and Human Health

PPAR Research ◽  
2009 ◽  
Vol 2009 ◽  
pp. 1-15 ◽  
Author(s):  
Weimin He
Keyword(s):  
Fatty Acids ◽  
Insulin Sensitivity ◽  
Unsaturated Fatty Acids ◽  
Polycystic Ovary ◽  
Human Subjects ◽  
Saturated Fatty Acids ◽  
Nuclear Hormone Receptor ◽  
Peroxisome Proliferator ◽  
Pro12ala Polymorphism ◽  
Peroxisome Proliferator Activated Receptor

The nuclear hormone receptor peroxisome proliferator activated receptor gamma (PPAR) is an important transcription factor regulating adipocyte differentiation, lipid and glucose homeostasis, and insulin sensitivity. Numerous genetic mutations of PPAR have been identified and these mutations positively or negatively regulate insulin sensitivity. Among these, a relatively common polymorphism of PPAR, Pro12Ala of PPAR2, the isoform expressed only in adipose tissue has been shown to be associated with lower body mass index, enhanced insulin sensitivity, and resistance to the risk of type 2 diabetes in human subjects carrying this mutation. Subsequent studies in different ethnic populations, however, have revealed conflicting results, suggesting a complex interaction between the PPAR2 Pro12Ala polymorphism and environmental factors such as the ratio of dietary unsaturated fatty acids to saturated fatty acids and/or between the PPAR2 Pro12Ala polymorphism and genetic factors such as polymorphic mutations in other genes. In addition, this polymorphic mutation in PPAR2 is associated with other aspects of human diseases, including cancers, polycystic ovary syndrome, Alzheimer disease and aging. This review will highlight findings from recent studies.

scholarly journals The Ala/Ala genotype of PPARY Pro12 Ala polymorphism is associated with late onset of multiple sclerosis

2013 ◽  
Vol 65 (2) ◽  
pp. 447-453
Author(s):  
N. Lukic ◽  
A. Stankovic ◽  
E. Dincic ◽  
M. Bundalo ◽  
Z. Krsmanovic ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Late Onset ◽  
Age At Onset ◽  
Peroxisome Proliferator ◽  
Pro12ala Polymorphism ◽  
Peroxisome Proliferator Activated Receptor ◽  
Post Hoc ◽  
Genotype And Allele Frequencies

The function of peroxisome proliferator-activated receptor ? (PPAR?) in immune regulation, as well as in antiinflammatory and anti-proliferative actions towards T lymphocytes, has been reported. A potential role of PPARs in multiple sclerosis (MS) was suggested. The aim of this study was to investigate if there is an association of PPAR?-2 Pro12Ala polymorphism with MS in 361 patients from Serbia. The genotype and allele frequencies of Pro12Ala polymorphism were not significantly different between controls and patients, or between females and males. In contrast to controls, we detected a rare Ala/Ala genotype in patients with MS. We found that there is a significant association of Ala/Ala genotype with older age at onset (ANOVA, p=0.07; LSD post-hoc, Ala/Ala vs. Pro/Ala, p=0.03, Ala/Ala vs. Pro/Pro p=0.02). It would be useful to validate our results in other populations, as well as to perform follow-up of the disease progression in regard to PPAR? genotypes.

381: The PRO12ALA Polymorphism of Peroxisome Proliferator-Activated Receptor-Gamma Gene and Risk of Colorectal Cancer in a Korean Population

2005 ◽  
Vol 161 (Supplement_1) ◽  
pp. S96-S96
Author(s):  
D H Kim ◽  
Y O Ahn ◽  
B H Lee ◽  
D Y Whang ◽  
S H Kang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Korean Population ◽  
Peroxisome Proliferator ◽  
Pro12ala Polymorphism ◽  
Peroxisome Proliferator Activated Receptor

scholarly journals Pro12Ala Polymorphism in the Peroxisome Proliferator-Activated Receptor- 2 Gene Is Associated With Increased Antilipolytic Insulin Sensitivity

Diabetes ◽  
2001 ◽  
Vol 50 (4) ◽  
pp. 876-881 ◽  
Author(s):  
M. Stumvoll ◽  
H. G. Wahl ◽  
K. Loblein ◽  
R. Becker ◽  
F. Machicao ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
Peroxisome Proliferator ◽  
Pro12ala Polymorphism ◽  
Peroxisome Proliferator Activated Receptor
Sign in / Sign up

Export Citation Format

Share Document